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청신경종양에서 Vascular Endothelial Growth Factor의 발현
박진수(Jin Su Park),박무균(Moo Kyun Park),이종대(Jong Dae Lee),이원상(Won-Sang Lee) 대한두개저학회 2012 대한두개저학회지 Vol.7 No.2
Objectives : VEGF(vascular endothelial growth factor) is a potent key mediator of angiogenesis, which is necessary during tumor growth. The goal of this study was to determine expression of VEGF in acoustic neuromas and to examine a correlation with clinical characteristics. Methods : The VEGF expression was evaluated by immunohistochemical staining with monoclonal anti-VEGF antibody in 25 cases of the acoustic neuromas. Results : All tumors showed expression of VEGF in cytoplasm of schwannoma cell. The staining density revealed an insignificant correlation between VEGF expression and tumor size, symptom duration. Conclusions : This study suggests that VEGF in acoustic tumor has a role of both angiogenesis and mitogenesis in the growth of schwannoma.