과학영재교육의 추진과 현안

김미숙,Kim, Mi-Suk 한국과학기술단체총연합회 2007 과학과 기술 Vol.40 No.5

새로운 정공차폐 층 (Hole blocking layer)으로 DCJTB 도핑된 24MeSAlq를 이용한 백색유기발광다이오드

김미숙,임종태,염근영,Kim, Mi-Suk,Lim, Jong-Tae,Yeom, Geun-Young 한국재료학회 2006 한국재료학회지 Vol.16 No.4

To obtain balanced white-emission and high efficiency of the organic light-emitting diodes (OLEDs), a deep blue emitter made of N,N'-diphenyl-N,N'-bis(1-naphthyl)- (1,1'-biphenyl)-4,4'-diamine (NPB) emitter and a new red emitter made of the Bis(2,4 -dimethyl-8-quinolinolato)(triphenylsilanolato)aluminum(III) (24MeSAlq) doped with red fluorescent 4-(dicyanomethylene)-2-tert-butyl-6-(1,1,7,7-tetramethyljulolidyl-9-enyl)-4H -pyran (DCJTB) were used and the device was tuned by varying the thickness of the DCJTB-doped 24MeSAlq and $Alq_3$. For the white OLED with 10 nm thickness DCJTB (0.5%) doped 24MeSAlq and 45 nm thick $Alq_3$, the maximum luminance of about 29,700 $Cd/m^2$ could be obtained at 14.8 V. Also, Commission Internationale d'Eclairage (CIE) chromaticity coordinates of (0.32, 0.28) at about 100 $Cd/m^2$, which is very close to white light equi-energy point (0.33, 0.33), could be obtained.

식이섬유 수준이 유색육용계의 육질에 미치는 영향

김미숙,문윤희,임사비나,김대진,Kim, Mi-Suk,Moon, Yoon-Hee,Lim, Sabina,Kim, Dae-Jin 한국생명과학회 1997 생명과학회지 Vol.7 No.4

This study was conducted to investigate the effect of dietary fiber(DF) levels on the meat quality in colored broiler. Colored broiler were fed on containing corn-soy basal diet(DF 5%) and high level(DF 6,7 and 8%) of dietary fiber diets for 7 weeks. Dietary fiber level of diet was make up by adding some alffalfa meal. Colored broiler meats were stored at 3$\circ$ for 24hr after skaughter, and used to analyze physico-chemical properties. Proximate component, pH, shear force value, myofibril fragmentation index, water holding capacity, cooking loss, protein extractability, fatty acid composition, Hunter's L, a value and palatability of cooked meat were not significantly affected by dietary fiber levels, whereas the Hunter's value of meat was significantly affected bty dietary fiber levels for the final period of feeding. Crude protein content, myofibril fragmentation index, water holding capacity, protein extractability and Hunter's b value of breast meat's were higher than thigh meat's, but crude fat content, pH, shear force value, cooking loss, palmitoleic acid, linolenic acid, and Hunter's a value were lower, regardless of dietary fiber level.

사람의 신경교종 세포주에서 아데노바이러스 벡터를 이용한 p16/INK4a 유전자 전달에 의한 종양성장 억제

김미숙,권희충,강희석,박인철,이창훈,김창민,이춘택,홍석일,이승훈,Kim, Mi-Suk,Kwon, Hee-Chung,Kang, Hee-Seog,Park, In-Chul,Rhee, Chang-Hun,Kim, Chang-Min,Lee, Choon-Taek,Hong, Seok-Il,Lee, Seung-Hoon 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.4

