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RAW264.7 대식세포에서 풀솜대 추출물의 nitric oxide 및 prostaglandin E<sub>2</sub>생성 저해효과
남정환,서종택,김율호,김기덕,유동림,이종남,홍수영,김수정,손황배,김현삼,김보성,이경태,박희준,Nam, Jung-Hwan,Seo, Jong-Taek,Kim, Yul-Ho,Kim, Ki-Deog,Yoo, Dong-Lim,Lee, Jong-Nam,Hong, Su-Young,Kim, Su-Jeong,Sohn, Hwang-Bae,Kim, Hyun-Sam,Kim, B 한국식물생명공학회 2014 식물생명공학회지 Vol.41 No.4
본 연구에서는 풀솜대(Smilacina japonica)의 전초를 이용하여 세포독성 및 항염증 활성 효과를 평가하였다. 대식세포인 RAW264.7 cell에서 염증 매개 물질인 lipopo-lysacchride (LPS)로 염증을 유발시켜 nitric oxide (NO)와 prostaglandin $E_2$ ($PGE_2$) 같은 염증 유발인자들의 억제효과를 확인하였다. 풀솜대 chloroform 분획물의 염증 유발인자 억제 시 $IC_{80}$ value를 측정하였을 때 nitric oxide 및 prostaglandin $E_2$ 생성을 농도의존적으로 현저하게 저해하는 농도는 각각 53.3과 $32.5{\mu}g/ml$이었다. 따라서 본 연구 결과는 풀솜대의 chloroform과 같은 비극성용매 분획물들이 유의성 있는 항염증 효과를 나타내었으며, 이러한 효능은 예방의학적 가능성을 충분히 가지고 있기에 염증성질환의 예방을 위한 건강 기능성식품의 개발 가능성을 제시할 수 있을 것으로 기대된다. 또한 염증과 관련된 사이토카인 및 단백질 발현 메커니즘에 대한 추가적인 연구가 필요할 것으로 판단된다. Smilacina japonica is a localized common rhizomatous flowering plant, This plant is often used in Korean traditional systems of medicine as a remedy for migrain, diplegia, physical impurity, blood circulation, abscess and contusion. Generally drugs that are used for arthritis have antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of S. japonica using the ethanolic extract and its subfractions. To evaluate the anti-inflammatory effects, we examined the inflammatory mediators such as nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) on RAW 264.7 macrophages. Our results indicated that hexane fraction significantly inhibited the LPS induced NO and $PGE_2$ production in the cells. The hexane fractions inhibitory activity for NO tests with $IC_{50}$ values showed in $53.3{\mu}g/ml$ and $PGE_2$ tests with $IC_{50}$ values showed at $32.5{\mu}g/ml$. Theseis result suggest a potential role of hexane fraction from S. japonica as source of anti-inflammatory agent.
개소시랑개비 추출물의 RAW264.7대식세포에서 in vitro 항염효과
남정환,김현삼,김병진,유홍섭,장동칠,진용익,유동림,최종근,박희준,이승빈,이경태,박수진,Nam, Jung-Hwan,Kim, Hyun-Sam,Kim, Byoumg-Jin,Yu, Hong-Seob,Chang, Dong-Chil,Jin, Yong-Ik,Yoo, Dong-Lim,Choi, Jong-Keun,Park, Hee-Jhun,Lee, Seung-Bin,Lee 한국식물생명공학회 2017 식물생명공학회지 Vol.44 No.1
본 연구에서는 개소시랑개비 (Potentilla supina)의 전초를 이용하여 세포독성 및 항염증 활성 효과를 평가하였다. 대식세포인 RAW264.7 cell에서 염증 매개 물질인 lipopo-lysacchride(LPS)로 염증을 유발해 nitric oxide (NO), Inducible nitric oxide synthase (iNOS)와 prostaglandin$E_2$($PGE_2$) 같은 염증 유발 인자들의 억제효과를 확인하였다. 개소시랑개비 ethyl acetate 분획물의 염증 유발 인자 억제 시 $IC_{80}$ value를 측정하였을 때 nitric oxide 및 prostaglandin $E_2$ 생성을 농도의존적으로 현저하게 저해하는 농도는 각각 29.34와 $50.75{\mu}g/ml$이었고 Inducible nitric oxide synthase의 양도 $50{\mu}g/ml$ 처리하였을때 농도 의존적으로 발현 감소 하였다. 따라서 본 연구결과는 개소시랑개비의 ethyl acetate 분획물과 같은 비극성용매 분획물들이 유의성 있는 항염증 효과를 나타내었으며, 이러한 효능은 예방의학적 가능성을 충분히 가지고 있기에 염증성질환의 예방을 위한 건강 기능성식품의 개발 가능성을 제시할 수 있을 것으로 기대된다. 또한 염증과 관련된 사이토카인 및 단백질 발현 메커니즘에 대한 추가적인 연구가 필요할 것으로 판단된다. Potentilla supina (Rosaceae) has traditionally been used to treat disorders of hemostasis, dysentery, malaria, bloody discharge and arthritis, and it has antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of P. supina using the ethanolic extract of P. supina and its sub-fractions. To evaluate the anti-inflammatory effects of P. supina, we examined the inflammatory mediators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS) and prostaglandin $E_2$ ($PGE_2$) in RAW 264.7 cells. Our results indicated that ethyl acetate fraction significantly inhibited LPS-induced NO, iNOS and $PGE_2$ production in RAW 264.7 cells. This result showed that ethyl acetate fraction of P. supina is expected to be a good candidate for development into a source of anti-inflammatory agents.
