측복부의 방추세포 지방종 치험 1례

최문섭,권호,정성노 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.1

Guinea pig에서 수종의 면역억제제 투여가 표피 Langerhans세포에 미치는 영향에 대한 연구

최문섭,홍창권,노병인,조사선,장진요 중앙대학교 의과대학 의과학연구소 1989 中央醫大誌 Vol.14 No.2

Langerhans cells (LC) are known to be immune macrophages of the epidermis and to play a crucial role as antigen presenting cells in the induction of positive immune responses to antigens presented through the skin. Because of their location in the epidermis, they are subject to many environmental toxins as well as epicutaneous medications. This study was undertaken to investigate the influence of topical and systemic administration of immunosuppressants on both Langerhans cells and their antigen presenting capacity in the Guinea pig. Hydrocortisone, prednisolone, cyclosporine A and azathioprine were administrated daily for 10 consecutive days by either topical application to skin, intraperitoneal injection or oral administration. LC densities were determined on the day following cessation of treatment by staining for the plasma membrane-bound ATPase in the EDTA-treated epidermal sheet preparation. DNFB-induced hypersensitivities were assayed by measuring the increment Of ear swelling. All immunosuppressants caused a significant reduction in ATPase-positive LC of the epidermis. Both topical application and systemic administration of immunosuppressants depleted the skin of LC, although topical treatment proved to be in a greater decrease in LC density than systemic administration. Furthermore, the decrease obtained in LC density correlated with substantial impairment in inducing hypersensitivity of the skin. The above finding suggested that immunosuppressants exert their inhibitory effect on contact hypersensitivity through suppression LC density and antigen-presenting function of these cells.

State-Space Poisson Models for Event-Count Time Series: Evidence from the Legislative Productivity of the U.S. Congress

최문섭,福元健太郞 한국경영과학회 2014 經營 科學 Vol.31 No.4

For event-count time series data, the Poisson distribution is limited because it assumes independent events. In this study, we horserace two state-space Poisson methods in analyzing the legislative productivity of the U.S. Congress:the Poisson exponentially weighted moving average (PEWMA) and Poisson autoregressive (PAR) models. They distinguish from the conventional Poisson and negative binomial event-count models by explicitly specifying the time-series process in a Bayesian parameter-feedback context. We find that (1) a divided government does not matter for the legislative productivity of the U.S. Congress; but, (2) electoral consideration of lawmakers urges them to make more laws in the election year, and (3) wider-seat margin Senatorial majority legislate more.

Home-made 요구르트와 시판 중인 요구르트에서 분리한 젖산균의 기능적 특성 조사

최문섭,윤현명,오계헌,Choi, Moon-Sup,Yun, Hyun-Myoung,Oh, Kye-Heon 한국미생물학회 2014 미생물학회지 Vol.50 No.1

