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고광철(Kwang Cheol Koh) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4
Pathophysiologic studies in patients with portal hypertension face many methodologic and ethical difficulties. Therefore, the knowledge of the pathophysiology of portal hypertension is largely based on the results of studies in experimental models. The most commonly used models are rat and murine. It should be emphasized that these models are extremely useful to enhance our understanding of the mechanism and pharmacology of portal hypertension, but they still have limitations and inconvenience. Some of these problems are related to the conditions in which the experiments are performed, the techniques used for hemodynamic measurements, or model-related limitations. These differences should be carefully considered when the results of experimental studies are analyzed, because they may influence the findings of some investigations. (Korean J Gastroenterol 2001;38: 227-232)
고광철 ( Kwang Cheol Koh ) 대한간학회 2012 Postgraduate Courses (PG) Vol.2012 No.-
Since the initial KASL practice guidelines were published, a number of advances have changed our management of variceal bleeding. Nonselective beta-blockers or endoscopic variceal ligation (EVL) are the gold standard in the prevention of first variceal bleeding in patients with esophageal varices. The combination of vasoconstrictive agents and variceal ligation is the preferred approach to the management of acute variceal hemorrhage in addition to prophylactic antibiotic treatment. For failures of pharmacological or endoscopic therapies, transjugular intrahepatic portosystemic shunt (TIPS) is a useful salvage procedure. Management of acute variceal bleeding should be followed by initiating strategies (EVL pharmacological therapy) to lower the risk of rebleeding. Mortality from portal hypertensive bleeding has been markedly diminished by use of these strategies.
고광철(Kwang Cheol Koh),백승운(Seung Woon Paik),이풍렬(Poong Lyul Rhee),김재준(Jae Jun Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),박상종(Sang Jong Park),김영호(Young Ho Kim),최상희(Sang Hee Choi),이순진(Soon Jin Lee),김지은(Je 대한내과학회 1999 대한내과학회지 Vol.57 No.3
The purposes of this study were to assess the relationship between functional dyspepsia (FD) and the gastroptosis which was considered as one of the causes of FD by some physicians in Korea and to evaluate the possibility that gastroptosis was directly related to the relatively decreased abdominal fat content. Methods : 442 subjects taken upper gastrointestinal barium series (UGIS) for routine check-up were interviewed about symptoms of FD by physicians on the basis of Rome criteria. Various parameters of obesity were also collected from 366 subjects. Gastroptosis was diagnosed by radiologists when the gastric angle was located below the Jacobys line. Results : Gastroptosis was found in 23 (5.2%) of 442 subjects. Relationship between gastroptosis and FD was rejected statistically because 3 (5.8%) of 52 subjects with FD had gastroptosis but 20 (5.1%) of 390 subjects without FD also showed gastroptosis. Various parameters of obesity such as body mass index (20.6±2.6, 23.8±2.8), % body fat (23.4±6.1%, 28.2±6.6%), % ideal body weight (97.9±12.6%, 112.6±14.0%), waist to hip ratio (0.855±0.096, 0.900±0.070) and weight (53.5±8.2 kg, 62.5±9.6 kg) in subjects with and without FD showed that the gastroptosis was more frequent in subjects with low values in parameters of obesity. But on multivariate analysis, only body mass index was the independent factor related to gastroptosis. Conclusion : Gastroptosis is not a cause of FD but is thought to be a constitutional problem related to low values in parameters of obesity. (Korean J Med 57:298-303, 1999)
B 형 만성 간염 환자에서 HBeAg / anti - HBe 전환 전후에 HBV Precore 변종의 발생과 만성 간염 활동성과의 관계
고광철(Kwang Cheol Koh),이효석(Hyo Suk Lee),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Objectives: To determine the most common type of precore mutant of hepatitis B virus (HBV) and the relationship between the emergence of precore mutant and the severity of chronic hepatitis B, we compared the prevalence and the emerging pattern of the precore mutant during the natural course in chronic-hepatitis-B patients, with us well as without biochemical remission, along with HBeAg/anti-HBe seroconversion. Methods: A total number of 39 sera obtained serially from 12 patients with chronic hepatitis B, all of whom experienced HBeAg/anti-HBe seroconversion during natural course were studied. The patients were divded into two groups according to the subsequent biochemical remission after HBeAg/anti-HBe seroconversion; Group I included 8 patients who accompanied biochemical remission and group II 4 patient-s who showed persistent elevation of ALT. The prevalence rates of precore mutant of these two groups and the rates