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임윤규(Y.K. Lim),K. Okazaki,S. Matsuki,K. Ogasawara,H. Kida,이영순(Y.S. Lee) 한국예방수의학회 1998 예방수의학회지 Vol.22 No.3
Synthetic petide vaccines prepared according to the cassette theory (Naruse et al., 1994), formalin-inactivated virus and ether-split vaccine of influenza virus A/Aichi/68 (H3N2) were administered intranasally to the pigs. The peptide vaccines contained single or double sets of the peptide sequence of hemagglutinin 127~133 of influenza virus A/Aichi/2/68(H3N2) inserted into the H-2 class allele specific amino acid motif of the agretope composed of residues 43-58 of pigeon cytochrome c in the mouse bearing Ak or Ab. After 4 times immunization, pigs were challenged with 10⁴⁻⁵ PFU of virus intranasally. Intranasal immunization of the pigs with inactivated virus vaccine and split virus vaccine induced antibody production against A/Aichi/2/68(H3N2) virus, protecting them from infection. Synthetic peptide vaccine which contains 2 sets of epitope amino acid sequence evoked protective immune response although antibody response was not detected in the pigs. The present results indicated that intranasal route can be applied for inducing not only mucosal immunity but also systemic immunity against influenza virus infection. Based on the present finding we assume that synthetic peptide vaccine prepared according to Cassette theory may be applicable to the heterogenous species including human.
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