본 연구는 home-made 요구르트에서 분리한 Lactobacillus casei SK-7과 시중에서 판매되고 있는 요구르트에서 분리한 Lactobacillus bulgaricus YK-11의 기능성을 비교 분석하기 위해 실시하였다. 먼저 분리세균인 SK-7과 YK-11의 생리화학적 특성조사를 진행하였다. 이들 균주는 16S rRNA 염기서열을 이용한 계통유전학적 분석방법으로 동정하여, 각각 L. casei SK-7와 L. bulgaricus YK-11로 명명하였다. 16S rRNA 염기서열을 바탕으로 SK-7과 YK-11의 유전적 계통수를 작성하였다. 72시간 동안 SK-7과 YK-11 배양에서 lactic acid와 acetic acid의 생산, 그리고 pH 변화를 조사하였다. 배양기간 동안 L. casei SK-7과 L. bulgaricus YK-11의 몇가지 기능성을 조사하였다. L. casei SK-7과 L. bulgaricus YK-11 배양상등액은 주어진 nitrite를 각각 93.9%와 88.2% 소거하였다. SK-7 and YK-11 배양상등액의 항산화능은 각각 62.6%와 54.9%였으며, ${\beta}$-galactosidase 활성은 14.9 units/mg과 13.1 units/mg로 측정되었다. 항미생물능력은 SK-7과 YK-11 배양의 20배 배양농축액으로 조사되었으며, SK-7은 이 조사에 사용된 모든 미생물에서 명백한 것으로 관찰되었으나, YK-11에서는 관찰되지 않았다. 부가적인 기능성 연구가 이루어져야 되겠지만, 본 연구에서는 home-made 요구르트에서 분리된 젖산균의 기능성은 시판요구르트에서의 기능성과 비교하여 우수한 것으로 조사되었다. The objective of this work is to investigate and compare several functional properties of lactic acid bacteria (LAB), Lactobacillus casei SK-7 isolated from home-made yogurt and Lactobacillus bulgaricus YK-11 from commercial yogurt. Initially, physiological and biochemical properties of SK-7 and YK-11 were characterized. Phylogenetic analysis using 16S rRNA sequencing were performed to identify the strains, and the strain could be assigned to Lactobacillus casei and Lactobacillus bulgaricus, designated as L. casei SK-7 and L. bulgaricus YK-11. Phylogenetic tree of SK-7 and YK-11 was plotted based on 16S rRNA sequence comparisons. Production of lactic acid and organic acid, and pH changes in the cultures of SK-7 and YK-11 were monitored during 72 h. During the incubation period, several functional properties of L. casei SK-7 and L. bulgaricus YK-11 were examined. L. casei SK-7 and L. bulgaricus YK-11 cultures eliminated 93.9% and 88.2% of nitrite, respectively. Antioxidant activity of cultural supernatants of SK-7 and YK-11 were 62.6%, 54.9%, and activity of ${\beta}$-galactosidase were 14.9 units/mg and 13.1 units/mg, respectively. The antimicrobial activities were examined with 20-fold concentrated culture supernatants from the cultures of SK-7 and YK-11. The activities of SK-7 supernatants were clearly observed against all microorganisms in this work, whereas no activities were observed in YK-11 supernatants. Although it might be conducted additional functional research, functional properties of LAB isolated from home-made yogurt have been shown to be better than those of commercial yogurt in this work.

발효된 물김치인 동치미에서 분리한 혼합 젖산균의 기능성 증진에 대한 연구

최문섭,김동민,오계헌 한국생물공학회 2015 KSBB Journal Vol.30 No.5

The aim of this work was to investigate the several functionalities of enhanced functionalities in cultures of single LAB (e.g., DK-3, DK-6, DK-13) and these three mixed LAB as probiotics isolated from Korean fermented watery Kimchi, Dongchimi. Both BIOLOG system and 16S rRNA sequencing were conducted to examine the characteristics and to identify the LAB strains, which were assigned to Leuconostoc mesenteroides DK-3, Leuconostoc dextranicum DK-6, and Lactobacillus curvatus DK-13, respectively. Phylogenetic analyses of the strains were plotted based on 16S rRNA sequence comparisons. Growth rate and pH changes during the growth, production of organic acids as metabolites, and as well as functional properties of the single and mixed LAB cultures were monitored and compared. In mixed LAB cultures after 72 h of incubation, maximum concentrations of lactic acid and acetic acid were approximately 340.5 mM and 191.9 mM, respectively, and pH was changed from 7.00 to 3.62. Mixed LAB cultures eliminated 96.3% of nitrite. Activities of antioxidant and β-galactosidase were 60.3% and 16.8 units/mg, respectively. Significant antibacterial activity of the concentrated supernatants was demonstrated against several foodpoisoning bacteria. Functionalities obtained from the mixed LAB cultures have been shown to be considerably higher than those of single LAB cultures. In consequence, these studies demonstrate that the all functionalities in mixed LAB cultures compared to the single cultures can be significantly enhanced

결막을 통한 바깥쪽 아래 눈꺼풀을 내리는 수술 (일명: 눈밑트임)

