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치주인대세포에서 Nicotine과 LPS에 의해 유도된 Human beta Defensin-2의 발현에 MAP kinase의 관여
이상임,이화정,배원정,강순일,이소윤,이영만,신경섭,박재국,류원국,채종문,김은철 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.3
Human β- defensin-2 (hBD-2) is an antimicrobial peptide which is produced by epithelial cells after stimulation with microorganisms or inflammatory mediators. However, little is known as to whether the LPS and nicotine induces the expression of hBD-2 in periodontal l igament (PDL) cells. T he p urpose o f this s tudy was t o investigate t he r oles o f MAPKs pathway o f nicotine a nd L PS-induced hBD-2 expression in PDL cells. The maximal expression of hBD-2 was observed in nicotine 5 mM and LPS 1 μg/ml treated PDL cells. Nicotine and LPS induced the phosphorylation of p38, c-Jun N-terminal kinase 1 and 2 (JNK1/2), and extracellular signal-regulated kinases 1 and 2 (ERK1/2) MAPK. ERK1/2 inhibitor SB203580, p38 inhibitor PD98059, and JNK inhibitor SP600125, blocked the effects of nicotine and LPS on hBD-2 upregulation in PDL cells. These results collectively suggest that hBD-2 is up-regulated in nicotine and LPS-treated PDL cells through activation of p38, ERK and JNK MAPKs pathway. Our data regarding the up-regulation of hBD-2 may help us to understand the antimicrobial mechanism in periodontal disease
철 킬레이터에 의한 골모세포 분화유도에서 Heme Oxygenase-1의 관여
함선도,이선경,국윤아,김용일,신경섭,이소윤,배원정,이상임,이영만,강순일,박재국,류원국,채종문,이승훈,김은철 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.2
The present study aimed to verify the effects of DFO on PDL cells, with particular emphasis on focusing on osteoblastic differentiation. Its mechanisms related to heme oxygenase-1 (HO-1) pathway were also analyzed. DFO increased the expression of HO-1 and early osteoblastic differentiation markers, such as alkaline phosphatase (ALP) and bone sialoprotein (BSP). DFO upregulated heme oxygenase-1. Treatment with HO-1 siRNA blocked the DFO-stimulated osteoblastic differentiation and HO-1 expression. The NF-kB inhibitor pyrrolidine dithiocarbamate, phosphatidylinositol 3-kinase inhibitor Wortmannin, and p38 MAPK inhibitor U0126 blocked the effects of DFO on HO-1 expression and osteoblastic differentiation in PDL cells. Collectively, these data suggest that DFO promotes osteoblastic differentiation and induces the expression of defense protein HO-1 probably via PI3K, p38 MAPK, and NF-kB signalling pathways in PDL cells.
치주인대세포에서 Nicotine과 LPS에 의해 유도된 Human beta Defensin-2의 발현에 MAP kinase의 관여
이상임,이화정,배원정,강순일,이소윤,이영만,신경섭,박재국,류원국,채종문,김은철 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.3
Human β- defensin-2 (hBD-2) is an antimicrobial peptide which is produced by epithelial cells after stimulation with microorganisms or inflammatory mediators. However, little is known as to whether the LPS and nicotine induces the expression of hBD-2 in periodontal ligament (PDL) cells. The purpose of this study was to investigate the roles of MAPKs pathway of nicotine and LPS-induced hBD-2 expression in PDL cells. The maximal expression of hBD-2 was observed in nicotine 5 mM and LPS 1 μg/ml treated PDL cells. Nicotine and LPS induced the phosphorylation of p38, c-Jun N-terminal kinase 1 and 2 (JNK1/2), and extracellular signal-regulated kinases 1 and 2 (ERK1/2) MAPK. ERK1/2 inhibitor SB203580, p38 inhibitor PD98059, and JNK inhibitor SP600125, blocked the effects of nicotine and LPS on hBD-2 upregulation in PDL cells. These results collectively suggest that hBD-2 is up-regulated in nicotine and LPS-treated PDL cells through activation of p38, ERK and JNK MAPKs pathway. Our data regarding the up-regulation of hBD-2 may help us to understand the antimicrobial mechanism in periodontal disease.