before and after HBeAg/anti-HRe seroconversion were compared with each other. The sera were analysed for the presence of mutation at the precore region of HBV using the direct sequencing of DNA amplified by polymerase chain reaction. Results: The precore mutants were found in 10 patients (83.3%) of a total number of 12 patients; 6 of 8 (75.0%) in group I and 4 of 4 (100%) in group II. The difference in the detection rates between the two groups was not statistically significant (p=0.52). The precore mutant having a G-A mutation at the nucleotide 1896 was most commonly found (9/10), and the precore mutant with G-A mutations both at the nucleotide 1896 and 1899 was also found in the remaining one patient. The detection rates of wild type were 75.0% (9/12) during HBeAg-positive period and 0% (0/7) during anti-HBe-positive period. In contrast, those of precore mutant were 66.7% (8/12) during HBeAg-positive period and 100g (7/7) during anti-HBe-positive period. In 2 patients, the courses of whom were closely followed up for longer period of time, wild type was the predominant population of HBV in sera during HBeAg-positive period when the values of ALT fluctuated, and precore mutant began to emerge just before the disappearance of HBeAg and was the main population after the ALT level normalized and anti-HBe became positive. Conclusion: The most common type of precore mutant of HBV in Korea was the mutant with a G-A mutation at nt 1896. The emergence of precore mutant was frequently associated with the HBeAg/anti-HBe seroconversion irrespective of ALT levels; therefore, precore mutant is unlikely to bear direct causal relation to the severity of chronic hepatitis B.
김재준(Jae Jun Kim),고광철(Kwang Cheol Koh),김태호(Tae Ho Kim),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Objectives: The effect of continued supplementation of diet with 10gp sucrose, lactose or glucose solution on rat intestinal disaccharidase specific activity was investigated. Methods: Adult rats were fed a diet with 10% sucrose, lactose or glucose solution supplementation. After 6 weeks, small intestines were removed and disaccharidase specific activities and sucrose mRNA levels were measured. Results: Adult rats when fed a diet with 10% sucrose, lactose or glucose solution supplementation for 6 weeks showed increased intestinal sucrose sperific activity. However, there was no increase of lactase specific activity. Slot blot analysis with radiolabeled rat intestinal sucrase cDNA revealed that mRNA levels of sucrase increased after 10% sucrose, lactose or glucose solution supplementation, and these changes in mRNA levels correlated with the corresponding enzyme specific activity (r=0.36, p<0.05). Conclusion: The results demonstrate that the induction of sucrase activity is directly associated with an increase in sucrase mRNA levels. In conclusion, substrate feeding induces an increase of transcription of rat intestinal sucrase gene.
우리나라 원발성 간세포암 조직에서 중합효소 연쇄반응을 이용한 B 형 간염 바이러스 DNA 의 검출
이계희(Kye Heui Lee),고광철(Kwang Cheol Koh),이효석(Hyo Suk Lee),송인성(In Sung Song),김정룡(Chung Yong Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.3
Objectives : The advances in molecular biological technique enable us to detect the integrated HBV DNA in the chromosomal DNA of hepatocellular carcinoma (HCC) cells by Southern blot analysis. The recent development of the polymerase chain reaction made possible the detection of single-copy HBV DNA in a hepatocyte. Regarding the oncogenesis of HBV-related HCC, X-gene is highly suggested to be oncogenic in a transgenic mice model. We investigate the detection rate of each HBV subgenome in the HCC tissues to approach to the human hepatocarcinogenesis using the most sensitive polymerase chain reaction (PCR). Methods: Thirteen formalin-fixed paraffin-embedded HCC-tissue blocks which were aseptically obtained by surgical resection in Korea were studied; 10 were positive for serum HBsAg and one was positive for serum anti-HBc alone, and two were negative for all HBV serological markers. Cellular DNA was extracted from a deparaffinized slice of each tissue block, and then each subgenomic HBV DNA was amplified by PCR using a pair of primers corresponding to each subgenome. The amplified HBV DNA subgenomic fragment was detected by Southern blot hybridization. Results : Among 10 HBsAg-positive cases, the s-gene, c-gene and x-gene nucleotide sequences were detected in 5(50%), 4(40%) and 9(90%) cases, respectively, All 3 gene sequences were detectable in 4(40%) cases. However, HBV DNA subgenomic fragment was not found in the anti-HBc-only case and the cases without any HBV serological marker. Conclusion: It was concluded that HBV may not be involved at all in the development of HBsAg-negative HCC while HBV, especially x-gene, played a major etiologic role in HBsAg-positive HCC in human hepatocarcinogenesis.