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- 저자 : 설창안 ( Chang-ahn Seol ) (검색결과 2 건)
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가속도 부하 환경과 저압 저산소 환경의 쥐의 간에 대한 효과
설창안 ( Seol Chang Ahn ),정수영 ( Chung Soo Young ),설진곤 ( Seol Jin Gon ) 국군의무사령부 2010 대한군진의학학술지 Vol.41 No.1
Objectives: Extreme environments, such as hypergravity and hypobaric hypoxia may alter the homeostasis of the liver. We tried to find out if there are some kinds of injuries in the rat liver after the exposure to the chronic intermittent hypobaric hypoxia and/or hypergravity. Methods : We used male Sprague-Dawley rats, which were divided into 4 groups of C, G, H and G+H. Group C was the control group, and group G was exposed only to the hypergravity of 10 G for 10 minutes daily. Group H was exposed only to the hypobaric hypoxia of altitude of 25,000 feet for 1 hour daily. Group G+H was first exposed to the hypergravity and was next exposed to the hypobaric hypoxia daily. The exposure to the extreme conditions was continued for 15 days. After the exposure we checked liver function tests and did the pathologic analysis of the liver. Results: Serum AST and ALT levels in group H and G+H were lower than in group C. Serum total protein (TP) and albumin levels in group G and G+H were higher than in group C. In the pathologic analysis of liver, we found centrilobular necrosis in group G, H and G+H and hyperplastic change of bile ducts in group H and G+H. Conclusions: Chronic intermittent hypobaric hypoxia decreased serum AST and ALT levels and chronic intermittent hypergravity increased serum TP and albumin levels in the rat. The sequence of the pathologic significance may be group C << G < H < G+H.
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권민수 ( Min-soo Kwon ),정수영 ( Soo-young Chung ),설창안 ( Chang-ahn Seol ),설진곤 ( Jin-gon Sul ) 국군의무사령부 2011 대한군진의학학술지 Vol.42 No.1
In the present study, we examined the change of pain behaviors induced by formalin injected subcutaneously (s.c.) into the hind paw, or substance P (SP) and glutamate injected intrathecally (i.t.) in the mouse immobilization stress model. The mouse was restrained either once for 1 h or five times for 5 days (once/day). In the formalin test, a single immobilization stress attenuated pain behaviors (licking, biting or scratching) in the second phase, while it had no effect on the pain behaviors revealed during the first phase. In addition, repeated immobilization stress attenuated pain behaviors revealed during the second phase but not in the first phase. A single as well as repeated immobilization stress decreased pain behaviors induced by substance P i.t. injection, but there were no significant changes in the glutamate test. These results suggest that a single and repeated immobilization stress differentially affects such nociceptive processing induced by formalin, SP, glutamate and pro-inflammatory cytokines in different manners.
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