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- 저자 : 신응진(Eungjin Shin) (검색결과 1 건)
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최재희(Jaehee Choi),안태성(Taesung Ahn),정동준(Dongjun Jeong),김형주(Hyungju Kim),박소영(Soyoung Park),신응진(Eungjin Shin),정지원(Ji Won Chung),이문수(Moon Soo Lee),백무준(Moo-Jun Baek) 대한종양외과학회 2014 Korean Journal of Clinical Oncology Vol.10 No.2
Purpose: Securin is a regulatory protein, which plays a central role in chromosome stability and control of the metaphase-anaphase transition and anaphase onset. Securin blocks separase/extra spindle pole bodies homolog 1 function, preventing the proteolysis of the subsequent dissociation of the chromosome. Securin is expressed at low level in most tissues, but many patient suffering epithelial neoplasms are overexpressed. The aim our study was to evaluate whether securin affects tumorigenesis and prognosis in patients of colorectal cancer. Methods: To clarify the roles of securin in colorectal tumorigenesis, its expression was examined by immunohistochemistry on a tissue microarray with its comparison with clinicopathologic parameters and prognosis survivals of the colorectal carcinomas. Results: Securin was overexpressedin 272 (76.2%) of 357 colorectal carcinomas. Overexpression of securin was correlated with gender (P=0.060), pathologic T stage (P=0.006) and tumor node metastasis stage (P=0.002), but securin overexpression was not correlated with lymphovascular invasions. Securin overexpression was not correlated with 5-year survival rate by Kaplan-Miere survival model. Conclusion: Securin expression was correlated with T stage and TNM (tumor node and metastasis) stage in colorectal cancer. Our study showed a possible role for securin in colorectal tumorigenesis. These findings indicate that securin has a function of tumorigenesis with tumor enlargement, not of lymphovasculogenesis.
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