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rhBMP-2를 이용한 조직공학;치과 임프란트에서의 골 재건
울프비케쇼,올리버하니쉬,마이클데니쉬마이어,조규성,김종관,Wikesj, Ulf ME.,Hanisch, Oliver,Danesh-Meyer, Michael J.,Cho, Kyoo-Sung,Kim, Chong-Kwan 대한치주과학회 1999 Journal of Periodontal & Implant Science Vol.29 No.3
The preclinical and clinical studies reviewed herein show that rhBMP-2 induces normal physiologic bone in relevant defects in the craniofacial skeleton. The newly formed bone assumes characteristics of the adjacent resident bone, and allows placement and osseointegration of dental implants. Clearly, the bone inducing capacity of rhBMP-2 is carrier and site dependent. rhBMP-2 in an absorbable collagen sponge carrier induces relevant bone formation in space providing defects. Space providing carries extends this possibility to non-space providing sites. Notably, some ceramic and polymeric biomaterials may substantially interfere with rhBMP-2 induced osteogenesis.