Objective : p16/INK4a, a kind of tumor suppressor genes, encodes a specific inhibitor of the cyclin D-dependent kinases CDK4 and CDK6. This prevents the association of CDK4 with cyclin D1, and subsequently inhibits phosphorylation of retinoblastoma tumor suppressor protein(pRb), thus preventing exit from the G1 phase. According to previous reports, over 50% of glioma tissue and 80% of glioma cell lines have been demonstrated inactivation of p16/INK4a gene. The purpose of this study was to determine whether recombinant adenovirus-p16 virus is a suitable candidate for gene replacement therapy in cases of glioma. Methods : Three human glioma cell lines(U251MG, U87MG and U373MG) that express mutant p16 protein were used. Replication-deficient adenovirus was utilized as an expression vector to transfer exogenous p16 cDNA into the cells ; control cells were infected with the Ad-${\beta}$-gal expressing ${\beta}$-galactosidase. To monitor gene transfer and the expression of exogenous genes, we used Western Blotting analysis. Flow cytometry studies of cellular DNA content were performed to determine the cell cycle phenotype of the glioma cells before and after treatment. Results : We showed here that restoration of p16/INK4a expression in p16 negative U87MG, U251MG and partially deleted U373MG by Ad-CMV-p16 induced growth suppression in vitro. Flow cytometric study revealed that Ad-CMV-p16 infected U87MG cells were arrested during the G0-G1 phase of the cell cycle. Expression of p16 transferred by Ad-CMV-p16 in glioma cells was highly efficient and maintained for more than seven days. Conclusions : Our results suggest that Ad-CMV-p16 gene therapy strategy is potentially useful and warrants further clinical investigation for the treatment of gliomas.

V+대동여지도_(주)나노텍세라믹스 - 땅을 딛고 온 세계를 누비다

김미숙,Kim, Mi-Suk 벤처기업협회 2009 벤처다이제스트 Vol.129 No.-

기름에도 미끄러지지 않는 신발이 있을까? 있다. 모두가 안 된다고 말할 때, '왜'라고 묻는 생각의 진보가 미끄러지지 않는 장화를 만든느 시작이 되었다. 10년 동안 쌓아온 소재 기술을 바탕으로 최근 'iHAD' 특수 안전 장화를 출시하고 홍보에 잰걸음을 걷고 있는 (주)나노텍세라믹스(대표 정상옥, www.ntcermic.com)을 찾아봤다.

낙동강 부영양화와 수질환경요인의 통계적 분석

김미숙,정영륜,서의훈,송원섭,Kim, Mi-Suk,Chung, Young-Ryun,Suh, Euy-Hoon,Song, Won-Sup 한국조류학회(藻類) 2002 ALGAE Vol.17 No.2

Influences of vrious environmental factors on the eutrophication of Nakdong River were analyzed statistically using water samples collected from 1 January, 1999, to 30 September, 2001 at Namji area. The relationships between the concentration of chlorophyll α (eutrophication index) and environmental factors and were analyzed to develop a statistical model which can predict the status of eutrophication. The concentation of chlorophyll α ranged from 66.2 mg · $m^{-3}$ to 70.8 mg · $m^{-3}$ during dry winter season and the average concentration during this study period was 35.5 mg · $m^{-3}$ Namji area of Nakdong River was in the hypereutrohic stage in terms of water quality. Stephanodiscus sp. and Aulacoseria granulata var. angustissima were dominant species during the witnter to spring time and summer to autumn period, respectively. Based on the correlation analysis and the analysis of variance between chlorophyll α concentration and environmental factors, significantly high positive relationships were found in the order of BOD> pH> COD > KMnO₄ consumption > DO > conductivity > alkalinity. In contrast to these factors, significantly negrative relationships were found as in the order of $PO₄^{3-}-P$ >water level>the rate of Namgang-dam discharge > NH₃-N> the rate of Andong-dam discharge> the rate of Hapchoen-dam discharge. Based on the factors analysis of environmental factors on the concentration of chlorophyll α, we obtained five factors as follows. The first factor included water level, pH, turbiditiy, conductivity, alkalinity and the rate of Namgang-dam discharge. The second factor included water temperature DO, NH₄+-N, NO₃- -N. The third factor included KMnO₄ consumption COD and BOD. The fourth factor included the rate of Andong-dam discharge, the rate of Hapcheon-dam discharge, and the rate of Imha-dam discharge. The final factor included T-N T-P and $PO₄^{3-}-P$ > concentration. We derived two statistica models that can predict the occurrence of eutrophication based on the factors by factor analysis, using regression analysis. The first model is the stepwise regression model whose independent variables are the factors produced by factor analysis : chl α (mg · $m^{-3}$ = 42.923+(18.637 factor 3) + (-17.147 factor 1) + (-12.095 factor 5) + (-4.828 factor 4). The second model is the alternative stepwise regression model whose independent variables are the sums of the standardized main component variables:chl α (mg · $m^{-3}$ = 37.295+(7.326 Zfactor 3) + (-2.704 Zfactor 1)+(-2.341 Zfactor 5).

