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유원상(Won Sang Yoo),우상준(Sang Joon Woo),성영주(Yong Joo Seong),김준희(Joon Hee Kim),최석구(Suck Koo Choi),전영빈(Young Bin Jeon) 대한내과학회 1991 대한내과학회지 Vol.41 No.2
Thirty four patients with essential hypertension, who could successfully discontinued antihypertensive drug treatment, were analyzed to find out the clinical indices which can be used for the prediction of success and duration of the drug withdrawal. The resnets were as follows: 1) The shorter the time for the normalization of blood pressure after drug administration, the longer the duration of drug withdrawal and the lower the rate of remedication. 2) The duration of withdrawal was inversely proportional to the level of pretreatment mean arterial pressure, the duration from the beginning of drug administration to the withdrawal, and the duration from the time when the blood pressure was normalized to the time when the antihypertensive medicines were withdrawn. 3) There was no correlation between the existence of cardiac complications of hypertension and the duration of successful withdrawal. 4) The rate of remedication of antihypertensive medicines among the patients who had stopped taking the medicines was 53%. In conclusion, among the hypertensive patients, if a persons blood pressure could be normalized within 3 months after the beginning of medication, he would be a good candidate for drug withdrawal. In other cases, if the dosages of antihypertensive medicines could be tapered off at the sixth month and taking the medicines could be stopped at the 12-18th month, the duration of drug withdrawal could be 9-18 months.