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인공진피(Terudermis)를 사용한 심부피부 및 연부조직결손에 대한 치료
신준호,야나가(다나베) 히로코,다이 요시아키,기요카와 켄스케,이노우에 요지로,이정형,백봉수 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.5
Various reconstructive procedures have been applied for the skin and soft tissue defect. However, the sacrifice of the donor site in flap surgery and skin grafting and involving problems of deformity or adhesion with underlying tissue in skin have facilitated the development of skin substitute. The history of artificial skin starred in 1980's with the invention of the "Stage I" membrane by Yannas, and Burke. Since then, it has been improved and applied to the clinical cases of extensive burn injury and full thickness skin defect the resection of the nevus. Recently, an artificial dermis(Terudermis), which is composed of fibrillar athelocollagens and heat-denaturated athelocollagens was developed by Terumo Co. Terudermis has the advantage of allowing early incorporation of cellular and vascular components into its collagen sponge due to dehydrothermal cross linking which is very weak. It is very suitable biological material especially in the reconstruction of the deep skin defects without dermis. From Jun 1996 to April 1997, we have grafted this artificial dermis on bony exposures after the trauma in 2 cases, and the deep skin and the soft tissue defects after the release of burn scar contracture in 1 case. Patients follow-up period ranged from 6 months to 10 months. A week after Terudermis grafting neovasculization took place and the granulation tissues appeared in 2-3 weeks. Then the split-thickness skin graft was applied secondarily resulting in the reproduction of enough volume of skin. For this matter, Terudermis is very useful for deep skin defects especially where primary local flap or free flap can not be used.
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