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인체 세포생리학-조직의 전기전도-심장역학 기전을 포함하는 3차원 가상심장의 개발
심은보(Eun Bo Shim),권순성(Soon Sung Kwon),김유석(Yoo Seok Kim),김정민(Jung Min Kim),최선철(Seon Cheol Choi),김형종(Hyung Jong Kim),김헌영(Hun Young Kim) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
A 3D virtual heart model is proposed to simulate an integrative analysis of heart physiology. This consists of the models of electrophysiology of human cells, electric wave propagation of tissue, heart solid mechanics, and 3D coronary blood hemodynamics. The 3D geometry of human heart is discretized to a finite element mesh for the simulation of electric wave propagation and mechanics of heart. In cellular level, excitations by action potential are simulated using the existing human models. Then the contraction mechanics of a whole cell is incorporated to the excitation model. The excitation propagation from SA node to ventricular cells are transiently computed in the 3D cardiac tissue using a mono-domain method of electric wave propagation in cardiac tissue. The increase of calcium concentration in cardiac cells induces cellular forces which eventually converted to heart contraction.