Effect of Menaquinone-4 on Receptor Activator of Nuclear Factor κB Ligand-Induced Osteoclast Differentiation and Ovariectomy-Induced Bone Loss

이애신,성미정,손석준,한아람,홍선미,이상희 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2

Osteoporosis is a progressive metabolic disease characterized by decreased bone mineral density and increased fracture risk. Previous studies have shown that higher intake of vitamin K (VK) correlates with a reduced risk of osteoporosis. However, the effect of menaquinone-4 (MK-4), a specific form of VK, still remains obscure. Therefore, in this study, we investigated the effects of MK-4 on osteoclast differentiation by differentiating RAW 264.7 cells into osteoclasts with the help of receptor activator of nuclear factor-kappa B ligand (RANKL), assessed the mRNA expression of osteoclast-specific genes, and studied the effects of MK-4 in vivo in ovariectomized mice, a postmenopausal osteoporosis murine model. MK-4 inhibited osteoclast differentiation, decreased the mRNA expression of nuclear factor of activated T cells c1 (NFATc1), osteoclast-associated receptor (OSCAR), and cathepsin K (CTSK), and inhibited bone loss in ovariectomized mice. The findings strongly suggest that MK-4 is a therapeutic alternative for postmenopausal osteoporosis.

이달에 생각해 본다 : 양극화 현상 ( Polarization ) 과 말없는 다수 ( Silent Majority )

이애신 기독교한국문제연구회 1989 교회와 한국문제 Vol.2 No.-

Chrysanthemum coronarium L. Extract Attenuates Homocysteine-Induced Vascular Inflammation in Vascular Smooth Muscle Cells

이애신,김이슬,허행전,이상희,성미정 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12

Hyperhomocysteinemia is a main risk factor for phenotypic modulation of vascular smooth muscle cells(VSMCs) and atherosclerosis. Phenotypic switching and proliferation of VSMCs are related to the progression of vascularinflammation. Chrysanthemum coronarium L. is a leafy vegetable with various biological functions, such as antioxidative,anti-inflammatory, and antiproliferative effects. In this study, we aimed to identify the mechanisms underlying the therapeuticand preventive effects of C. coronarium L. extract (CC) in regulating homocysteine (Hcy)-induced vascular inflammation inhuman aortic VSMCs. CC did not exhibit cytotoxicity and inhibited Hcy-stimulated VSMC proliferation and migration. Inaddition, CC promoted Hcy-induced expression of VSMC contractile phenotype proteins, including alpha-smooth muscleactin, calponin, and smooth muscle 22a. CC also decreased Hcy-induced accumulation of reactive oxygen species andexpression of inflammatory markers nicotinamide adenine dinucleotide phosphate oxidase-4 and soluble epoxide hydrolase. These results showed that CC attenuates Hcy-induced inflammatory responses, highlighting its potential as a therapeutic orpreventive target for Hcy-induced vascular inflammation.

식재료 관리

이애랑 대한영양사회 1994 國民營養 Vol.156 No.-

연구논문 : 서울지역 학교급식 시설 현황 및 HACCP 시스템 운영에 따른 장애요인 인지도 조사

이애랑 ( Ae Rang Lee ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.3

The subject study was targeted towards nutrition teacher (dietitian) of elementary, middle, and high schools in Seoul areal. In addition, this study was to investigate the current status of school foodservice securement facilities & equipments and to analyze the obstructive factors for executing the HACCP system. The aim of this study was to provide base-line data so that a more efficient & effective sanitary management system for school foodservise can be settled in. All surveys were distributed and collected via email. A total of 305 survey papers were collected and out of these, 300 school results were analyzed and the results are as follows. The order of the securement facilities & equipment furnished were pre-handing equipments>washing>cooking>inspection>facilities>storage>space area>distribution equipments. The awareness of obstructive factors in executing the HACCP system was a total of 3.17 points and the order was as follows. The general obstructive factors>obstructive factors in the cooking staff executing the HACCP system>collaboration between the school/team leaders and the budget supporting department>obstructive factors in the nutrition teacher (dietitian) executing the HACCP system. School foodservice securement facilities & equipments in Seoul area must be renovated and modernized so as to improve its current situation. Furthermore, leadership programs are necessary to enhance nutritionists` understanding of the HACCP system and the cooking staff`s competencies in instructing and supervising.

