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김영권 ; 김태운 ; 유재일 ; 최치원 ; 이점규 ; 김봉수 김천대학교 2004 김천대학교 논문집 Vol.25 No.-
목적 : C. albicans 뿐만 아니라 non-albicans Candida의 감염 증가와 항진균제 내성 칸디다 종 출현이 세계적으로 보고되고 있다. 본 연구에서는 국내 1,2차 의료기관, 종합병원과 보건소에서 분리된 Candida 분리주를 대상으로 분리균의 분포를 조사하고 voriconazole을 포함한 4가지 항진균제에 대한 Candida spp.,의 감수성 분포를 조사하였다. he incidence of Candida albicans infections with non-albicans Candida and antifungal resistant Candida species have been increased worldwide. This study was carried out to determine Candida species dis-tribution and susceptibility to four antifungal agents including voricona zole against Candida isolates collected from hospitals and community health centers. Candida species identification was performed using the Vitek instru-ment or Candida CHROM agar medium. The MICs of antifungal agents for Candida species were determined by the NCCLS broth microdilution method and confirmed with E test method. In non-tertiary hospitals and community health centers, C. albicans was still the most common isolates, but incidence rate of non-albicans Candida isolated from blood specmens in tertiary hospitals was more than that of C. albicans. The fluconazole resistant Candida species were rare but the resistance to amphotericin B and 5 flucytosine was detected in C. albicans of all the institution. Most of Candida species showed low MICS (50%. MIC 0.03 ug/ml) to voriconazole compared to fluconazole.