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서장수(Jang-Soo Suh),홍재희(Jai-Hee Hong),윤성도(Sung-Do Young),노희숙(Hee-Sook Noh),양동철(Dong-Cheol Yang),양일신(Il-Shin Yang),전정현(Jung-Hyun Jun),김재국(Jae-Kook Kim) 대한전기학회 2012 대한전기학회 학술대회 논문집 Vol.2012 No.10
리튬이차전지용 양극소재를 제조하는 다양한 공정들의 단점을 개선시키기 위하여 본 연구에서는 분무 열 합성법을 연구하였다. 분무 열 합성법은 화염내의 화학적 활성이 높은 열에너지를 이용하여 분체를 제조하는 기술이다. 본 기술로서 얻어지는 분체는 표면장력에 의해 구형의 나노입자를 얻을 수 있다. 또한, 기존의 제조공정에 비하여 공정이 간단하고 미립자 조절, 산화와 환원, 표면개짙 등이 동시에 이루어진다는 장점을 가지고 있다. 또한 본 기술은 다른 양극소재와 음극소재, 세라믹 제조에도 폭 넓게 응용될 수 있을 것으로 기대된다.
면역학적 노화 기전에 관한 연구: T 및 B 세포의 변화
김재식,이원길,서장수,송경은,이중원,이난영,Kim, Jay Sik,Lee, Won Kil,Suh, Jang Soo,Song, Kyung Eun,Lee, Joong Won,Lee, Nan Young,Weksler, Marc E. 대한면역학회 2001 Immune Network Vol.1 No.3
Background: An immunological approach for aging mechanism appears to be important. Lymphocyte subsets analysis in peripheral blood is widely performed to assess the immune status and to diagnose and monitor various diseases. Some lymphocyte subsets are known to change with age, but only few data about age-related reference ragnes for these subsets in healthy individuals have been reported. So we attempted to report reference ranges for these subsets in each age group and review changes of the results with age for the secondary studies about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement (VDJ) including recombination activating genes (RAG-1 and RAG-2). Methods: Lymphocyte subset analysis was performed on 302 subjects, 189 males and 113 females with age group of all decades of life. Two color direct immunofluorescene flow cytometry (FCM) was done using $Simultest^{TM}$ IMK-Lymphocyte kit (Becton Dickinson, USA), $FACScan^{TM}$ (Becton Dickinson, USA) and $FACSCalibur^{TM}$ (Becton Dickinson, USA). Lymphocyte subsets analysed were T ($CD3^+$) and B cells ($CD19^+$), helper/inducer T ($CD4^+$) and suppressor/cytotoxic T cells ($CD8^+$), helper/suppressor ($CD4^+/CD8^+$) ratio and natural killer (NK) cells ($CD3^-CD16^+/CD56^+$). The absolute numbers of each subset were calculated from total lymphocyte counts. Data collected was analysed using SAS 6.12. A P-value of < 0.05 was considered significant. Results: We reported the counts and percentages of lymphocyte and these subsets in each age group. There were no statistically significant differences between male and female subjects. The percentage of $CD4^+$ T cells, and the count of NK cells did not show the significant difference among the various age groups. The age-related changes observed in our study were as following: 1) a decrease in the percentages of T cells, B cells and $CD8^+$ T cells ; 2) a decrease in the counts of B cells and $CD8^+$ T cells ; 3) an increase in the percentage and count of NK cells ; and 4) an increase in the $CD4^+/CD8^+$ ratio. Conclusion: The characteristics of aging process appeared to be showing a marked decrease of lympocyte subsets T and B cells as well as T8 ($CD8^+$). The age-related increase of the percentage of cells bearing NK marker can be interpreted as a compensatory consequence to cope with the decrease of T cells related to the thymic involution. These changes with age appeared to be for the secondary study about immune cell function as lymphocyte blast transformation and immunoglobulin gene rearrangement.