Expression of Eukaryotic Translation Initiation Factor-5A in Oral Carcinogenesis
이상임,이준,이선경,배원정,김선주,김용일,최인석,이승훈,이상광,이화준,박제상,김은철 대한구강악안면병리학회 2009 대한구강악안면병리학회지 Vol.33 No.3
Eukaryotic translation initiation factor 5A (eIF-5A) is essential for proliferation of eukaryotic cells, andwas identified as diagnotic marker in cervical intraepithelial neoplasia, cervical and endometrial cancer, but relatively little is known about thein vivo and in vitro expression patterns of eIF-5A in oral premalignant and malignant lesions mirror the expression levels observed in vitro with cells derived from normal oral mucosa, immortalized oral keratinocytes (IHOK) and primary and metastatic oral squamous cell carcinoma (OSCC). We used an oral squamous cell carcinoma (OSCC) progression model composed of cell lines and tissue specimens to characterize expression patterns by Western blotting and immunohistochemistry. eIF-5A and PCNA levels are elevated in IHOKand primary and metastatic OSCC cella as compatred to normal human oral keraitinocytes. eIF5A and PCNA expression was limited to basal cells of normal oral mucosa. eIF-5A and PCNA expression is increased in dysplastic epithelium spreading to more superficial layers, and its expression levels correlated significantly with the degree of dysplasia. Well and moderately differentiated OSCC showed strong expression of eIF-5A and PCNA. These results suggest that upregulated expression of eIF-5A seems to be an important epigenetic alteration that accompanies oral carcinogenic progression, and eIF-5A could be used as an biomarker for oral premalignat lesion or squamous cell carcinoma.
소규모 헤어미용업 종사자들의 직무스트레스 및 근골격계질환 증상 조사
박지은 ( Ji Eun Park ),배상임 ( Sang Im Bae ),배진아 ( Jin Ah Bae ),신세림 ( Se Rim Shin ),진소라 ( So Ra Jin ),송영우 ( Young Woong Song ) 대구가톨릭대학교 자연과학연구소 2014 자연과학연구논문집 Vol.12 No.1
This study investigated the job stress levels and symptoms of musculoskeletal disorders of small hair shop workers in Daegu city. Seventy five hair shop workers were interviewd for job stress and musculoskeletal disorders, and work postures of the six work types were evaluated using REBA method. Forty three workers (57.3%) reported the musculoskeletal symptoms (shoulder 29.3%, neck 26.7%, hand/wrist/finger 24%, arm/elbow 22.7%, low back 22.7%, leg/foot 21.3%). Work posture evaluation score was high in the activities of shampoo, magic, and firm. Work stress levels were not high but the job demand of male workers was higher than the average level of Korean workers.
Gender Differences in Aggression-related Responses on EEG and ECG
임승영,Gwonhyu Jin,정진주,염지우,제갈장환,이상임,조정아,이석규,이영미,김대환,배미정,허진화,문제일,이창훈 한국뇌신경과학회 2018 Experimental Neurobiology Vol.27 No.6
Gender differences in aggression viewed from an evolutionary and sociocultural perspective have traditionally explained why men engage in more direct and physical aggression, and women engage in more indirect and relational aggression. However, psychological and behavioral studies offer inconsistent support for this theory due to personal or social factors, and little is known about the gender-based neurobiological mechanisms of aggression. This study investigates gender differences in aggression through an analysis of electroencephalography (EEG) and electrocardiography (ECG) based neurobiological responses to commonly encountered stimuli, as well as psychological approaches in healthy Korean youth. Our results from self-reports indicate that overall aggression indices, including physical and reactive/overt aggression, were stronger in men. This agrees with the results of previous studies. Furthermore, our study reveals prominent gender-related patterns in γ signals from the right ventrolateral frontal cortex and changes in heart rate through stimulation by aggressive videos. In particular, gender differences in EEG and ECG responses were observed in response to different scenes, as simple aversion and situation-dependent aggression, respectively. In addition, we discovered decisive gender-distinct EEG signals during stimulation of the situation-dependent aggression regions within the right ventromedial prefrontal and ventrolateral frontal regions. Our findings provide evidence of a psychological propensity for aggression and neurobiological mechanisms of oscillation underlying gender differences in aggression. Further studies of oscillatory responses to aggression and provocation will expand the objective understanding of the different emotional worlds between men and women.
철 킬레이터에 의한 골모세포 분화유도에서 Heme Oxygenase-1의 관여
함선도,이선경,국윤아,김용일,신경섭,이소윤,배원정,이상임,이영만,강순일,박재국,류원국,채종문,이승훈,김은철 대한구강악안면병리학회 2011 대한구강악안면병리학회지 Vol.35 No.2
The present study aimed to verify the effects of DFO on PDL cells, with particular emphasis on focusing on osteoblastic differentiation. Its mechanisms related to heme oxygenase-1 (HO-1) pathway were also analyzed. DFO increased the expression of HO-1 and early osteoblastic differentiation markers, such as alkaline phosphatase (ALP) and bone sialoprotein (BSP). DFO upregulated heme oxygenase-1. Treatment with HO-1 siRNA blocked the DFO-stimulated osteoblastic differentiation and HO-1 expression. The NF-kB inhibitor pyrrolidine dithiocarbamate, phosphatidylinositol 3-kinase inhibitor Wortmannin, and p38 MAPK inhibitor U0126 blocked the effects of DFO on HO-1 expression and osteoblastic differentiation in PDL cells. Collectively, these data suggest that DFO promotes osteoblastic differentiation and induces the expression of defense protein HO-1 probably via PI3K, p38 MAPK, and NF-kB signalling pathways in PDL cells.