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Liquid Suspension 법에 의해 제조한 Stearyl Alcohol 구형 Matrix 에 관한 연구
차봉진 ( Bong Jin Cha ),이민화 ( Min Hwa Lee ) 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
Spherical matrixes were prepared from liquid suspension. The drug (sulfamethoxazole) particles dispers ed in distilled water were agglomerated with a melt of matrix material (stearyl alcohol), so dense and free-flowing agglomerates were obtained. The factors affecting the average size, drug content and the release behavior of the resultant products were investigated. The geometric mean diameters and drug contents were affected primarily by the species of matrix, the amountof matrix, and drug particle-size used. In-vitro dissolution studies indicated that the drug was released as a first-order kinetic model. Ths release behaviors varied with the species of matrix, the amount of matrix, size fraction, and drug particle-size used. Steary alcohol proved to play the weak role of matrix in basic medium.
신규 Capsaicin 유도체 DA-5018을 함유한 외용진통제의 제제설계 I : 평가법 확립 및 외용크림제의 설계
차봉진,이응두,김원배,이민화,Cha, Bong-Jin,Lee, Eung-Doo,Kim, Won-Bae,Lee, Min-Hwa 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
To formulate the topical analgesic preparation of a new capsaicin derivative, DA-5018, a skin penetration evaluation system was established and the effect of composition of formulation on skin penetration using this system was evaluated, The effect of massage on hairless mouse skin penetration and inter-day variation of this effect were investigated using test formulations(cream). In massage group, compared with non-massage group, absolute penetration amount of DA-5018 increased and this experimental system was found to be reproducible, The effects of pH of water phase, ratio of oil/water and the concentration of active ingredient in cream on skin penetration were investigated. The permeation of DA-5018 from the cream increased with increasing pH of water phase to 9. But at pH 10, the permeation of DA-5018 decreased, because of the physical instability of the cream. The permeation of DA-5018 from the cream increased with increasing the ratio of oil/water of the cream. The increase of the content of DA-5018 to 0.3% increased the permeation of DA-5018, but at high concentration(1.0%), the permeation of DA5018 decreased, due to the instability of the cream.
신규 Capsaicin 유도체 DA - 5018 을 함유한 외용진통제의 제제설계 Ⅰ: 평가법 확립 및 외용크림제의 설계
차봉진,이응두,김원배,이민화 ( Bong Jin Cha,Eung Doo Lee,Won Bae Kim,Min Hwa Lee ) 한국약제학회 1997 Journal of Pharmaceutical Investigation Vol.27 No.1
N/A To formulate the topical analgesic preparation of a new capsaicin derivative. DA-5018, a skin penetration evaluation system was established and the effect of composition of formulation on skin penetration using this system was evaluated. The effect of massage on hairless mouse skin penetration and inter-day variation of this effect were investigated using test formulations (cream). In massage group, compared with non-massage group, absolute penetration amount of DA-5018 increased and this experimental system was found to be reproducible. The effects of pH of water phase, ratio of oil/water and the concentration of active ingredient in cream on skin penetration were investigated. The permeation of DA-5018 from the cream increased with increasing pH of water phase to 9. But at pH 10, the permeation of DA-5018 decreased, because of the physical instability of the cream. The permeation of DA-5018 from the cream increased with increasing the ratio of oil/water of the cream. The increase of the content of DA-5018 to 0.3% increased the permeation of DA-5018. but at high concentration(1.0%), the permeation of DA-5018 decreased, due to the instability of the cream.