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컴퓨터 모사기법을 이용한 Michaelis-Menten Kinetic 상수 추정치의 비교 분석
김연웅,강윤세,변시명,Kim, Yeon-Woong,Kang, Yoon-Se,Byun, Si-Myung 생화학분자생물학회 1987 한국생화학회지 Vol.20 No.2
측정 초기 속도의 오차가 등분산 정규분포를 가지는 가정 하에서 Michaelis-Menten 상수 $K_m$와 $V_{max}$를 계산하는데 사용하는 직선 변형식 3가지 (Lineweaver-Burk 방법, Hanes-Woolf 방법, Woolf-Augustinsson-Hofstee 방법)와 Cornish-Bowden의 direct linear 방법, Wilkinson-Cleland 방법들을 컴퓨터 모사 기법을 이용하여 정확도와 정도의 측면에서 서로 비교하였다. 그 결과 Wilkinson-Cleland 방법, Cornish-Bowden의 Direct linear 방법, Hanes-Woolf 방법, Woolf-Augustinsson-Hofstee 방법, Lineweaver-Burk 방법의 순서로 우수함을 알았다. 최소 필요 적정 기질농도 수는 9개에서 12개 사이였다. 적정 기질농도 범위는 6 $K_m$에서 12 $K_m$으로 각 방법에 따라 조금씩 차이가 있었다. The Michaelis-Menten equation was fitted to simulated data containing the homoscadastic error from three linear transformations (Lineweaver-Burk, Hanes-Woolf, Woolf-Augustinsson- Hofstee), Cornish-Bowden's direct linear plot and the method of Wilkinson-Cleland. The best method was those of Wilkinson-Cleland's. The Lineweaver-Burk plot appeared the worst method. The proper ranges of substrate concentration were different from 6 $K_m$ to 12 $K_m$, which were dependent on each method. Substrate concentration between 9 and 12 determinations which were even-spaced were adequate.
컴퓨터 모사기법을 이용한 Michaselis - Menten Kinetic 상수 추정치의 비교 분석
김연웅,강윤세,변시명 ( Yeon Woong Kim,Yoon Se Kang,Si Myung Byun ) 생화학분자생물학회 1987 BMB Reports Vol.20 No.2
The Michaelis-Menten equation was fitted to simulated data containing the homoscadastic error from three linear transformations (Lineweaver-Buck, Hanes-Woolf, Woolf-Augustinsson-Hofstee), Cornish- Bowden`s direct linear plot and the method of Wilkinson-Cleland. The best method was those of Wilkinson-Cleland`s. The Lineweaver-Burk plot appeared the worst method. The proper ranges of substrate concentration were different from 6 K_m to 12 K_m, which were dependent on each method. Substrate concentration between 9 and 12 determinations which were even-spaced were adequate.
김연웅 ( Yeon Woong Kim ),김준군 ( Joon Goon Kim ),김병수 ( Byeong Su Kim ),최진화 ( Jin Hwa Choi ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.10
Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder that is characterized by clonal proliferation of myeloid cells in the bone marrow. PMF should be distinguished from other chronic myeloproliferative neoplasms. Leukemia cutis is defined as cutaneous infiltration of malignant hematopoietic cells. The clinical features of leukemia cutis are variable, and the lesions may be localized or disseminated. A 53-year-old male individual presented with a month`s history of several erythematous papules on the trunk. The number of lesions had increased, but he had no subjective symptom. He was diagnosed with PMF 3 years ago. For the last 5 months, he has suffered from inguinal lymph node enlargement, myalgia, and abdominal discomfort. Laboratory test showed leukocytosis in the peripheral blood (blast cells: 18%). Histopathologic examination of skin lesions showed perivascular infiltration of immature myeloid cells in the dermis. The infiltrative cells showed positivity for myeloperoxidase. We diagnosed the condition as leukemia cutis from primary myelofibrosis. (Korean J Dermatol 2016;54(10):803∼806)
김연웅 ( Yeon Woong Kim ),김병수 ( Byeong Su Kim ),최진화 ( Jin Hwa Choi ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.1
Kaposi``s sarcoma is an angioproliferative neoplasm that is derived from endothelial cells of blood and lymphatic vessels. Although the etiology is not yet clearly revealed, human herpes virus (HHV)-8 is believed to play an important role in the occurrence of Kaposi``s sarcoma. A 57-year-old man presented with hyperpigmented patches on the right lower leg for 2 months. The patient received a kidney transplantation 19 years ago and has taken immunosuppressants since then. He had undergone a percutaneous coronary intervention twice, and his right lower leg was swollen for a year. We performed a skin biopsy on the right lower leg. Histopathological examination showed neovascularization and vascular dilatation in the dermis with perivascular proliferation of spindle cells. Immunohistochemistry revealed positive findings for CD31 and CD34. An HHV-8 test using polymerase chain reaction (PCR) showed positive findings. We report an interesting case of Kaposi``s sarcoma presenting as hyperpigmented patches with percutaneous coronary intervention-induced lymphedema in an immunosuppressed patient. (Korean J Dermatol 2016;54(1):43∼46)
악성 흑색종과 멜라닌세포 모반에서 WT1의 면역조직화학적 발현양상
김연웅 ( Yeon Woong Kim ),신동훈 ( Dong Hoon Shin ),최종수 ( Jong Soo Choi ),배영경 ( Young Kyung Bae ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.2
Background: Malignant melanomas represent pigmented skin lesions and should be distinguished from melanocytic nevi. However, differential diagnosis of malignant melanomas and melanocytic nevi is often challenging. Wilms` tumor 1 (WT1) protein is a specific immunomarker of Wilms` tumor, and several studies revealed that various malignant tumors have WT1 expression. Objective: The purpose of this study was to evaluate the usefulness of WT1 staining for differentiating malignant melanoma from melanocytic nevi. Methods: We selected 50 cases of melanocytic nevi (12 cases of junctional nevi, 19 of compound nevi, and 19 of intradermal nevi) and 35 cases of malignant melanoma (7 cases of malignant melanoma in situ and 28 cases of invasive melanomas) from clinicopathologically proven cases in the Department of Dermatology of Yeungnam University Medical Center. Immunohistochemistry analysis of WT1 was performed, and the labeling index of WT1 expressions was measured. Results: The mean labeling indices of junctional nevi, compound nevi, intradermal nevi, malignant melanoma in situ, and invasive melanomas were 1.9%±2.8%, 23.6±21.2%, 25.7±23.5%, 5.7±5.2%, and 66.1±32.0%, respectively. The labeling index of malignant melanoma in situ was higher than that of junctional nevi. The labeling index of invasive melanoma was higher than those of compound nevus and intradermal nevus. When the WT1 cut-off point to distinguish melanomas from melanocytic nevi was 27.2%, the sensitivity and specificity were 68.6% and 74%, respectively. When a WT1 cut-off point of 75% was used, the sensitivity and specificity were 40% and 100%, respectively. The mean labeling indices of stages I, II, III, and IV malignant melanoma were 29.5%±30.4%, 68.8%±33.9%, 79.5%±6.4%, and 77.7%±18.8%, respectively, and those of Tis, T1, T2, T3, and T4 were 5.7%± 4.8%, 8.0%±0%, 69.5%±18.5%, 61.9%±28.6%, and 78.6%±30.0%, respectively. Conclusion: WT1 staining could be a potential diagnostic tool for differentiating malignant melanomas from melanocytic nevi because the WT1 labeling indices of melanomas were significantly higher than those of melanocytic nevi. WT1 staining may be helpful in predicting the depth and prognosis of malignant melanomas. (Korean J Dermatol 2017;55(2):96∼103)