식단관리

이애랑 대한영양사회 1994 國民營養 Vol.155 No.-

학교급식 영양(교)사의 변혁적 리더십이 조리종사원의 직무만족과 조직몰입에 미치는 영향

이애랑 ( Ae Rang Lee ) 한국식품영양학회 2011 韓國食品營養學會誌 Vol.24 No.4

The purpose of the study was to identify the relationship transformational leadership, job satisfaction, and organizational commitment of nutrition teacher(dietitian) in school foodservice organization. A total of 209 employees in school foodservice operation were surveyed using a self-administrated questionnaire. The data were analyzed using SPSS Windows(Ver. 18.0) for descriptive analysis and reliability analysis, correlation analysis, and regression. the respondents were 89.0% female, 90.4% under high school, and 90.4% under contract employment. The transformational leadership factors - Charisma (p<0.001), intellectual stimulation, and individual consideration - had positive effects on job satisfaction and organizational commitment. In conclusion, transformational leadership(Charisma) of dietitian directly contributed to job satisfaction and organizational commitment in school foodservice employees.

야콘 뿌리추출액 코팅 쌀 제조 및 항산화력과 관능적 품질 연구

이애랑 ( Ae Rang Lee ) 한국식품영양학회 2010 韓國食品營養學會誌 Vol.23 No.4

The objective of this study was to develop functional rice coated with yacon roots extracts and to evaluate the antioxidant properties and physiological activity of rice coated with yacon extract. The washed rice was coated by spraying yacon extract at 10, 20, 30, and 40 °Brix and dried at room temperature. The moisture contents, color changes, antioxidant properties as total polyphenolics and DPPH radical scavenging activity and instrumental texture property and sensory evaluation change in the yacon root extracts coated rice and uncoated cooked rice were observed during 3 days of storage. Increasing the coating concentration was associated with lower color values(L value) and moisture contents. Total phenolics and DPPH radical scavenging properties generally increased in the cooked rice coated with yacon root extract more than the control (non-coated rice). However, D-20(20 °Brix of the yacon root concentration) resulted in better textural properties and sensory overall acceptability in cooked rice on 0 and 3 storage days. It was concluded that the optimum coating ration of rice and added functional yacon rice were 20 °Brix and 7% respectively, in proportion to the total weight of raw rice.

학교 아침급식 참여 희망 여부에 따른 여중생의 아침식사 관련 실태조사

이애랑,Lee, Ae-Rang 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.6

The purposes of this study were to investigate the eating of breakfast by female middle school students in Seoul, the perception of the school breakfast program (SBP), and determine the factors affecting the intention to participate in SBP. Out of 340 questionnaires distributed to the female middle school students, 334 were returned (98.2% response rate) and 323 were analyzed. The subjects were categorized into two groups by the intention to participate in SBP. Subjects were classified as participating and non participating groups. As a result of analyzing the breakfast intake frequency, 'hardly eat' showed the highest with 18.5% in the participating group and 10.3% in non participating group, while 'eat every day' showed 38.2% in the participating group, and the highest with 65.5% in non participating group (p<0.001). For the reason for skipping breakfast, 'no time' showed the highest with 30.0% in the participating group, 'over sleep' and 'no appetite' showed the highest with 24.8% in non participating group. For the reason for not participating in SBP, 'breakfast should be eaten at home' showed the highest with 47.2% in non participating group and 'may get up early in the morning' showed the highest with 46.2% in participating group (p<0.01). To determine the factors affecting the intention to participate in SBP, logistic regression analyses were conducted for female middle school students. According to the logistic regression analysis, father's education level was independently associated with the intention to participate in SBP in female middle school students [Odds Ratios (OR) 2.38, 95% Confidence Interval (CI) 1.03~5.52]. Frequency of eating breakfast on weekdays (OR 1.36, 95% CI 1.01~1.81), Level of need for school breakfast (OR 0.52, 95% CI 0.35~0.76) and whether to approve school breakfast (OR 0.27, 95% CI 0.18~0.41) were independently associated with the intention to participate in SBP in female middle school students. In conclusion, proper educational efforts for importance of school breakfast could be useful plan to develop school breakfast program.

서울시 일부 비만아동의 영양교육 후 영양지식 변화에 따른 식습관, 식행동 및 체형인식도 차이에 관한 연구

이애랑,문현경,김은경 대한영양사협회 2000 대한영양사협회 학술지 Vol.6 No.2

The purpose of this study was to obtain basic data of nutrition education for obese children in Seoul and to examine dietary habits, dietary behaviors, and body image recognition before and after nutrition education. A convenience sample of 69(male: 54, female: 15) obese children was selected from "98 Children Nutrition Camp" in Seoul. The survey design employed a structured questionnaires. The results of this study were summarized as follows; 1. Anthropometric parameters such as height, weight were measured in 69 obese subjects of age 10-12. 2. Effects of nutrition knowledge were gained by dietary habits, dietary behaviors and body image recognition. 3. Comparison of nutrition knowledge scores for obese children was to obtain basic data of effects for nutrition education.