전립선특이항원 선별검사 도입에 따른 전립선암의 임상병리학적 특성의 변화

권종규,장인호,김태형,명순철 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.5

PURPOSE: The aim of this study was to investigate the changes in the clinical and prognostic parameters of prostate cancer in Korean men in the eras before and after prostate-specific antigen (PSA) testing. MATERIALS AND METHODS: The medical records of 303 patients treated for prostate cancer between 1982 and 2005 were reviewed with respect to age, chief complaints, clinical stage, tumor grade, treatment options, and prognosis. We classified the patients as follows: those treated in the pre- PSA era (1982-1995, n=81), and those treated in the PSA era (1996-2000, PSA era phase 1, n=92; and 2001-2005, PSA era phase 2, n=130). RESULTS: There was no significant difference in age or clinical stage between patients treated before and those treated during the PSA era, although there was a downward migration of grade. The cancer-specific survival rates were also not different in all cases and in metastatic prostate cancer cases between the pre-PSA era and the PSA era, although the overall survival rates were significantly greater in all cases in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p<0.05). However, the cancer-specific survival rates for localized or locally advanced prostate cancer were significantly greater in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p<0.05). CONCLUSIONS: We observed a downward migration of tumor grade, but there were no migrations in the age of patients or clinical stage, and these findings have not contributed to changes in the cancer survival of Korean men with prostate cancer after the advent of PSA testing. PURPOSE: The aim of this study was to investigate the changes in the clinical and prognostic parameters of prostate cancer in Korean men in the eras before and after prostate-specific antigen (PSA) testing. MATERIALS AND METHODS: The medical records of 303 patients treated for prostate cancer between 1982 and 2005 were reviewed with respect to age, chief complaints, clinical stage, tumor grade, treatment options, and prognosis. We classified the patients as follows: those treated in the pre- PSA era (1982-1995, n=81), and those treated in the PSA era (1996-2000, PSA era phase 1, n=92; and 2001-2005, PSA era phase 2, n=130). RESULTS: There was no significant difference in age or clinical stage between patients treated before and those treated during the PSA era, although there was a downward migration of grade. The cancer-specific survival rates were also not different in all cases and in metastatic prostate cancer cases between the pre-PSA era and the PSA era, although the overall survival rates were significantly greater in all cases in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p<0.05). However, the cancer-specific survival rates for localized or locally advanced prostate cancer were significantly greater in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p<0.05). CONCLUSIONS: We observed a downward migration of tumor grade, but there were no migrations in the age of patients or clinical stage, and these findings have not contributed to changes in the cancer survival of Korean men with prostate cancer after the advent of PSA testing.

도덕 교육의 방법론 : 가치명료화 도덕교육의 이론과 수업적용 The Theory of Value Clarifying Moral Education & Its Classroom Application

