Clinical Characteristics of Primary Thyroid Lymphoma in Koreans

HWANG, You-Cheol,KIM, Tae Yong,KIM, Won Bae,SHONG, Young Kee,YI, Ka Hee,SHONG, Minho,JO, Young Suk,KIM, Won Seog,CHUNG, Jae Hoon The Japan Endocrine Society 2009 Endocrine journal Vol.56 No.3

<P>Primary thyroid lymphoma is a very rare tumor and its prevalence is approximately 0.1% of all thyroid cancers in Korea. Its clinical experience is limited and not familiar to physicians. Therefore, we performed this study to investigate the clinical characteristics of primary thyroid lymphoma in Koreans. We retrospectively analyzed the medical records of the 44 patients with primary thyroid lymphoma from 1991 to 2006 at four major referral hospitals in Korea. Out of 44 patients, eight patients were male and 36 patients were female and their average age was 57 years. Fifty-six percent of patients had underlying Hashimoto′s thyroiditis. All but two patients had non-Hodgkin′s lymphoma with B cell origin, and eighty percent of patients presented with stage IE or IIE. Twenty-one of 44 patients (48%) had diffuse large B cell lymphoma (DLBCL) and 17 (39%) had MALT lymphoma. Malignancies originating from lymphoid cells were suspected in 10 of eighteen patients with DLBCL (56%) by using fine-needle aspiration cytology (FNAC), and no difference was noted compared with MALT lymphoma (64%). Compared with DLBCL, the patients with MALT lymphoma were more frequently presented with stage I disease (DLBCL vs. MALT lymphoma: 32% vs. 65%, P=0.04). Moreover, in contrast to DLBCL, most of the patients with MALT lymphoma achieved complete response with treatments (DLBCL vs. MALT lymphoma: 53% vs. 94%, P‹0.01). Because of the low diagnostic accuracy of FNAC, thyroid biopsy should be considered for the diagnosis of thyroid lymphomas in suspicious cases. The patients with MALT lymphoma were more frequently presented with early stage diseases and this might lead to the favorable outcome to treatments than those with DLBCL.</P>

Clinical Course of Patients with Ig A Nephropathy between Combined Treatment of Immunosuppressive Agents and ACE Inhibitor and ACE Inhibitor alone

(You Cheol Hwang),(Tae Won Lee),(Myung Jae Kim),(Moon Ho Yang),(Chun Gyoo Ihm) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.2

N/A Background : It has not been clear whether immunosuppressive therapy favorably influences renal function and proteinuria in IgA nephropathy (IgAN). Angiotensin converting enzyme inhibitor (ACEi) has an anti-proteinuric effect in IgAN. A retrospective study was done to see whether the addition of immunosuppressive therapy to ACEi produces a more excellent anti-proteinuric effect and preserves better renal function than ACEi alone. Methods : A total of 49 patients with proteinuria>1.0 g/day and serum creatinine concentrations<1.5 mg/dL were followed-up from at least 1 year to 9 years. Among them, 25 patients were treated with the combination of cyclophosphamide, prednisolone and ACEi while the other 24 were treated with ACEi alone. Results : The combination therapy or ACEi alone both reduced proteinuria with significant value (the combination group: from 5.74±5.08 to 2.29±2.77 g/day, ACEi group: from 3.85±2.54 to 1.68±1.91 g/day), while no significant differences in reduction of proteinuria were noticed between the two groups. There was no significant elevation of serum creatinine in both groups during follow-up (the combination group: from 0.91±0.20 to 1.03±0.38 mg/dL, ACEi group: from 0.93±0.27 to 0.99±0.37 mg/dL). This study showed no significant differences in the change in slope of 1/serum creatinine levels during the follow-up period between the two groups. Conclusion : We conclude that immunosuppressive therapy may not be beneficial in patients with proteinuric IgAN. ACEi may be a valuable therapeutic agent avoiding serious side effects of immunosuppressive agents.

