Vinyl 被覆이 Tulip의 生育 및 子球生産에 미치는 影響

朴祺培 안성산업대학교 1988 論文集 Vol.20 No.-

本, 實驗은 Tulipa gesneriana L.國內生産의 基礎자료를 얻기 위해 'Red Matodor'와 'Apeldoorn' 2個 品種을 供試하여 1987年 가을부터 1988年 늦봄까지 品種別로 본 10月 30日 被覆(vinyl mulchingⅠ), 1월 30일 被覆(vinyl mulchingⅡ), 1月 30日 tunnel設置(vinyl tunnel)가 生育, 開花, 子球生産에 미치는 影響을 검토한 바 다음과 같은 結果를 얻었다. 1. vinyl tunnel區가 溫度上昇이 너무 높았고, 두 品種 共히 첫 發芽日, 첫 開花日도 따라서 가장 빨랐다. 2. 葉數, 球高, 球徑은 두 品種 共히 處理間에는 별 차이가 없었고, 葉長, 葉幅, 花梗長은 vinyl tunnel區가 가장 길었다. 3. 'Red Matodor'및 'Apeldoorn'두 品種 共히 子球生産에 있어 vinyl mulchingⅠ 및 Ⅱ구 (10月 30日과 1月 30日 被覆)에서 全體 收量 및 個當 重量이 많았고 無被覆區의 가장 큰 子球보다 크거나 무거웠으며, vinyl mulching을 早期에 한 것(vinyl mulchingⅠ)이 後期에 한것(vinyl mulchingⅡ)보다 多少 球根肥大를 助長하는 結果를 가져왔다. 4. 以上의 結果를 綜合하면, vinyl mulching으로 tulip의 球根肥大를 促進시킨것은, 球根肥大에 對한 溫度의 好條件을 長期間 附與한 까닭으로 생각된다. The present experiments dealt exclusively with obtaining information on possible improvement for the production of Tulipa gesneriana bulblet quality under the natural field conditions of Korea today. Two cultivars, 'Red Matador' and 'Apeldoorn' were subjected to study for the effect of vinyl mulchings and vinyl tunnel treatments on the growth, flowering and especially bulblet production during the ordinary growing period of tulips. The results obtained through the experiment are summarized as in the following; 1. The highest temperature surrounding the plant was noticed at vinyl tunnel, and the vinyl tunnel treatment expedited the bud emergence above the ground and the flowering. The grwoth thus exhibited 17 for 'Red Matador' and 23 fays faster for 'Apeldoorn' than without the vinyl. 2. As to growth, the two cultivars concurrently showed more leaves with vinyl mulching than without and greater leaf length, leaf width and length of flower stalk of tulips at vinyl tunnel than without vinyl mulchings. 3. Vinyl mulching irrespective of the time of treatment produced greater number of bulblets (sizing more than the original mother bulb) than without the mulching and any other treatment, indicating the fact that the vinyl mulching permits to extend mush favorable temperature conditions for bulblet were produced with vinyl mulchings executed then mother bulbs were planted in the fall, and this was particularly outstanding for 'Apeldoorn'. Number and fresh weight of bulblets produced was also greatest with vinyl mulching dome at the time of bulb planting in the fall, than vinyl mulching done in the early spring, without vinyl mulching(control), and vinyl tunnel treatment, in that order. The bulblet production was least with the vinyl tunnel among others as in the case of without vinyl-mulching treatments and the control as well. 4. The overall experimental results have manifested that a high temperature environment in the vinyl tunnel causes mush earlier bud emergence above gthe ground and earlier flowering, and the least bulblet production is apparent as compared to that without vinyl mulchings, yet vinyl mulching in the open field ground resulted in producing relatively superior individual bulblets when considered the original mother bulb. The superiority is probably due to the extension of the adequate temperature longer lasting in the climate for the bulblet growth than without the vinyl.