정보주,권종규 晋州敎育大學校 初等敎育硏究所 1993 初等敎育硏究 Vol.3 No.-

혈액 담즙증을 동반한 황색육아종성 담낭염 및 담낭암 2예

권종규,김대진,류현욱,설수환,황병식,박종훈,손경락 대한소화기내시경학회 2011 Clinical Endoscopy Vol.42 No.6

Hemobilia is a rare upper gastrointestinal (GI) bleeding phenomenon usually caused by trauma but may occur due to various liver and pancreatobiliary diseases. Causes related to gallbladder disease include vascular disorders, malignancy, polyps, heterotopic GI mucosa, acalculous inflammation, and most commonly gallstones. Most cases are treated with a cholecystectomy. If hemobilia is detected, efforts must be made to exclude malignancy because hemobilia develops from both benign and malignant disease. Particularly in gallbladder disease with hemobilia, the possibility of gallbladder carcinoma should be considered. We report two cases of hemoblia by endoscopic retrograde cholangiopancreatography and duodenoscopy, with a review of the literature. The first case was xanthoglanulomatous cholesystitis and the second case was gallbladder cancer disclosed by cholecystectomy. 혈액 담즙증은 드문 상부 위장관 출혈의 한 형태로 주로 외상에 의해 발생하나 다양한 간 및 췌담도 질환에 의해 발생할 수 있다. 담낭질환과 관련하여 발생하는 경우는 혈관질환, 종양, 용종, 이형성 위점막, 무담석 염증 등이 있으나 담석에 의해 발생하는 것이 가장 흔하며 대부분 담낭절제술로 치료한다. 양성 및 악성 질환 모두에서 발현 될 수 있으므로 혈액 담즙증이 진단된 경우에는 악성 질환을 배제 하려는 노력이 필요하며 담낭질환의 경우 반드시 담낭암의 가능성을 생각하여야 한다. 저자들은 상복부 통증과 혈액 담즙증이 있어 수술적 치료로 확인된 드문 황색 육아종성 담낭염과 담낭암 두 증례를 경험하여 문헌 고찰과 함께 보고한다.

Pain, Catastrophizing, and Depression in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

권종규,장인호 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.2

Persistent and disabling pain is the hallmark of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). However, disease severity (as measured by objective indexes such as those that use radiography or serology) is only marginally related to patients’ reports of pain severity, and pain-related presentation can differ widely among individuals with CP/CPPS. Increasing evidence in support of the biopsychosocial model of pain suggests that cognitive and emotional processes are crucial contributors to inter-individual differences in the perception and impact of pain. This review describes the growing body of literature relating depression and catastrophizing to the experience of pain and pain-related sequelae in CP/CPPS. Depression and catastrophizing are consistently associated with the reported severity of pain, sensitivity to pain, physical disability, poor treatment outcomes, and inflammatory disease activity and potentially with early mortality. A variety of pathways, from cognitive to behavioral to neurophysiological, seem to mediate these deleterious effects. Collectively, depression and catastrophizing are critically important variables in understanding the experience of pain in patients with CP/CPPS. Pain, depression, and catastrophizing might all be uniquely important therapeutic targets in the multimodal management of a range of such conditions.

전립선비대증 환자에서 방광경부의 조직탄성도가 하부요로 증상에 미치는 영향

권종규,정해도,조강수 대한비뇨기종양학회 2019 대한비뇨기종양학회지 Vol.17 No.3

Purpose: We evaluated the impact of bladder neck stiffness on lower urinary tract symptoms in the patient with benign prostatic hyperplasia using elastography. Material and Methods: A total of 384 patients divided into three different groups according to the bladder neck stiffness based on ultrasound with elastography. Patients age, prostate specific antigen (PSA), International Prostate Symptom Score (IPSS), prostate volumetric parameters, residual urine volume, and laboratory data were collected and compared among the three groups. Results: Group 1 (n=121) showed low stiffness in both bladder neck adenoma. Group 2 (n=157) showed low to intermediated stiffness, and group 3 (n=106) showed significantly higher stiffness of bladder neck and adenoma compared to adjacent prostatic tissue. Significant differences among the 3 groups were found in the total prostate volume, transition zone volume, transition zone index, total IPSS, IPSS-voiding, IPSS-storage, residual urine volume, and quality of life. As the stiffness increased, prostate volumetric parameters, and residual urine volume were increased, and lower urinary tract symptoms became exacerbated. No significant difference was found in the patients’ age and PSA. Conclusions: Bladder neck stiffness affected the lower urinary tract symptoms and prostate volumetric parameters. These findings suggest that the change of bladder neck stiffness can be a novel parameter for the development of lower urinary tract symptoms/benign prostate hyperplasia.

