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Ouabain이 摘出병아리 網膜의 網膜電位圖 C-파에 미치는 效果
金夏卿,佐藤匡,米山高仁,田澤豊,具本術 중앙대학교 의과대학 의과학연구소 1988 中央醫大誌 Vol.13 No.1
Noradrenaline, a stimulant of the adenylate cyclase, augmented c-wave as much as ouabain and this effect was largest at 10^-9M. After augmentation of the c-wave by 10^-9 noradrenaline, there was no additional augmenting effect of 10^-7M ouabain. This fact suggests that the ouabain-induced augmentation of the c-wave may be due to the stimulation of adencylate cyclase. In the presence of 10^-7M ouabain, the light sensitivity of retina was elevated to 0.5 log unit and it was increased about 30% over the maximum response. This may be one of the signs of visual complications caused by ouabain, such as metachromatopsia. The effect of ouabain on the ERC c-wave was investigated in the isolated chick retina. Although the c-wave was abolished by a high dose of ouabain (10^-4M), it increased in amplitude in the presence of ouabain at a low concentration of 10^-7M, which was within the therapeutic range of clinical use for cardiac glycoside. The standing potential of the retina did not change appreciably until 10^-6M order and then decreased gradually at higher concentrations. In the presence of 10^-4M ouabain, the level having a complete blocking effect of Na-K ATPase, both the c-wave and the standing potential were almost abolished. These effects of ouabain were more conspicuous when the drug was applied to the vitreous side than to the choroidal side.
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