최문섭,김태형,황동연 대한미용성형외과학회 2012 Archives of Aesthetic Plastic Surgery Vol.18 No.1

Commonly, the lateral canthus is located higher than medial canthus and many people are often shown short lateral palpebral fissure. This seemed to be shown as wild, anxious, and pierced eye. Many surgeons have made desperate efforts to improve this by anchoring lateral canthus to lower part of orbital bone. But, authors would like to show the two-third portion of the lateral lower eyelid by anchoring to capsulopalpebral fascia via transconjunctival approach. Authors performed this operation since 2009 and first named it by “Nun-Mit-Teuim” in Korean. Key of this operation is that anchoring of the lower tarsus and capsulopalpebral fascia via transconjunctival approach without resection of skin. It is not necessary to remove a redundant conjunctiva. Commonly, the lateral canthoplasty is performed simultaneously to descend a lower eyelid easily. After the operation, it can be observed that the lower eyelid lift up a little bit for 1 2 weeks and redundant conjunctiva will be constricted in several months. The operation is defined as anchoring the lower tarsus to capsulopalpebral fascia. The limit of the operation is it cannot change the position of the lateral canthus. Over-lowering the lower eyelid to increase palpebral fissure, results in scleral show and unfavorable line. Thus, it is important that surgeons should remind the purpose and limitation of this operation.

외상의 흔적이 거의 없는 안와 파열골절

최문섭,조성필,변준희 大韓成形外科學會 2004 Archives of Plastic Surgery Vol.31 No.1

The Future Is Now: Evidence from Crude Oil Futures Trading

최문섭,Tina Xiaoxiao Liu 한국재무관리학회 2019 財務管理硏究 Vol.36 No.3

The global crude oil markets have gained fervent academic attention since Adelman’s (1984) claim of a “great pool”. Recently, the Shanghai International Energy Exchange became one of the largest trading venues in the world within less than a year since the listing of crude oil futures. In this research, using the frameworks of the vector autoregression and vector error correction models, we analyze the co-movement of crude oil futures prices among Shanghai crude, Brent crude, and West Texas Intermediate (WTI) crude. We find that Shanghai Granger-causes Brent and WTI, but not vice versa. Moreover, vector autoregression and vector error correction models imply that nearly half of Brent and WTI fluctuations originates from Shanghai and the influence peaks out on the fourth trading day following the initial shock. This research contributes to the literature as a documentation of China’s leadership in the price discovery of futures prices of crude oil fragmented across the world.

개인투자자 거래비의 대만 증시 우선주 할인율 결정에 한 연구

최문섭,최정화 한국재무관리학회 2018 財務管理硏究 Vol.35 No.4

The literature in corporate covernance dictates that the premium of common shares against their comparable preferred stocks is due to the voting right premium of commmon shareholders. Besides, recent studies find that the voting rights premium can vary across the borders due to the differences of legal origins and sovereign-level corporate governance. Furthermore, the time-series varions of common stock returns and preferred stock disounts in Korea are known to be determined by the individual trading weight that proxies for noise trader risk along with liquidity. This study finds that the discount of preferred shares listed on the Taiwan Stock Exchange is determined by the individual trading weight controlling for firm-level variables like the voting rights premium of common shareholders, the relative turnover of preferred shares, dividend per share or payout in the previous fiscal year, and for market-level variables like the market, size, value, and momentum strategy premium factors. This finding implies that noise trader risk exists in the Taiwan stock market and it is an important risk factor of asset returns there. 기업재무 문헌에서 보통주의 우선주 비 할증은 보통주주의 의결권에 의해 비롯됨이 알려져 있다. 아울러 최근 문헌상 연구에 따르면 법체계 국가수 지배구조의 차이에 따라 국가간 의결권리미엄의 차이가 날 수 있으며, 한국의 경우 개인투자자 비으로서 변되는 잡음거래자 험이 거래물량과 더불어 보통주 수익률 우선주의 보통주 비 할인율의 시계열 변화를 설명하는 것으로 알려져 있다. 본 연구는 만주식거래소에 상장된 우선주의 할인율을 결정하는데 있어 개인투자자 비이 통계유의인 험요인임을 보여다. 이 결과는 보통주주의 의결권리미엄, 우선주의 상 회율, 주당배당액 년도 배당여부 등의 기업 수 변수 Fama-French 4요인인 시장리미엄, 소형주 리미엄, 가치주리미엄 성략리미엄 등의 시장수 변수를 통제한 후에도 여히 유지된다. 이는 만 증시에 잡음거래자 험이 존재하며 자산 가격 결정에 요한 결정요인임을 함의한다.

