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04 포스터 발표 : 농식품 환경분야(PF) ; PF-01 : 마우스모델에서 PKC 독립적 오토파아지와 아팝토시스유도를 통한 대장암세포 손상 조절에 관여하는 푸마니신 B1의 역할
마헨드라 ( Mahendra Pal Singh ),소렌폴 ( Souren Paul ),강선철 ( Sun Chul Kang ) 한국환경농학회 2015 한국환경농학회 학술대회집 Vol.2015 No.-
Induction of pro-death mechanisms during oxidative stress can be divided into two categories, autophagy and apoptosis. FB1 induced toxicity in colon tissues include particular type of cell death via oxidative stress is not clear yet. For this purpose, we employed murine model and intraperitoneally injected with FB1 (2.5mg/kg body weight) to explore the cellular damage response in colon tissue. As a result of consecutive four days treatment of FB1 led to disorganized tissue architecture elucidated by hematoxyline and eosin staining, altered activity of basic metabolic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in blood serum and plasma. Moreover, FB1 treatment activated autophagy and apoptosis related signaling mechanisms characterized by induced expression of associated markers such as PERK, IRE1α, BECN1 and LC3II. In addition, we observed reduced protein kinase c (PKC) activity. All these recorded parameters clearly depict oxidative stress mediated induction of autophagy and apoptosis which led to colon tissue damage in response to FB1 treatment in independent to PKC expression. Therefore, altogether these results indicate the role oxidative stress induced autophagy and apoptosis mechanism in FB1 mediated colon tissue damage.
농식품 환경 분야(PF) : PF-17 ; 마우스 모델을 이용한 아크릴아마이드 유도된 신독성 및 간독성에 대한 morin hydrate의 보호효과
강선철 ( Sun Chul Kang ),리카자카 ( Rekha Jakhar ),마헨드라 ( Mahendra Pal Singh ) 한국환경농학회 2014 한국환경농학회 학술대회집 Vol.2014 No.-
Acrylamide (AA) is considered as a potential carcinogen by Food and Drug Administration (United States). AA is produced during the heating of starchy foods like potato chips, french fries, and coffee at high temperature and is regarded as a potential genotoxic carcinogen. However, a number of researches going on worldwide in the field of toxicology are concerned about the carcinogenicity of AA. Morin hydrate is a potent flavonoid compound. It is a yellow color substance that can be isolated from Maclura pomifera (Osage orange). So, in this study we have used morin hydrate to abolish the AA-induced toxicity by determining the variety of hematological, biochemical and immunological parameters in the serum, urine, liver and kidney of male mice. Subcutaneous injection of morin hydrate at a concentration of 5mg and 15mg kg-1 per day for 5 days along with 10mg kg-1 AA exposure could significantly reduce the toxicity of AA. As we found a significant reduction in the level of thiobarbituric reactive substances (TBARS) in tissue and serum, also, a significant reduction in antioxidant enzymes like superoxide dismutase (SOD), glutathione S transferase (GST), glutathione (GSH), myeloperoxidase (MPO) was observed. On the other hand, level of aspartate amino transferase (AST), alinine aminotransferase (ALT) in serum was found to decrease in a concentration dependent manner of morin hydrate. On the basis of the present study we conclude that morin hydrate can potentially protect renal and hepatic toxicity induced by AA.