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자궁경부암종에서 인유두종 바이러스 감염, p16INK4A와 p18INK4C유전자 변이 및 세포주기조절 단백의 발현
권경익(Kyung Ik Kwon),김상표(Sang Pyo Kim),서성일(Seong Il Suh),황미열(Mi Yeul Hwang),백원기(Won Ki Baek),권건영(Kun Young Kwon),이상숙(Sang Sook Lee),조치흠(Chi Heum Cho) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4
Objective : We analyzed the gene status of p16INK4A, p18INK4C, the expression of cell cycle associated proteins (p16INK4A, p18INK4C, cyclin D1, CDK4, pRb, and p53), and human papillomavirus (HPV) infection to investigate whether the inactivation of these genes participated in carcinogenesis, and to evaluated the expression of cell cycle associated proteins and HPV infections. Methods : We examined forty-one primary cervical carcinomas (17 adenocarcinomas, 13 keratinizing squamous cell carcinomas, and 11 nonkeratinizing squamous cell carcinomas) using PCR, comparative multiplex PCR, PCR-SSCP, methylation-specific PCR, and immunohistochemistry. Results : Ninety percent of cervical carcinomas showed HPV infection. HPV type 16 was detected in 41% and HPV type 18 was found in 44%. Homozygous deletions at p16INK4A gene were observed in 2 cases, but the mutation of p16INK4A and alterations of p18INK4C gene were not detected. The promoter hypermethylation for p16INK4A in nine cases (31%) of 29 cervical carcinomas was found. Expression of p16INK4A protein was observed in 93% and p18INK4C protein expression was noted in 78%. Positive immunostaining for cyclin D1 was only identified in 5%, whereas positive immunostaining for CDK4 was observed in 95%. Expression of pRb protein was found in 93% and p53 protein in 24% of cervical carcinomas. Conclusion : These results suggest that high risk HPV infections and methylation of the p16INK4A promoter region seem to play an important role in the pathogenesis of cervical carcinomas. Alterations of p18INK4C gene and cyclin D1-CDK4 pathway does not contribute significantly in the cervical carcinogenesis.
불임의 원인으로서의 자궁근종 치료에 있어 GnRH agonist (D-$Trp^6$-LHRH)의 효용에 관한 연구
박세출,권경익,남동호,이민용,임춘근,양숙경,최종무,이두룡,Park, Sae-Chul,Kwon, Kyung-Ik,Nam, Dong-Ho,Lee, Min-Yong,Lim, Chun-Kun,Yang, Sook-Kyung,Choi, Jong-Moo,Lee, Du-Ryong 대한생식의학회 1994 Clinical and Experimental Reproductive Medicine Vol.21 No.1
To evaluate the effectiveness of GnRH agonist for the treatment of uterine myoma as a cause of infertility, fourteen women were recruited to the study. The patients were treated with a delayed-release formulation of D-$Trp^6$-LHRH in biodegradable microcapsules(Decapeptyl-CR), administered intramuscularly at four week intervals for a period of six monthes. The first injection was given on day 21 of the cycle. Serum estradiol levels fell significantly to the mean value of 257.7pgjml 4 weeks after the first injection. Eleven patients in fourteen treated patients had a reduction in the size of uterine myoma as assessed by ultrasonography, two patients had no change of size and one patient had a increase of size. After the first or second injection, all patients became amenorrheic, then resumption of menstruation ocurred at 12 to 14 weeks after the last injection. Common side effects were hot flush, sweating and dyspareunia, whitch were acceptale. In Eleven patients who had a reduction in the size of uterine myoma by treatment with a delayed- release formulation of D-$Trp^6$-LHRH(Decapeptyl-CR), after above treatment with GnRH agonist, then four patients were treated with myomectomy, three patients had pregnancy and full term delivered by Cesarean section. These data suggest that administration of a delayed-release formulation of a GnRH agonist can be a worthwhile and convenient approach to the medical treatment of uterine myoma as a cause of infertility.
Clomiphene citrate에 의한 배란유도 후의 임신율에 관한 연구
임춘근,이민용,권경익,박세출,이두룡,남동호,양숙경 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3
From March 1990 to February 1993, we evaluated completely follow-uped 68 cases of amenorrhea, oligomenorrhea, infertility(anovulation). The ratio of primary to secondary is 31: 37. Ovulation rate and pregnancy rate of 68 cases which were completely treated with clomphene citrate is 72%, 71.8% respectively. Among these 23 pregnat cases, 19 cases were full term delivered, 1 case is ongoing pregnant, and 3 cases were spontaneously aborted. No one of multiple pregnancy and congenital abnormality was noted.
이원주,김택훈,권경익,김종인,조남규,박세출 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.2
저자들은 외형상 여성으로써 원발성 무월경과 양측 외음부 종양 촉지를 주소로 입원한 complete testicular feminization syncrome 1례를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다 The 46, XY individual with complete testicular feminization syndrome is a phenotypic female who is usually somewhat tall, has excellent breast development and presents to the gynecologist because of primary amenorrhea and an inguinal mass. In complete testicular feminization syndrome, axillary and pubic hair are sparse or absent and some degree of virilization such as clitorial hypertrophy, partial labioscrotal fusion and hirsutism doesn't occur at puberty. We report a case of complete testicular feminization syndrome with the brief review of literatures.
Asherman's syndrome 치료 및 난관문합술후의 임신율
권경익,임춘근,박세출,양숙경,이두룡,남동호,이민용 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.1
From November 1989 to October 1993, we treated 11 cases of Asherman's syndrome who had history of laparoscopically tubal sterilization. The mean age was 36.4 years and ratio of positive history of artificial abortion to negative history of artificial abortion is 8 : 3. Initially, we treated Asherman's syndrome by curettage, insertion of 2 Lippes loops. medication of Premarine, Duphastone and then performed microsurgically tubal anastomosis. The pregnancy rate of followed up 10 cases is 80%, of these, 5 cases were full term delivered, 2 cases are ongoing pregnant, 1 case was ectopic pregnant.
서영욱,이상숙,이태성,차순도,권경익,이정호 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.4
The nuclear accumulation of p53 protein is known to correspond with mutation of p53 tumor supressor gene. To investigate the relationship between clinico-pathologic features and expression of p53 mutations, 65 cases of primary cervical carcinoma were analysed by an immunohistochemieal method using monoclonal antibody of p53. Immunostaining demonstrated various nuclear stinings of cancer cells in 48.4% of squamous cell carcinoma(51.9% in large cell carcinoma and 25,0% in small cell carcinomas) and 23.5% of adenocarcinoma(p$lt;0.05) No differences in clinical stage and p53 positivity were found. There was no significant correlation between p53 positive cases and status of recurrence. This data suggests that p53 mutation plays an important role in carcinogenesis of the cervical cancer. The nuclear accumulation of P53 protein is not correlated with the disease progression and prognosis.