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성인에 있어서의 혈장제 백신의 면역 지속성과 면역 증강 반응
선희식(H . S . Sun),정규원(K . W . Chung),김부성(B . S . Kim),노재철(J . C . Rho),정환국(W . K . Chung) 대한내과학회 1987 대한내과학회지 Vol.32 No.6
N/A To find out the persistence of the anti-HBs level in adult recipients after primary immunization with a vaccine and secondary boosting responses with another vaccine, we screened subjects who had no HBsAg, anti-HBs and anti-HBc before immunization with radioimmunoassay technique, and submitted them to primary immunization with a plasma-derived vaccine and secondary boosting with another plasma derivative. Finally, we could select 36 subjects who were possible to complete the follow-up study until after secondary boosting. The primary booster injection was performed at 6 months and secondary boosting at the 25th month after initial vaccination. Among 11 recipients, in whom antibody levels were increased by, more than 9,9 R.U. after primary boosting with 3 μg dose of vaccine prepared by A. Co. (V.A.) (well responders), anti-HBs levels decreased in all recipients at the 25th month after first vaccine treatment, and 4 of these showed negative seroconversion. In another 11 recipients, who had no antihody responses after inadequate primary vaccine treatment with V.A. (non-responders), no anti-HBs was found in their blood 25 months after vaccine initiation. At one month after secondary booster injection with 20 pg dose of hepatitis B vaccine provided by B. Co. (V. B.), a marked rise of anti-HBs titer was observed in all 11 well responders, and 6 of the 11 non-responders also responded. Among participants in this study, 14 who responded to primary immunization with V.B. but in whom no primary boosting effect was seen, 3 showed sero-negative conversion 25 months after vaccine initiation. A rise of more than 9.9R.U. of anti-HBs, after the secondary booster injection with V.A., was observed in 6 of the 14 subjects even in sero-negative cases.
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