담즙찌꺼기를 동반한 급성 췌장염으로 우연히 진단된 췌장의 점액성 비낭성 샘암종

권종규,류현욱,김현수,이정안,손경락 대한내과학회 2010 대한내과학회 추계학술발표논문집 Vol.2010 No.-

수막염을 합병한 폐렴알균 심내막염

권종규 ( Jong Kyu Kwon ),권혁용 ( Hyuck Yong Kwon ),은동엽 ( Dong Yeub Eun ),이재광 ( Jae Gwang Lee ),이경숙 ( Kyoung Suk Lee ),최진우 ( Jin Woo Choi ),권기태 ( Ki Tae Kwon ) 대한내과학회 2010 대한내과학회지 Vol.78 No.1

Streptococcus pneumoniae is an infrequent cause of infective endocarditis in the penicillin era. This infection typically follows pneumonia in the setting of chronic alcoholism and may be complicated by meningitis. Only one adult case of pneumococcal endocarditis (PE) has been reported in Korea. We report the case of a 73-year-old woman who suffered from PE complicated by embolic cerebral infarction and meningitis. This is the first Korean case of PE complicated with meningitis. The patient was treated medically and died from a cardiac complication. This case shows that PE is difficult to treat without surgery because its evolution is usually acute and very aggressive; it has a high rate of local and systemic complications despite the administration of appropriate antibiotics. (Korean J Med 78:138-143, 2010)

비뇨기과 영역에서의 복강경 부신절제술

권종규(Jong Kyou Kwon),오철규(Cheol Kyu Oh) 대한비뇨기종양학회 2015 대한비뇨기종양학회지 Vol.13 No.1

Laparoscopic adrenalectomy has been the standard method for resecting adrenal gland tumors. Recently, laparoscopic retroperitoneal adrenalectomy (RA) has been more popular than conventional transperitoneal laparoscopic adrenalectomy (TLA) as an alternative method. Studies comparing laparoscopic RA and TLA showed that laparoscopic RA was superior or at least comparable to TLA in operation time, blood loss, pain score, hospital stay, and return to normal activity. Conversion rates and complication rates were similar. At present, laparoscopic RA has been int the limelight procedure for patients with benign adrenal disease. However, surgeons have been reluctant to offer this operation to patients because of the concerns over inadequate working space and overall perceived higher rate of complications, laparoscopic RA is not popular in urologic field up to now. This article summarizes the latest ideas and issues on laparoscopic RA in the expanding field of laparoscopy in urology.

요로감염에서 활성화되는 분자방어기전의 최신 지견

김정훈,권종규,장인호 대한요로생식기감염학회 2013 Urogenital Tract Infection Vol.8 No.2

Mucosal tissues in the gastrointestinal tract are exposed to a significant number of microorganisms, many of which present a danger to the host. In contrast, the urogenital tract is colonized rather infrequently with bacterial organisms and devoid of physical barriers such as a multi-layered mucus or ciliated epithelia, thereby necessitating separate host defense mechanisms. Recurrent urinary tract infection (UTI) represents successful microbial host evasion and poses a major health problem. In recent years, considerable advances have been made in our understanding of the mechanisms underlying the immune homeostasis of the urogenital tract. The system of pathogen-recognition receptors, including the Toll-like receptors, is able to sense danger signaling and thus activate the host immune system of the genitourinary tract. Various soluble antimicrobial molecules, including iron-sequestering proteins, defensins, cathelicidin, and Tamm-Horsfall protein, have been more clearly defined. In addition, involvement of signaling mediators such as cyclic adenosine monophosphate or the circulatory hormone vasopressin in the defense of uropathogenic microbes and maintenance of mucosal integrity has been demonstrated. Beyond this, specific receptors that are hijacked by uropathogenic Escherichia coli in order to enable invasion and survival within the urogenital system, paving the way for chronic forms of UTI, have been identified. The majority of these findings offer novel avenues for conduct of basic and translational research for development of effective therapies against the diverse forms of acute and chronic UTI.

Toluidine Blue-O를 이용한 Dnase activity에 관한 연구

최승구,권종규,박인재 대한임상병리사협회 1987 임상병리사회지 Vol.19 No.1