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Nitric Oxide Modulates Calcium Current in Cardiac Myocytes but not in Intact Atrial Tissues
박춘옥,강영진,이회영,장기철,Park, Choon-Ok,Kang, Young-Jin,Lee, Hoi-Young,Chang, Ki-Churl The Korean Society of Pharmacology 1995 대한약리학잡지 Vol.31 No.3
본 연구의 목적은 외부에서 nitric oxide (NO)를 투여 하였을때 심근 수축력, 심박동수의 변화 및 혈관 평활근에 대한 효과를 비교함으로서 NO에 대한 이들 장기의 민감도가 서로 같은지 또는 상이한지를 알아보고자 하였다. 본 실험에서는 PIANO 방법에 의한 근장력의 변화와 아울러 심근에서의 $Ca^{2+}$ current를 측정하였다. 랫트의 심방근에 대한 PIANO $(STZ,\;100\;{\mu}M)$는 심근수축력 및 심박동수에 전혀 변화를 주지 않았지만 혈관 평활근에서는 강한 이완 작용을 나타내었다. 한편, 8-Br-cGMP도 고농도 $(100\;{\mu}M)$에서만 심근 수축력을 억제하였다. 토끼의 심방근세포에서 Whole cell voltage patch clamp를 사용시 bradykinin, SNP, 8-Br-cGMP 및 PIANO는 $Ca^{2+}$ current를 억제하였다. 이러한 사실은 외부에서 공급되는 NO에 대한 심근과 혈관 평활근의 반응에는 민감도의 차이가 있음을 암시하며 더 나아가 심근의 경우에도 NO 반응에는 종 (species)간의 차이와 동일 종이라 하더라도 세포(cell)와 장기(tissue)에 차이가 있을 가능성을 제시하였다. The aim of the present study was to know whether exogenously administered nitric oxide (NO) may differently modulate muscle mechanics between heart and aorta. We used PIANO method to generate NO. In isolated rat atrial tissues, neither heart rate nor contractility was affected by PIANO $(STZ,\;30{\sim}100\;{\mu}M)$. Only high concentration $(100\;{\mu}M)$ of 8-bromo cyclic GMP slightly depressed cardiac contractility. However, the same concentrations of 8-Br cGMP and PIANO significantly relaxed the rat thoracic aorta contracted with phenylephrine $(0.1\;{\mu}M)$. In isolated rabbit cardiac atrial myocytes, the amplitude of calcium currents were decreased in the whole voltage range by the presence of streptozotocin, which was further potentiated by UV light. Calcium currents were also decreased in those preparations treated with bradykinin, nitroprusside and 8-Br cGMP. These findings suggest that exogenous NO may modulate calcium current in cardiac myocyte. However, it remains why this does not affect myocardial contractility and heart rate. We concluded that NO may differently regulate calcium signal between aorta and heart muscle.
카드뮴 축적균주인 Aeromonas hydrophilia HG-3의 분리동정 및 특성
박춘옥 亞成出版社 1993 釜山女子大學 論文集 Vol.15 No.-
In order to remove 0 cadmium from waste water, this study was designed to the characteristics of cadmium accumulating strains isolated from waste sludge. A strain HG-3 was isolated waste sludge which showed a highest activity of cadmium accmulation among isolated strains. The morphorogical and physiological properties of strain HG-3 were carried out according to Cowan & MacFaddin's identification shemas and API system. The strain HG-3 was ascribe the Aeromona hydroiphilia HG-3. The medium pH was 7.0, and optimum temperature was 20-25℃. Aeromona hydroiphilia HG-3 not appeared the ingibition of growth on addition of various heavy metal such as Pb²?, Cu²?, Zn²?, Sn²? and Cr?, but H양 was inhibited. The removal efficiency was 43.4 % when it was cultivated in the media containing cadmium ion of 10ppm.
카드뮴 축적균주인 Aeromonas hydrophilia HG-3의 분리동정 및 특성
박춘옥 부산여자대학 1993 釜山女子專門大學 論文集 Vol.15 No.-
In order to remove 0 cadmium from waste water, this study was designed to the characteristics of cadmium accumulating strains isolated from waste sludge. A strain HG-3 was isolated waste sludge which showed a highest activity of cadmium accmulation among isolated strains. The morphorogical and physiological properties of strain HG-3 were carried out according to Cowan & MacFaddin's identification shemas and API system. The strain HG-3 was ascribe the Aeromona hydroiphilia HG-3. The medium pH was 7.0, and optimum temperature was 20-25℃. Aeromona hydroiphilia HG-3 not appeared the ingibition of growth on addition of various heavy metal such as Pb²⁺, Cu²⁺, Zn²⁺, Sn²⁺ and Cr⁺, but H양 was inhibited. The removal efficiency was 43.4 % when it was cultivated in the media containing cadmium ion of 10ppm.