김태욱,한재문,김경덕,윤철환,서장수,김영재,Kim Tae Wook,Han Jae Mun,Kim Kyung Doek,Yun Cheol Whan,Suh Jang Soo,Kim Young Jae 한국방사성폐기물학회 2005 방사성폐기물학회지 Vol.3 No.1
From measured results of the neutron fields at some principal places within the containment building in a CE type nuclear power plant in operation, the radiation exposure of a worker to the neutron at there was evaluated and the equivalent dose reflecting new recommendation (ICRP 60) was compared with that doing the old one (ICRP 26). The measured neutron field was also compared with calibration neutron field. From the analysis, the following conclusion was obtained: the average neutron radiation weighting factor according to new recommendation is 2.41 to 2.71 times higher than the old one. The average neutorn radiation weighting factor at the measured place was similar to that at calibration neutron field. The average neutron energy at measured place was between 42 and 158 keV and higher than that of calibration field of 500 keV. So, the measured equivalent dose in nuclear power plant could be overestimated compared to the real equivalent dose.
김정옥(Jung Ok Kim),서장수(Jang Soo Suh),이영섭(Young Sup Lee) 한국유전학회 2001 Genes & Genomics Vol.23 No.1
N/A Two prominent members of the ATP-binding cassette superfamily of transmembrane proteins, multidrug resistance (mdr) P-glycoprotein and multidrug resistance associated protein (mrp), can mediate the cellular extrusion of xenobiotics and anticancer drugs from cells. mdr and mrp gene expression of a human monocytic HL60 cell were investigated by using reverse transcription polymerase chain reaction. mrp gene was constitutively expressed in HL60 cells. However, treatment of HL60 cells with retinoic acid (RA) or phorbol ester (PMA) induced mdr expressing and showed resistance to adriamycin- or vincristine-induced cell death. RT-PCR analyses revealed that mdr expression induced by PMA or RA were suppressed in cells treated with protein kinase C (PKC) or NFκB inhibitor. RA activated extracellular signal-regulated kinase mitogen-activated protein (MAP) kinase and ribosomal S6 kinase, but not p38 and JNK MAP kinase. Gel shift and supershift analyses with nuclear extracts identified the activation of p50 NFκB subunit which was induced by RA. These results suggested that mdr gene expression in HL60 cells was mediated by PKC/NFκB signal pathways.
다약제 내성 유전자를 이용한 항류마티스 약제의 내성 검사 방법 개발
김상경 ( Sang Gyung Kim ),서헌석 ( Hun Suk Suh ),최정윤 ( Jung Yoon Choe ),이종원 ( Jong Won Lee ),서장수 ( Jang Soo Suh ),김신규 ( Think You Kim ) 대한류마티스학회 2003 대한류마티스학회지 Vol.10 No.1
Objective: A number of disease-modifying anti-rheumatic drugs (DMARDs) have been shown to be more effective than placebo in the management of rheumatoid arthritis (RA). However, most course of DMARDs, except methotrexate, are discontinued after 2 or 3 years, because of toxicity, lack of efficacy or escape from control. The multi-drug resistance (MDR) is a phenomenon in which cells develop cross-resistance to many agents such as anthracyclin, vinca alkaloids and colchicine. In our hypothesis, MDR phenomenon could be implicated in acquired resistance to DMARDs in RA. We have established a mdr1 cell line and tested whether DMARDs are substrate for P-glycoprotein (P-gp). Methods: The mdr1-cDNA was cloned into retroviral vector, and the recombinant retroviral vector was transfected into PA317 cells. The target cells, NIH3T3, were infected with recombinant retroviruses. A colony most resistant to vinblastin was selected for the following experiments; expression of mdr1 gene in NIH3T3 cells was confirmed by RT-PCR, and biological function of mdr1 gene product, P-gp, was tested using Rhodamine-123 (Rh123) efflux assay. Resistance of the target cells expression P-gp which can survive against hydroxychloroquine (HCQ) and methotrxate (MTX) were measured by MTT assay. Results: RT-PCR for mdr1 gene showed successful transfer of the gene into the NIH3T3 cells. Rh123 assay revealed expression of P-gp on the selected cells as follows; Rh123 efflux activity of uninfected NIH3T3 cells was 6%, that of PLXSN was 0.2%, and that of selected cells was 44%. The 50% proliferation inhibitory capacity of the selected cells were twice for HCQ but there was no difference of that for MTX. Conclusion: We established a mdr1 cell line and using the cell line, HCQ was a substrate of MDR, but MTX was not related to MDR.
