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연구논문 : 안점막자극시험의 대체시험법으로서 bovine corneal opacity assay의 확립
노경진 ( Kyoung Jin Noh ),석승혁 ( Seoung Hyeok Seok ),백민원 ( Min Won Baek ),이영희 ( Young Hui Lee ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),박성훈 ( Sung Hoon Park ),이현경 ( Hyun Kyoung Lee ),김배환 ( Bae Hwan Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
The objective of this study is establishing of an alternative method using bovine cornea to rabbit eye irritation test. The bovine corneal opacity and permeability assay is checking opacity and permeability of bovine cornea after exposure of chemical irritants. In this study, we measured the opacity of the bovine cornea by quantifying the ability of light to pass through it using opacitometer. In addition, we optimized the basal opacity level before treatment of irritants to bovine corneas. With these results, we established the standard operating procedure of bovine corneal opacity assay.
안점막자극시험의 대체시험법으로서 bovine corneal opacity assay의 확립
노경진 ( Kyoung Jin Noh ),석승혁 ( Seoung Hyeok Seok ),백민원 ( Min Won Baek ),이영희 ( Young Hui Lee ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),박성훈 ( Sung Hoon Park ),이현경 ( Hyun Kyoung Lee ),김배환 ( Bae Hwan Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
The objective of this study is establishing of an alternative method using bovine cornea to rabbit eye irritation test. The bovine corneal opacity and permeability assay is checking opacity and permeability of bovine cornea after exposure of chemical irritants. In this study, we measured the opacity of the bovine cornea by quantifying the ability of light to pass through it using opacitometer. In addition, we optimized the basal opacity level before treatment of irritants to bovine corneas. With these results, we established the standard operating procedure of bovine corneal opacity assay.
Bovine Corneal Opacity Assay법을 이용한 안점막 자극 물질의 검증에 관한 연구
이현경 ( Hyun Kyoung Lee ),노경진 ( Kyoung Jin Noh ),석승혁 ( Seoung Hyeok Seok ),백민원 ( Min Won Baek ),이희영 ( Hui Young Lee ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),박성훈 ( Sung Hoon Park ),김배환 ( Bae Hwan Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
Bovine corneal opacity and permeability assay have been proposed as reliable alternatives to the Draize test. In this study, we measured the opacity of the bovine cornea by quantifying the ability of light to pass through it using opacitometer. We obtained the regular value of basal opacity using bovine cornea collected within three hours after killing. For opacity alone, values obtained for 3 chemicals that are already known as irritants showed a correlation of r=0.994 (p=0.001) with Draize score about same materials. Comparing to reference Draize data from ECVAM (European Centre for the Validation of Alternative Methods), a correlation coefficient with our Draize score for the 3 chemicals was 0.982 (p=0.003). Bovine cornea test data of additional 3 chemicals already known as irritants showed a correlation of r=0.968 (p<0.001) with reference Draize data from ECVAM. Then the bovine cornea opacity test and Draize test with 3 cosmetics were performed. In both tests, we obtained similar results that showed all cosmetics were non-irritant. These results indicate that bovine corneal opacity assay has the potentiality to be developed as alternatives to rabbit eye irritation test.
연구논문 : Bovine Corneal Opacity Assay법을 이용한 안점막 자극 물질의 검증에 관한 연구
이현경 ( Hyun Kyoung Lee ),노경진 ( Kyoung Jin Noh ),석승혁 ( Seoung Hyeok Seok ),백민원 ( Min Won Baek ),이희영 ( Hui Young Lee ),김동재 ( Dong Jae Kim ),나이랑 ( Yi Rang Na ),박성훈 ( Sung Hoon Park ),김배환 ( Bae Hwan Kim ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.2
Bovine corneal opacity and permeability assay have been proposed as reliable alternatives to the Draize test. In this study, we measured the opacity of the bovine cornea by quantifying the ability of light to pass through it using opacitometer. We obtained the regular value of basal opacity using bovine cornea collected within three hours after killing. For opacity alone, values obtained for 3 chemicals that are already known as irritants showed a correlation of r=0.994 (p=0.001) with Draize score about same materials. Comparing to reference Draize data from ECVAM (European Centre for the Validation of Alternative Methods), a correlation coefficient with our Draize score for the 3 chemicals was 0.982 (p=0.003). Bovine cornea test data of additional 3 chemicals already known as irritants showed a correlation of r=0.968 (p<0.001) with reference Draize data from ECVAM. Then the bovine cornea opacity test and Draize test with 3 cosmetics were performed. In both tests, we obtained similar results that showed all cosmetics were non-irritant. These results indicate that bovine corneal opacity assay has the potentiality to be developed as alternatives to rabbit eye irritation test.