산업폐수에서 농화한 미생물컨소시엄 CDIK-3에 의한 1,4-dioxane의 생분해에 영향을 미치는 물리화학적 요인

최문섭,최기승,오계헌 대한환경공학회 2020 대한환경공학회지 Vol.42 No.8

Objective:With the ultimate aim of application for effluent treatment, the relationships between 1,4-dioxane degradation by microbial consortium CDIK-3 and several relevant physicochemical environmental parameters were investigated. Methods:Microbial consortium CDIK-3 enriched from an industrial wastewater sample developed to grow aerobically with 1,4-dioxane as the sole carbon substrate was used to evaluate the degradation of 1,4-dioxane depending on the various environmental parameters and HPLC methodology was used to measure residual 1,4-dioxane in the test consortium. Results and Discussion:The microbial consortium, designated CDIK-3, was originally enriched from industrial wastewater sample. Complete depletion of 1,000 mg/L 1,4-dioxane was achieved in this experiment within 168 h. Effective 1,4-dioxane degradation was observed in slightly alkaline conditions (pH 8) and 30℃. The effect of supplemented carbon and nitrogen (e.g., glucose, yeast extract, ethylene glycol, tetrahydrofuran) on the 1,4-dioxane degradation by the CDIK-3 test culture was evaluated. The results indicated that the addition of glucose, yeast extract, or tetrahydrofuran accelerated bacterial growth compared to growth in the absence of supplemented carbons. In contrast, the addition of low concentrations (≤100 mg/L) of ethylene glycol accelerated 1,4-dioxane degradation, but the degradation of 1,4-dioxane was delayed in the culture to which high concentrations (≥200 mg/L) of ethylene glycol were added. Conclusions:1,4-Dioxane as a wastewater contaminant can be removed by the microbial consortium CDIK-3 enriched from industrial wastewater. Effective 1,4-dioxane removal was obtained by the control of various physicochemical parameters. These results provide clues for understanding improved 1,4-dioxane degradation by microbial consortium CDIK-3 with relevant environmental parameters and possible applications in the processing of industrial wastewater containing relatively high 1,4-dioxane concentrations. 목적:폐수처리에 적용하기 위한 궁극적인 목표를 가지고, 미생물컨소시엄 CDIK-3에 의한 1,4-dioxane 분해와 여러 가지 관련 물리화학적 환경요인들과의 관계를 조사하였다. 재료 및 방법:1,4-Dioxane을 유일한 탄소원으로 사용하여 호기적 조건에서 생장할 수 있는 미생물컨소시엄 CDIK-3를 산업폐수로부터 농화를 통해 확보하였다. 여러 가지 환경요인에 따른 1,4-dioxane의 분해를 평가하였으며, HPLC를 사용하여 1,4-dioxane의 농도를 측정하였다. 결과 및 토의:CDIK-3로 지정된 미생물컨소시엄은 원래 산업폐수로부터 농화되었다. 1,000 mg/L의 1,4-dioxane은 168시간 이내에 완전히 분해되었으며, 효율적인 1,4-dioxane 분해는 약알칼리성(pH 8)과 30℃에서 각각 관찰되었다. CDIK-3의 배양에서 1,4-dioxane 분해에 영향을 미치는 부가탄소원 및 질소원(예, glucose, yeast extract, ethylene glycol, tetrahydrofuran)의 효과를 조사하였다. 그 결과, glucose, yeast extract, 또는 tetrahydrofuran의 첨가는 부가탄소원을 첨가하지 않은 것과 비교하여, 1,4-dioxane의 분해를 향상되었다. 반면에 ethylene glycol은 저농도(≤100 mg/L)에서 1,4-dioxane 분해가 향상되었으나, 고농도(≥200 mg/L)가 첨가된 경우에는 1,4-dioxane 분해가 지연되었다. 결론:폐수오염물질인 1,4-dioxane은 산업폐수로부터 농화된 미생물컨소시엄 CDIK-3에 의해 제거될 수 있다. 다양한 물리화학적 요인의 조절을 통하여 효율적인 1,4-dioxane의 제거가 이루어졌다. 이러한 결과는 적절한 환경요인들 하에서 배양된 미생물컨소시엄 CDIK-3에 의해 1,4-dioxane 분해가 향상되는 것을 이해하는데 단서를 제공하며, 상대적으로 고농도의 1,4-dioxane을 포함하는 산업폐수의 처리에 적용될 수 있다.