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소아 기관지 천식 환아에서 발열과 기도 감염이 Theophylline 대사에 미치는 영향에 대한 연구
이영진(Young Jin Lee),오지섭(Ji Sub Oh),윤운기(Woon Ki Youn),전성실(Sung Sil Chun),조혜영(Hae Young Cho),차혜리 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1996 소아알레르기 및 호흡기학회지 Vol.6 No.1
N/A Theophylline is widely used in pediatric patients for the treatment of asthma. To achieve adequate bronchodilation and avoid side effect, it is generally accepted that the serum theophylline concentration should be maintained between 10 and 20 ㎍/ml. Clinical effectiveness and toxicity are clearly related to some factors which might alter theophylline pharmacokinetics. Fever or respiratory infection, although it seems to be elevated serum level of theophylline, conflicting reports still appear in journals. Thus we studies retrospectively theophylline clearance, serum drug concentration(SDC), half life, volume distribution in 132 asthmatic children who were admitted to our hospital and received intravenous aminophylline and oral theophylline and tried to reveal the effect of fever or respiratory infection. The results are as follows; 1) In febrile children between 6month and 1 year old, there was no difference in theophylline serum concentration, half life, volume distribution, clearance, 2) In febrile respiratory infection children between 6month and 1 year old, there was no difference in theophylline serum concentration, half life, volume distrbution, clearance. 3) In febrile children, febrile respiratory children over 1 year old, theophylline serum concentration was significantly increased, volume distribution were significantly lower than without febrile, febrile respiratory infection. But, there was no difference in theophylline half life and clearance. As a result, it is suggested that fever, may decrease theophylline volume distribution and increase theophylline serum concentration.