약국관리 대행업이 국내에 미칠 영향과 대책

박기배 약사공론 1992 대한약사회지 Vol.1992 No.4

아지도싸이미딘의 지속성방출형담체로서의 소수성시클로덱스트린유도체

박기배,이광표,서보연 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2

This study has been undertaken to evaluate hydrophobic cyclodextrin(CD) derivatives as a sustained release carrier of azidothymidine(AZT). AZT. which has potent activity against AIDS and AIDS-related complex as thymidine analogue, has been reported that it has significant toxicity and short half life. Therefore, it is necessary to design sustained release oral dosage form to avoid undesirable side effects attributable to an excessive plasma concentration and to reduce the frequency of administration of AZT. Inclusion complexes of AZT with acetyl-β-cyclodextrin (ACβCD) and triacetyl-β-cyclodextrin(TAβCD) were prepared by solvent evaporation methcd. Interactions of AZT with CD were investigated by Differential Scanning Calorimetry(DSC) and Infrared Spectrophotometry(IR). The decreasing order of water solubilities of AZT and AZT-CD inclusion complexes were as follows: AZT (27.873±0.015,㎎/㎖)) AZT-ACβCD (3.377±0.03) > AZT-TAβCD (2.528±0.001). Partition coefficients of AZT-ACβCD and AZT-TAβCD inclusion complexes were increased by 1.27-fold. 1.54-fold in pH 1.2 and 1.32-fold. 1.47-fold in pH 6.8 in comparison with that of AZT. The mean dissolution time (MDT, min) which represents the rapidity of dissolution rate of AZT, AZT-ACβCD. AZT-TAβCD were 5.12. 14.02 and 19.38 min in PH 1.2 and 2.52, 15.19 and 18.19 min in pH 6.8. AZT was very rapidly and completely dissolved in pH 1.2 and pH 6.8 within 5 minutes. But AZT-CD inclusion complexes showed the sustained release pattern in comparison with AZT alone. The simultaneous in situ nasal and jejunal recirculation study to compare the intrinsic absorptivity and the property of absorption sites revealed that the absorption of AZT-TAβCD (N:35.35±1.08% J:27.47±1.18% was more than that of AZT (N: 16.89±2.25%. J:15.86±2.33%. The above results suggest that TAβCD which is a hydrophobic cyclodextrin may serve as sustained release carrier with absorption enhancing effect.

시클로덱스트린과의 포접에 의한 케토고나졸의 비점막 흡수증가

박기배,이광표,노현구,안홍직,서보연,온윤성 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.2

Inclusion complexes of ketoconazole(KT) with α^-, β^- cyclodextrin(CD) and dimethyl-β-cyclodextrin (CD) and dimethyl-β-cyclodextrin(DMβCD) as nasal absorption enhancer were prepared in 1:2 molar ratios by freeze-drying and solvent evaporation methods. In order to compare with the intrinsic absorptivity of KT in the jejunum(J) and the nasal cavity(N), the in situ simultaneous perfusion method was employed. The in situ recirculation study revealed that KT-CD inclusion complexes with the greater stability constant and the faster dissolution rate proportionally increased the absorption of KT in the J and N of rats. The rank order of apparent KT permeability(P_(app) : ㎝/sec × 10^(-5)±S.E.), corrected by surface area of absorption, was 5.10±0.3(N, KT-DMβCD) >4.13±0.4(N, KT-β-CD) >3.52±0.2(N, KT-α-CD) >2.76±0.3(J, KT-DMβCD) >2.61±0.5(J, KT-β-CD) >2.42±0.4(J, KT-α-CD) at pH 4.0. The in crease in permeability of KT-DMβCD inclusion complex was 2.6 folds in the J and 4.5 folds in the N when the perfusing solution was changed from the buffer(pH 4.0) to saline. The absorption rate of KT-DMβCD inclusion complex after nasal administration was more rapid than those of ketoconazole alone and KT-DMβCD inclusion complex after oral administration to rats. In comparision with an oral administration of ketoconazole suspension in corn oil, the relative bioavailability was calculated 137.3% for the oral and 195.0% for nasal KT-DMβCD inclusion complex in rats. The present results suggest that KT-DMβCD inclusion complex may serve as a potential nasal absorption enhancer for the nasal delivery of ketoconazole.

이트라코나졸의 랫트 소장으로부터의 흡수

박기배,김영화,이용석,이광표 한국약제학회 1991 Journal of Pharmaceutical Investigation Vol.21 No.4

The absorption characteristics of itraconazole, which is an antifungal agent, from intestinal segments in the anesthetized rat in situ were investigated in order to design an effective oral drug delivery system. The pH-solubility profile of itraconazole, the rate and extent of absorption of itraconazole, the optimal absorption site(s) of itraconazole and the absorption enhancing effect of sodium cholate on itraconazole were examined in the present study. In situ single-pass perfusion method and recirculating perfusion technique using duodenum(D), jejunum(J) and ileum(I) were employed for the calculation of apparent permeability(Pe) and apparent first-order rate constant(Kobs), respectively. The results of this study were as follows: (1) Itraconazole showed appreciable aqueous solubility only at pH values of below 2.0. (2) pe(㎝/sec) decreased in the following order: D(10.24±1.78×10⁴)>J(8.86±0.79×10⁴)>I(3.78±0.13×10⁴). (3)Kobs(min⁴) decreased in the following order J(17.12±3.19×10³)>D(13.37±0.6×10⁴)>I(1.05±0.91×10³). (4) The solubility of itraconax makedlv increased with the increase of the concentration of sodium cholate. (5) The addition of 10 mM sodium cholate significantly mereased the apparent first-order rate constant of itraconazole in the ileum by a factor of 6.8.

