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藥用Sulfonamide 類의 Schiff 監基의 合成과 抗菌作用
金鍾潤,張億奎,田應鎬 嶺南大學校府設 基礎科學硏究所 1983 基礎科學硏究 Vol.3 No.-
Twelve new Schiff bases were synthesized by condensation of two kinds of medicinal sulfonamides with eight kinds of aromatic aldehydes. They were identified by means of the elemental analysis, and UV and IR spectrochemical analyses. Antibacterial activity of the Schiff bases was tested in vitro against one gram-positive and seven gramnegative bacterial species. The results show that some of the compounds are more effcetive than each of corresponding sulfonamides against gram-positive St. aureus, exerting more remarkable activity compared to that against the gram-negative species. Therefore, the mechanism of action of the Schiff bases seems to be different from that of medicinal sulfonamides.