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소아기류마티스관절염에서 항Cyclic Citrullinated Peptide항체의 임상적 유용성
강민 ( Min Kang ),손태영 ( Tae Young Sohn ),김성혜 ( Sung Hye Kim ),이혜란 ( Hae Ran Lee ),강희정 ( Hee Jung Kang ),김광남 ( Kwang Nam Kim ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.5
Objective. The aim of this study was to determine the clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile rheumatoid arthritis (JRA). Methods. Sera for anti-CCP assay were obtained from 142 patients with arthralgia in our hospital during the period between November 2010 and October 2011. On the basis of medical records, 83 patients with JRA were designated to the study group, and 59 patients with arthralgia but were treated as transient arthritis to the control group. The values of anti-CCP were then analyzed retrospectively. We used the enzyme linked immunosorbent assay (ELISA) for detecting anti-CCP. Results. Positive anti-CCP values were found in the sera of 11 patients with JRA (13.3%), one patient presented with pauciarticular JRA and the others with polyarticular JRA. There was a statistically significant difference in the anti-CCP values between the JRA group and the control group. However, patients with systemic JRA and arthralgia without JRA had noanti-CCP. Especially, 10 out of 14 (71.4%) patients with RF-positive polyarticular JRA had anti-CCP. In addition, the rate of positive anti-CCP was significantly higher in patients with polyarticular JRA than in the control group. Conclusion. We expect that the presence of anti-CCP may help to evaluate the severity of diseases in patients with JRA. Anti-CCP can be an important biomarker for making early intensive therapeutic decision in patients with polyarticular JRA, which might have more severe course and longer disease duration.
한국 소아기 류마티스관절염 환자에서 Human Leukocyte Antigen-DRB1 대립유전자와의 연관성
이찬재 ( Chan Jae Lee ),손태영 ( Tae Young Sohn ),이대형 ( Dae Hyoung Lee ),이혜란 ( Hae Ran Lee ),김미영 ( Mi Young Kim ),김광남 ( Kwang Nam Kim ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.4
Objective. The aim of this study is to investigate the association of different subgroups of juvenile rheumatoid arthritis (JRA) with human leukocyte antigen (HLA) class II DR alleles. Methods. One hundred and nineteen Korean juvenile rheumatoid arthritis patients were classified as HLA-DRB1 allele. To assess the frequency, phenotype frequencies of all JRA cases and each subtypes were compared to those of 485 adult controls. Results. HLA-DRB1*01 was associated with increased risk of JRA. Furthermore, DRB1*01 was associated with polyarticular JRA and pauciarticular JRA. The frequencies of DRB1*14 and DRB1*15 were higher in systemic JRA patients than the controls. Conclusion. The data of this study on Korean children with JRA suggests that HLA-DRB1*01 was associated with the susceptibility of JRA. The study should be extended to include larger numbers of patients.