테마제팜 연질캅셀제의 제조와 가토에 있에서 생체이용율

박기배,이광표,정의차,조정기 한국약제학회 1992 Journal of Pharmaceutical Investigation Vol.22 No.1

This study was carried out for the purpose of developing an effective temazepam soft elastic gelatin capsule (softgel) which exhibits an excellent bioavailability and of comparing the rate and extent of absorption of temazepam from the marked elixir and prepared softgel using hydrophilic liquid such as polyethylene glycol 400 as a suspending agent by rotary die method. Both softgel and elixir containing 3 mg of temazepam were given to 7 healthy male New Zealand White rabbits in a single oral dose cross-over study. Plasma temazepam concentrations were measured by HPLC. The mean peak concentrations of temazepam following a single oral dosing as softgel and elixir dosage form were 13.84 and 13.25 ng/㎖, respectively. And the mean time to peak concentration was 1.29 hr for the softgel and 1.07 hr for the elixir. There was no significant difference in the extent of drug absorption (AUC) for the two different dosage froms (p>0.05). While the softgel exhibited mean lag time of 0.63 hr, the elixir did not show any lag time. Statistical moment parameters such as the mean residence time and variance of the mean residence time did not differ significantly for the two formulations.

입자 크기에 따른 TiO₂산소센서의 감응효과

박기배,한상도,이상호,Hua, Yang,김명녕 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

Thick film type oxygen sensors based TiO_(2) doped with WO_(3)(5.0[wt%]) were investigated. TiO_(2) powders were sintered by sol-gel processing method in air atmosphere. Particle sizes of WO_(3) doped TiO_(2) prepared with conventional and nano crystal process were approximately 1[μm]~0.1[μm] and 20[nm] respectively. The sensor prepared with small size WO_(3)-TiO_(2) powders showed more enhanced oxygen sensing characteristics

Studies on Synthesis, Hydrolysis and Oral Absorption of Piperacillin Phthalidyl Ester

박기배,최승호,최영욱,김종갑,Park, Gee-Bae,Choi, Seung-Ho,Choi, Young-Wook,Kim, Johng-Kap 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.3

Piperacillin phthalidyl ester was synthesized by reacting piperacillin with triethylamine and bromophthalide in acetone and its chemical structure was determined by UV, IR, and PMR. The partition coefficient of the ester was increased and the ester was more lipophilic and less water soluble than piperacillin. The ester did not show the antimicrobial activity against Bacillus subtilis ATCC 6633 in vitro, but when hydrolyzed, the parent drug of ester, piperacillin, revealed antimicrobial activity in vivo. After a single oral dose of both piperacillin and the ester to rabbits, the serum piperacillin concentration was measured by bioassay. The ester exhibited improved pharmatokinetic characteristics: $T_{max}\;of\;2hr,\;C_{max}\;of\;4.26{\mu}g{\cdot}ml^{-1},K_{el}\;of\;0.057hr^{-1},\;and\;total\;AUC\;of\;85.42{\mu}g{\cdot}hr{\cdot}ml^{-1}$. Piperacillin on the other hand, did not exhibit any gastro-intestinal absorption.

임상약동학과 약물투여계획

朴基培 약사공론 1994 대한약사회지 Vol.1994 No.3

화염 진단 시스템 설계를 위한 기초 연구 (I)

박기배,이상호,김종원,진경태,손재익 경북대학교 센서기술연구소 1995 센서技術學術大會論文集 Vol.6 No.1

The objective of the project was the development of an optical approach which would indicate the presence of a flame and detect deviations from a desired set point. In this work, the flame quality indicator consisted of photodiode, optical fiber, interference filter and data acquisition system, and was tested in a lab-scale methane combustion system. It was needed to apply this system to pilot scale combustor in order to confirm whether temporal fluctuations might be correlated with important parameters of combustion process, such as fuel to air ratio and NO_(x) emissions or not.