박춘옥 부산여자대학 1988 釜山女子專門大學 論文集 Vol.10 No.-
Green tea was extracted with hot water and precipitated with ethanol to obtained a crude protein-polysaccharide fraction. The polysaccharide components galactose, fructose, xylose and mannose, and the protein components glycine, aspartic acid, serine and threonine were isolated from the crude protein-polysaccharide fraction by GC and Amino Acid Autoanalyzer. The antitumor effect of the protein-polysaccharide fraction were tested by the s이d tumor growth inhibition test against Sarcoma-180 implanted in ICR mice. When the protein-polysaccharide fraction was administered i.p. at the dose of 50 and 100mg/kg/day for 10 consecutive days to the male ICR mice, which had been implanted with 1×106 cells of Sarcoma-180 24 hours before the first injection of protein-polysaccharide fraction. It showed inhibition ratio of 47.15 % and 52.47 %
녹차 추출물이 Streptozotocin 유발 쥐의 당뇨병 및 항암효과
박춘옥 부산여자대학 1997 釜山女子專門大學 論文集 Vol.19 No.-
The present study was undertaken to compare the functional characteristics of green tea hot water extracts on streptozotocin(STZ) induced diabetic rats and inhibition of antitumor activity toward Sarcoma-180 bearing mice. Serum glucose content by administration to the green tea crude catechin extracts and hot water extracts were maintained with normal state than that of control. Phospholipid and triglyceride contents were significant decreases in group of administration with green tea catechin extracts and hot water extracts than that of control groups. Total cholesterol, LDL+ VLDL cholesterol and atherosclerotic index were decreased in the group of treatment of green tea samples when dose level compared with that of control group. On the other hand, the growth inhibition of the Sarcoma -180 showed the highest level of 67.87% when 100mg/kg green tea hot water extracts administrated. The life prolongation effectt by green tea crude catechin extracts.
구조물의 다목적퍼지 최적화에 관한 연구 ( A Study on Multi-objective Fuzzy Optimization of Structures )
박춘옥,편해완,김명선,강문명 대한건축학회 1998 大韓建築學會論文集 : 構造系 Vol.14 No.9
최적설계문제에서 목적식을 더욱 만족시키기 위해서는 제약조건식을 더 많이 깨뜨려야 하므 로 목적함수식과 제약조건식은 대립되는 기준의 집합을 형성한다. 최적설계는 이러한 대립 되는 기준들을 균등하게 달성시키는 것으로 표현될 수 있다. 여기에는 단일목적보다는 다목적퍼지최적개념의 도입이 더욱 바람직하다. 따라서 본 연구에 서는 다목적 퍼지최적문제의 만족스런 해를 구하기 위해 퍼지성을 고려하여 목적함수와 제 약식을 소속함수로 구성하였다. 퍼지의사결정에는 교의사결정을 이용하였으며 제약식은 한계상태설계법에 의해 구성되어졌 고 설계예는 양단고정보와 7부재트러스 모델을 다목적 퍼지최적화하였다. 목적함수는 중량 및 체적과 중앙처짐을 두었다. 본 연구를 통해서 기존확률론의 개념으로는 다룰 수 없었던 모호한 주관성을 포함하는 실무 기술자의 경험과 판단 및 시공성의 불확실성을 퍼지집합이론을 도입하고 다목적 퍼지최적화 문제를 일반적인 최적화문제로 전환시켜 합리적인 최적값을 구할 수 있을 뿐만 아니라 일 반최적화보다 구조물의 실제거동에 더욱 근접한 최적설계를 할 수 있다고 판단된다.
GS-386이 단일 심근 세포의 Ca<sup>2+</sup> 전류에 미치는 효과
박춘옥,장경재,김양미,한재희,홍성근,Park, Choon-ok,Chang, Kyeong-jae,Kim, Yang-mi,Haan, Jae-hee,Hong, Seong-geun 대한수의학회 1994 大韓獸醫學會誌 Vol.34 No.1
The effects of the novel compound GS-386 on the calcium current were investigated in rabbit atrial myocytes. The calcium current was recorded during various depolarizations of 200 ms duration from a holding potential of -40 mV using the whole cell patch clamp technique. The calcium current was activated from -30 mV, reached maximum amplitude at +10 mV and almost disappeared at +50 mV. Superfusion of GS-386 led to a reduction of the calcium current amplitude dose-dependently and $ED_{50}$ was $2.5{\times}10^{-7}M$. But the dependence of the calcium current on the membrane potential was not altered by GS-386. The inactivation of the calcium currents showed single exponential curves in both before and after application of GS-386. The inactivation time constants before and after application of GS-386 were almost the same(35 ms and 32.5 ms). The steady-state inactivation curve of the calcium current was not shifted by GS-386. The calcium currents both before and after application of GS-386 recovered completely in 1 sec and the recovery time constants were about 200 ms in both cases. From the above results it is concluded that the novel compound GS-386 has calcium antagonistic property decreasing the calcium current.