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- 저자 : 윤석(Seok Yun) (검색결과 2 건)
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김덕호,윤석,강현재,김병규,Kim, Deok-Ho,Yun, Seok,Kang, Hyun-Jae,Kim, Byung-Kyu 대한기계학회 2003 大韓機械學會論文集A Vol.27 No.12
In biological cell manipulation, manual thrust or penetration of an injection pipette into an embryo cell is currently performed by a skilled operator, relying on visual feedback information only. Accurately measuring cellular forces is a requirement for minimally invasive cell injections. Moreover, the cellular force sensing is essential in investigating the biophysical properties for cell injury and membrane modeling studies. This paper presents cellular force measurements for the force feedback-based biomanipulation. Cellular force measurement system using piezoelectric polymer sensor is implemented to measure the penetration force of a zebrafish egg cell. First, measurement system setup and calibration are described. Second, the force feedback-based biomanipulation is experimentally carried out. Experimental results show that it successfully supplies real-time cellular force feedback to the operator at tens of uN and thus plays a main role in improving the reliability of biological cell injection tasks.
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DACS (Dielectrophoretically Activated Cell Sorting) using 3D-Asymmetric Microelectrodes
김병규(Byungkyu Kim),박정렬(Jungyul Park),윤석(Seok Yun),이교일(Kyo Il Lee) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
In this paper, a novel 3D-asymmeric microelectrode system has been designed and fabricated to enhance the sorting sensitivity about cells for high-throughput. Basic concept of the presented system, which utilizes relative strength between the negative dielectrophoretic force and the drag force, is the same with conventional 3D microelectrode system. However, varied dielectrophoretic force along the transverse direction of microchannel is realized by presented microelectrode system with changing width in half sphere shaped channel. This varied force increases the sorting sensitivity about cells by inducing the different forces to different kinds of cells distinctly. Based on numerical analysis for the 3D-asymmetric microelectrode, significantly improved sensitivity about cells was verified, and the feasibility of this device was shown by experimental study.
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