곧은 나무이끼(Climacium dendroides)의 식물 화학적 성분연구
남정환 ( Jung Hwan Nam ),조인숙 ( In Sook Cho ),김수정 ( Su Jeong Kim ),남춘우 ( Chun Woo Nam ),서종택 ( Jong Taek Seo ),유동림 ( Dong Lim Yoo ),김원배 ( Won Bae Kim ),유승열 ( Seung Yeol Ryu ),이응호 ( Eung Ho Lee ),김민영 ( Min 한국응용생명화학회 2008 Applied Biological Chemistry (Appl Biol Chem) Vol.51 No.2
개쇠랑개비(Potentilla supina)추출물의 항산화 활성 및 Total Polyphenol분석에 관한 연구
남정환 ( Jung-hwan Nam ),김현삼 ( Hyun-sam Kim ),구본철 ( Bon-cheol Koo ),정진철 ( Jin-cheol Jeong ),서종택 ( Jong-taek Seo ),김율호 ( Yul-ho Kim ),김기덕 ( Ki-deog Kim ),이종남 ( Jong-nam Lee ),홍수영 ( Su-young Hong ),김수정 ( S 충북대학교 과학교육연구소 2016 과학교육연구논총 Vol.32 No.1
The objectives of this study were to investigate the antioxidant activity and total poly phenol content from Potentilla supina extract and fraction, DPPH free radical scavenging activity was most excellent in the ethyl acetate fraction (95.4±0.3%) and ethanol extract(62.3±1.9%) of 250ug/m concentration, The ethanol extract (53.1±2.8mg/g), and the ethyl acetate fraction (316.4±11.8mg/g) showed relatively higher total polyphenol contents. There was the large amont of total polyphenol content in the ethanol extract and the ethly acetate fraction, and their free radical scavenging activities were higher effects.
남정환 ( Jung-hwan Nam ),김현삼 ( Hyun-sam Kim ),구본철 ( Bon-cheol Koo ),정진철 ( Jin-cheol Jeong ),서종택 ( Jong-taek Seo ),김율호 ( Yul-ho Kim ),김기덕 ( Ki-deog Kim ),이종남 ( Jong-nam Lee ),홍수영 ( Su-young Hong ),김수정 ( S 충북대학교 과학교육연구소 2016 과학교육연구논총 Vol.32 No.1
Recently, cvs `Hongyoung` with red color in skin and `Jayoung` with purple color in flesh potatoes were developed in Korea. Generally, it has been well known that the color of skin and flesh is due to an accumulation of anthocyanin that exhibit many functional properties for human health. In recent study, we found that extracts of two color-fleshed potatoes showed the antimutagenic effect and cytotoxity to human cancer cell lines, As functional properties of color-fleshed potatoes are widely introduced to consumers, it will be considered that the demand for the processing to various food materials including powder increase. This study was carried out to investigate the effect of steaming and drying conditions on the quality of the powders in color-fleshed potatoes. Cvs. `Hongyoung` and `Jyoung` and `Superior` as control were treated with different steaming times drying, room condition drying and hot air drying were treated. The quality factors such as anthocyanin content, moisture and hardness of powder were investigated. As a result of determining of Hunter`s value, powder color was well maintained after drying process by freeze drying for `Jayoung` and room condition drying for `Hongyoung`. anthocyanin in all cultivars as compared with other methods. The optimum hardness of powder was obtained in the steaming treatment for about 20 minutes before drying for all cultivars. Based on these results, our findings suggest that powders obtained from color-fleshed potatoes are able to be used for functional food materials.
음나무 잎 및 수피의 진통소염효과 및 아주반트로 유발된 산화적 스트레스에 대한 효과
박희준,남정환,정현주,김원배,박광균,정원윤,최종원,Park, Hee-Juhn,Nam, Jung-Hwan,Jung, Hyun-Ju,Kim, Won-Bae,Park, Kwang-Kyun,Chung, Won-Yoon,Choi, Jong-Won 한국생약학회 2005 생약학회지 Vol.36 No.4
The leaves (KPL) of Kalopanax pictus (KP) are used as a vegetable or a functional food in Korean society. The stem bark (Kalopanacis Cortex, KPS) has been traditionally used to treat neurotic pain, rheumatoid arthritis and diabetic disease. This research was undertaken to demonstrate that the leaf extract of KP (KPL) has also the antinociceptive and antiinflammatory effects like the extract (KPS) of Kalopanacis Cortex and to compare the activity levels of several extracts obtained from KP. Antinociceptive and antiinflammatory effects were measured against the extracts described as followings; KPL-1 (the MeOH extract obtained from the leaf shoot of KP collected on May), KPL-2 (the MeOH extract from KP collected on June), KPL-3 (the MeOH ectract from KP with no thorns), KPS-1 (MeOH extract from KPS of a Korean habitat), KPS-2 (MeOH extract from KPS of a Chinese habitat). The antimociceptive test undertaken by acetic acid-induced writhing, hot plate-, and tail-flick methods using mice. The anti-inflammatory test was also undertaken by measuring the edema in the carrageenan-induced test. The order of activity potency in the antinociceptive and antiinflammatory assays was commonly shown as followings: KPL-3>KPS>1>KPS-2>KPL-1>KPL-2. This order was also observed in acetic acid-induced vascular permeability test. The antiinflammatory activity in carrageenan-induced assay was also observed as the following order: KPL-3>KPS- 1>PS-2>KPL-1>KPL-2. In addition, adjuvant-induced rats were used for a model to assess the oxidative stress. Treatment of the rat with the extracts reduced serum thiobarbituric acid-reactive substances (TBARS), hydroxy radical(OH) and superoxide dismutase(SOD) activity caused by FCA together together with the inhibition of hepatic TBARS level and lipofuscin content. The above finding suggests that the leaf extract has the antinociceptive and antinflammatory activity. It is also suggested that KPL-3 with more potent activity than other tested extracts could be developed for a new available biomaterial.