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RISS 인기검색어
- 검색키워드
- 저자 : 나용주 ( Yong Joo Na ) (검색결과 3 건)
- 무료
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Tensile stress regulation of NGF and NT3 in human dermal fibroblast
Mina Kim(김미나),Jung Woo Hong(홍정우),Minsoo Nho(노민수),Yong Joo Na(나용주),Hyunjong Shin(신현정) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.11
Fibroblast is constantly subjected to mechanical loads in connective tissues where mechanical signals are converted to intercellular biochemical events. The aim of this study is to understand the effects of tensile stress on the neurotrophin (NT) and transforming growth factor (TGF) expression of fibroblast in vitro. Nerve growth factor (NGF) stimulates fibroblast migration, and TGF is related to tissue repair. In this study, at the uniaxial stretch of 10% strain and frequency of 0.5 ㎐, different resting times of 0, 20, and 60 min are placed in between 10 min stimulations periods. Results show increase in NGF mRNA levels and a substantial decrease in NT3 mRNA after 1 hr of stimulation, indicating that the tensile stress may regulate NGF and NT3, key factors for the neurocosmetic applications. The mRNA level for TGF-α and TGF-β2 had increased up to two-folds after 1 hr of stimulation, showing that the tensile stress may control TGF, an important part of wound healing.
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Differentiation of fibroblast through NGF by uniaxial tension
Mina Kim(김미나),J.W. Hong(홍정우),Minsoo Nho(노민수),Yong Joo Na(나용주),Jennifer H. Shin(신현정) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
Mechanical tension plays an important role in the homeostasis of connective tissue fibroblast. Differentiation of fibroblast to myofibroblasts is related to late stage of wound healing process, stimulating fibroblast to produce collagen. Previous studies have shown that the external NGF induces a-SMA expression in conjunctival fibroblasts through TGF-β1. Our previous data shows that both NGF and TGF transcription exhibit tensile stress dependent behavior which could lead to enhancement of wound healing. We investigate the effects of uniaxial tensile stress on the expression of a-SMA, distinction between fibroblast and myofibroblast, through increase of NGF. Uniaxial tension lead to a-SMA express on the fibroblast and external NGF and TGF treatment induces stress fiber containing α-SMA. Our results may imply that the induction of a-SMA is a consequence of regulation of NGF and TGF by uniaxial tension in fibroblasts.
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이성훈 ( Sung Hoon Lee ),민대진 ( Dae Jin Min ),나용주 ( Yong Joo Na ),심종원 ( Jongwon Shim ),권이경 ( Lee Kyoung Kwon ),조준철 ( Jun-cheol Cho ),이해광 ( Hae Kwang Lee ) 대한화장품학회 2013 대한화장품학회지 Vol.39 No.1
칼슘, 마그네슘과 같은 양이온은 피부 장벽을 보호하는 기능이 있다고 알려져 있다. 본 연구의 목적은 칼슘, 마그네슘, 망간, 불소로 이루어진 미네랄워터의 피부 장벽 보호 기능을 확인하기 위한 것이다. 피부가 자외선에 노출되게 되면 밀착연접(tight junction, TJ)이 파괴되며, 밀착연접으로 이루어진 피부 장벽도 손상 받게 된다. 미네랄워터가 자외선에 의해 손상된 피부의 장벽기능을 보호할 수 있는지 평가하기 위해 인공피부 모델을 이용한 실험을 진행하였다. 인공피부에 자외선을 조사하고 미네랄워터를 처리하면 피부 장벽 손상을 막아준다. TJ permeability assay를 통하여 자외선 처리 시 손상된 밀착연접 장벽이 미네랄워터 처리에 의해 유지되는 것을 확인하였다. 각질형성세포를 이용한 실험에서 미네랄워터가 밀착연접 구조를 유지시켜 주고, 자외선에 의해 감소된 occludin 단백질의 생성량이 회복되는 것을 확인하였다. 따라서 본 연구를 통해 미네랄워터는 자외선에 의한 피부 장벽 파괴를 막아주는 효과가 있음을 확인할 수 있었다. Bicationic minerals such as calcium and magnesium are known to protect the skin barrier. The principal objective of this study was to evaluate the skin barrier protective effects of mineral water, which is composed of calcium, magnesium, manganese, and fluorine. UVB irradiation induces a destruction of tight junction (TJ) components. The TJ permeability barrier was also disrupted by UVB irradiation. We employed a skin equivalent model to assess the efficacy of mineral water in this regard. Mineral water maintained the structure of the skin equivalents following UVB irradiation. The results of the TJ permeability assay showed that mineral water helped to maintain the TJ permeability barrier after UVB irradiation in skin equivalent model. Mineral water supported the structure of TJ components and restored the occludin protein level in differentiated normal human keratinocytes after UVB irradiation. In conclusion, we found out the protective effect of mineral water against UVB irradiation.
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