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Fenbufen 과 β- Cyclodextrin 과의 inclusion complex
류장하 ( Jang Ha Ryu ),이종욱 ( Jong Wook Lee ),박영주 ( Young Ju Park ),김영일 ( Young Il Kim ) 한국약제학회 1984 Journal of Pharmaceutical Investigation Vol.14 No.1
The interactions of Fenbufen with α-, and β-cyclodextrins in aqueous solution were investigated by solubility method, Ultraviolet absorption and Circular dichroism spectroscopies. And also the inclusion complexes in solid powder form were made by the freeze-drying method in molar ratio 1:1. The inclusion complex formation was confirmed by Infrared, Differential thermal analysis, and X-ray diffraction measurements. The dissolution of solid Fenbufen inclusion complex was examined, and then its analgesic and antiinflammatory effects were determined in comparison with Fenbufen alone. The apparent release of Fenbufen from the inclusion complex obtained by freezedrying method was significantly improved, but no significant difference in its analgesic and antiinflammatory effects was found.
김승인,류장하,차돈규 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.1
Fenbufen은 비스테로이드성 진통, 항염약물로써 경구로 투여되어 통증 및 염증제거에 효과를 나타내며 난용성인 물질이다. Fenbufen의 용해도를 증가시키기 위하여 fenbufen과 lysine을 결합시켜 fenbufen·lysine를 얻고 이를 원소분석, IR, DSC, NHR등으로 확인하였다. Fenbufen·lysine의 pH에 따른 용해도 및 용출율과 acetic acid에 의한 진통작용 및 carrageenin 족척부종법에 의한 항염작용을 검토하였다.
김종갑,류장하 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.4
Acetaminophen, fenbufen, and mefenamic acid tablets were formulated with the same additives, granulated to different sizes, ranging 30∼200mesh, and compressed by pressure of 0.5∼2.0 ton·㎝^(-2). The hardness and disintegration time of the three tablets were determined. The dissolution rates of the three tablets at critical point of pressure were investigated. The results showed that fenbufen, and mefenamic acid tablet had critical compression pressure of 1.0 ton·㎝^(-2), but acetaminophen tablet had that of 1.5 ton·㎝^(-2). Neverthless, three tablets were disintegrated within 5 min. Among the three tablets, mefenamic acid tablet followed zero order of dissolution and the rate constants were as follows; 1.68 ㎎·min^(-1) (30∼50mesh), 1.76㎎·min^(-1) (50∼80 mesh) and 4.85 ㎎·min^(-1) (80∼200mesh).