곡면에 부착 가능한 GPS/GLONASS 마이크로스트립 능동 안테나

김미숙,손석보,주한기,배준성,김준오,Kim, Mi-Suk,Son, Seok-Bo,Joo, Hahn-Kie,Bae, Joon-Sung,Kim, Joon-O 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.1

In this paper, dual-feed circularly polarized microstrip patch antenna for GPS L1, GPS L2, GLONASS L1 signal was fabricated by using stacked patch. It was fed by dual coaxial probe on the patch at 50ohm impedance, and was simulated to resonate at GPS L1, GPS L2, GLONASS L1. To realize characteristics of right hand circular polarization using dual-feed stacked patch antenna and hybrid coupler for $90^{\circ}$ phase difference. Output of hybrid coupler was contacted input of Low Noise Amplifier(LNA). The LNA using dual band pass filter was designed and fabricated. The measured results of the implemented antenna is VSWR < 1.5 : 1 and the gain of 32dB(Zenith) over at GPS L1, L2, GLONASS L1.

암 치료를 위한 보론 중성자 포획치료의 현황

김미숙,Kim, Mi-Suk 한국동위원소협회 1997 동위원소회보 Vol.12 No.4

한국 영재교육, 어디까지 왔으며 무엇이 문제인가- 영재교육 도입 5년 양적.질적성과 긍정적

김미숙,Kim, Mi-Suk 한국과학기술단체총연합회 2008 과학과 기술 Vol.41 No.5

HCMV에 감염된 TBP-1 세포에서 세포간 부착분자-1 발현 촉진물질의 방출

김미숙,이현아,이찬희,Kim, Mi-Suk,Yi, Hyun-Ah,Lee, Chan-Hee 한국미생물학회 2008 미생물학회지 Vol.44 No.2

다양한 염증 질환을 유발하는 사람세포거대바이러스(Human cytomegalovirus: HCMV)는 단핵구 세포주인 THP-1 세포에서 염증반응의 중요한 매개체인 세포간부착분자-1(intercellular adhesion molecule: ICAM-1) 발현을 촉진한다. ICAM-1 발현은 자외선으로 불활화시킨 HCMV (UV-HCMV)에 의해서도 촉진되므로 이 과정에 HCMV 유전자발현은 꼭 필요하지는 않은 것 같다. HCMV에 감염된 THP-1 세포 배양액을 감염되지 않은 THP-1 세포에 처리하거나 공유하게 하였을 시 감염되지 않은 세포에서도 ICAM-1 발현이 증가하였다. 감염된 세포 배양액에 의한 ICAM-1 발현 증가는 $NF-{\kappa}B$ 경로를 거친다. UV-HCMV에 감염된 세포의 배양액은 ICAM-1 발현을 촉진시키지 못하였다. 따라서 HCMV에 의한 THP-1 세포에서 ICAM-1 발현 증가는 바이러스 유전자 발현을 필요로 하지 않지만, 감염된 세포에서 ICAM-1 발현을 촉진하는 물질을 분비하는 과정에는 바이러스 유전자 발현이 필요한 것으로 생각된다. Human cytomegalovirus (HCMV) stimulates the expression of intercellular adhesion molecule (ICAM-l) on the surface of monocytic THP-1 cells. Stimulation of ICAM-l did not require HCMV gene expression since UV-inactivated HCMV (UV-HCMV) was able to induce ICAM-l expression. ICAM-l expression was also stimulated in uninfected THP-l cells which were fed with culture supernatant of HCMV-infected THP-l cells. Co-culture experiment using trans-well insert supported that HCMV-infected THP-l cells secreted some cytokine(s) stimulating ICAM-l expression. The stimulation of ICAM-l by HCMV-infected cell culture supernatant appears to involve $NF-{\kappa}B$ pathway. Culture supernatant from THP-l cells infected with UV-HCMV, whose gene expression was abrogated, failed to stimulate ICAM-l expression on naive THP-l cells. Thus, HCMV gene expression seems to be required in secretion of cytokine(s) stimulating ICAM-l expression.