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알츠하이머 형질전환 마우스의 출생 후 뇌에서 유전자 발현
지승완(Seung Wan Jee),송연숙(Youn Suk Song),오재호(Jae Ho Oh),김용규(Yong Kyu Kim),심선보(Sun Bo Shim),황대연(Dae Youn Hwang),이수해(Su Hae Lee),서수진(Su Jin Seo),조준용(Jun Yong Cho),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.3
DNA microarrays are a well-established technology for measuring gene expression levels. The aim in the study was to gain insight into potential over-expressed effect of amyloid precursor protein sw (APPsw) on modulation of genes for Alzheimer's Disease (AD). APPsw-transgenic mice, which has been produced by us previously, provide an important resource for identifying differentially expressed genes, since this transgenic line was shown cognitive deficits along with Aβ-42 depositions at 12 months of age. Using cDNA microarray, we compared mRNA levels in 7.4K cDNA clones from postnatal brain of age-matched wild-type mice and Alzheimer's diseased transgenic mice. A total of 44 differentially expressed genes with a 15 up-regulated and with a 29 down-regulated were found in brains from moderatively transgenic mice compared to non-transgenic littermates. Thus, the results allow to the future studies in the functions of each gene, which may be targeted for developing drugs.