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문지영 ( Ji Young Moon ),맹은호 ( Eun Ho Maeng ),박학수 ( Hak Soo Park ),권민 ( Min Kwon ),장동혁 ( Dong Hyouk Jang ),조영민 ( Young Min Cho ),고은옥 ( Eun Ok Koh ),성하정 ( Ha Jung Sung ),박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
Reconstructed skin provides advantages to single cell culture testing and leads to promising results as shown by different validation studies. In this study we investigated the efficacy of "MCTT Skin model" compared with "EPI-200" and in vivo test. We conducted endpoint analysis including cell viability (MTT reduction, CCK-8) and IL-1 alpha release. Sodium lauryl sulfate(20%), Potassium hydoxide(5%), Heptanal, Methyl palmitate, 1,1,1-Trichloroethane, 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazol and Benzyl chloroformate were selected for this comparison. Potassium hydoxide(5%) and Benzyl chloroformate were excluded from animal tests because of their pH. Sodium lauryl sulfate induced severe irritation, Heptanal induced moderate irritation. Methyl palmitate, 1,1,1-Trichloroethane induced mild irritation. 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazole induced no irritation on rabbit skin irritation test. Results of MTT assay and CCK-8 assay were not different between EPI-200 MCTT Skin model but IL-lα levels of some test items different between EPI-200 and MCTT Skin model. We concluded that this MCTT Skin model is useful for alternative skin irritation test, although other tests should be conducted for many other chemicals in international validation study.
문지영 ( Ji Young Moon ),맹은호 ( Eun Ho Maeng ),박학수 ( Hak Soo Park ),권민 ( Min Kwon ),장동혁 ( Dong Hyouk Jang ),조영민 ( Young Min Cho ),고은옥 ( Eun Ok Koh ),성하정 ( Ha Jung Sung ),박철범 ( Cheol Beom Park ) 한국동물실험대체법학회 2007 동물실험대체법학회지 Vol.1 No.1
Reconstructed skin provides advantages to single cell culture testing and leads to promising results as shown by different validation studies. In this study we investigated the efficacy of MCTT Skin model compared with EPI-200 and in vivo test. We conducted endpoint analysis including cell viability (MTT reduction, CCK-8) and IL-1 alpha release. Sodium lauryl sulfate(20%), Potassium hydoxide(5%), Heptanal, Methyl palmitate, 1,1,1-Trichloroethane, 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazol and Benzyl chloroformate were selected for this comparison. Potassium hydoxide(5%) and Benzyl chloroformate were excluded from animal tests because of their pH. Sodium lauryl sulfate induced severe irritation, Heptanal induced moderate irritation. Methyl palmitate, 1,1,1-Trichloroethane induced mild irritation. 2,4-Xylidine, 3,3`-Dithiodipropionic acid, 4-Amino-1,2,4-triazole induced no irritation on rabbit skin irritation test. Results of MTT assay and CCK-8 assay were not different between EPI-200 MCTT Skin model but IL-lα levels of some test items different between EPI-200 and MCTT Skin model. We concluded that this MCTT Skin model is useful for alternative skin irritation test, although other tests should be conducted for many other chemicals in international validation study.