이재천 ( Jae Cheon Lee ),이중원 ( Joong Won Lee ),서장수 ( Suh Jang Soo ) 대한임상검사과학회 1998 대한임상검사과학회지(KJCLS) Vol.30 No.3
For the estimation of erythrocyte sedimentation rateCESR), conventional methods are widely used because they are simple and economical, but have disadvantages of difficulty in standardization and quality control. So we evaluated the clinical usefulness of an automated ESR measurement as comparing with conventional Westergren method We measured ESR with samples from 117 patients and volunteers. The EDTA blood samples were used for Westergren method and automated StaRRsed rrethod. After drawing the blood the tests were corrpleted in two hours. Westergren meethod was performed and a 3O-min and a 6O-min test were performed for the StaRRsed method and the results were compared The ESR results of the test for the Westergren, the StaRRsed-3} min and the StaRRsed-30 min. methods were a>.6±21.5 mm/hr, 12.2±15.2 mm``hr and 13.1±14.4 mm/hr, respectively, The correlation coefficients were 0.970(p<0.001, 0.982(P<0.001 and O.ffi7 (p<0.001) between Westergren and StaRRsed-30 min., Westergren and StaRRsed-60 min., and the StaRRsed-30 min and StaRRsed-60 min, respectively. The ESR results of StaRRsed-30 min. and StaRRsed-60 min showed a good relationship with the Westergren method So, both the StaRRsed-30 min. and -60 min method can be used instead of the Westergren method And to reduce the estimated time, the StaRRsed-3} min. method can be used more effectively.
천연 냉동보존첨가제를 이용한 골수유래 중간엽 줄기세포의 냉동보존
조현정 ( Hyun Jung Cho ),이승희 ( Seung Hee Lee ),서장수 ( Jang Soo Suh ),유지 ( James J Yoo ),손윤희 ( Yun Hee Shon ) 한국조직공학·재생의학회 2013 조직공학과 재생의학 Vol.10 No.2s
Mesencymal stem cells have been used as an “off the shelf” cellular therapeutics due to their immunomodulatory properties. However, cryoprotectants used to store these cells have not been adequately studied, in terms of their safety and efficacy. In this study, we investigated whether use of natural cryoprotectants free of animal products would be effective in the cryopreservation of human bone marrow-derived mesenchymal stem cells (BMSCs). Cryopreservation medium containing disaccharides, antioxidants and caspase inhibitors combined with a reduced concentration of dimethylsulfoxide (DMSO) was used to cryopreserve BMSCs. The cells were tested for viability with cck-8 assay and a growth curve was generated to measure population doubling. In addition, flow cytometry analysis for cell surface antigens, and RT-PCR for mRNA expression of stem cell markers were performed. The solutions containing trehalose and catalase with 5% or 2.5% (v/v) DMSO produced results similar to those for that of the control (10% (v/v) DMSO and 30% FBS), in terms of cell viability, culture growth, expression of cell surface antigens and mRNA expression of stem cell markers in BMSCs cryopreserved for 3 weeks. Thus, these results show that BMSCs can be cryopreserved with a reduced concentration of DMSO with the addition of disaccharides, antioxidants and caspase inhibitors. This study suggests that human BMSCs can be effectively cryopreserved using natural cryoprotectants combined with reduced concentration of DMSO for cell therapy applications.