Regulation of $I{\kappa}B$ Kinase by $G{\beta}L$ through Recruitment of the Protein Phosphatases

You, Dong-Joo,Kim, You-Lim,Park, Cho-Rong,Kim, Dong-Kyu,Yeom, Jeong-Hun,Lee, Cheol-Ju,Ahn, Curie,Seong, Jae-Young,Hwang, Jong-Ik Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.6

G protein ${\beta}$-like ($G{\beta}L$) is a member of WD repeat-containing family which are involved in various intracellular signaling events. In our previous report, we demonstrated that $G{\beta}L$ regulates TNF${\alpha}$-stimulated NF-${\kappa}$B signaling by interacting with and inhibiting phosphorylation of $I{\kappa}B$ kinase. However, $G{\beta}L$ itself does not seem to regulate IKK directly, because it contains no functional domains except WD domains. Here, using immunoprecipitation and proteomic analyses, we identified protein phosphatase 4 as a new binding partner of $G{\beta}L$. We also found that $G{\beta}L$ interacts with PP2A and PP6, other members of the same phosphatase family. By interacting with protein phosphatases, which do not directly bind to IKK${\beta}$, $G{\beta}L$ mediates the association of phosphatases with IKK${\beta}$. Overexpression of protein phosphatases inhibited TNF${\kappa}$-induced activation of NF-${\kappa}$B signaling, which is an effect similar to that of $G{\beta}L$ overexpression. Down-regulation of $G{\beta}L$ by small interfering RNA diminished the inhibitory effect of phosphatases, resulting in restoration of NF-${\kappa}$B signaling. Thus, we propose that $G{\beta}L$ functions as a negative regulator of NF-${\kappa}$B signaling by recruiting protein phosphatases to the IKK complex.

Neuro-Fuzzy Gust Front Detection Algorithm With S-Band Polarimetric Radar

Hwang, Yunsung,Yu, Tian-You,Lakshmanan, Valliappa,Kingfield, Darrel M.,Lee, Dong-In,You, Cheol-Hwan IEEE 2017 IEEE transactions on geoscience and remote sensing Vol.55 No.3

<P>A gust front (GF) is the leading edge of the cold outflow from a thunderstorm. The upgrade of the S-band Weather Surveillance Radar-1988 Doppler (WSR-88D) to dual-polarization has been completed recently in the U.S. Therefore, it is timely to exploit the added benefits of polarimetric variables to identify GFs. In this paper, six signatures derived from polarimetric WSR-88D data are developed to characterize GFs, including medium reflectivity, apparent thin line feature in reflectivity, and the motion of reflectivity quantified by a line feature parameter, high differential reflectivity, low copolar cross-correlation coefficient, apparent convergence manifested by the large radial shear, and large standard deviation of differential phase. These signatures are fuzzy in nature, and therefore, a novel neuro-fuzzy GF detection algorithm (NFGDA) is developed using a fuzzy logic inference system, which is optimized by a training process using a neural network. WSR-88D data from 11 cases (totaling 121 volume scans) are used to evaluate the performance of NFGDA and compared to the operational machine intelligent GF algorithm (MIGFA) with single polarization data. The results show that NFGDA can provide improved performance with a higher probability of detection of 92% (versus 78% with MIGFA), lower false alarm ratio of 0% (versus 9%), and higher percentage correct of 93% (versus 74%). Additional length-based scoring schemes show that NFGDA can correctly detect 62% (41% with MIGFA) of the total length of GFs, and minimize falsely detected length to 7% (61%).</P>

Association between Second-hand Smoke Exposure and Urinary NNAL Level in Korean Adolescents

You Hyo-Sun,Lee Jae-woo,Kim Ye-seul,Kim Yonghwan,Lee Hyeong-Cheol,Hwang Jin Young,Yang Woojung,Kang Hee-Taik 대한의학회 2021 Journal of Korean medical science Vol.36 No.13

Background: The 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a metabolite of tobacco-specific lung carcinogen that can be found in both smokers and non-smokers. Particularly, NNAL levels of children with a history of exposure to second-hand smoke (SHS) are higher than those of adults. Thus, we aimed to investigate the association between SHS exposure and urine NNAL levels in Korean adolescents. Methods: This cross-sectional study used data from the Korea National Health and Nutrition Examination Survey VII. Overall, 648 never-smoking adolescents (425 boys and 223 girls) aged 12 to 18 were included in this study. Logistic regression analyses identified the relationship between SHS exposure and elevated urine NNAL levels. Results: The mean urine NNAL levels of the no exposure and exposure group in boys were 1.39 and 2.26 ng/mL, respectively, whereas they were 1.01 and 2.45 ng/mL in girls, respectively (P < 0.001). Among the adolescents exposed to SHS, the confounder-adjusted odds ratio (95% confidence intervals) for elevated urine NNAL levels according to exposure area as overall, home, and public area were 2.68 (1.58–4.53), 31.02 (9.46–101.74), and 1.89 (1.12–3.17) in boys; and 6.50 (3.22–13.11), 20.09 (7.08–57.04), and 3.94 (1.98–7.77) in girls, respectively. Conclusion: SHS exposure was significantly associated with elevated urine NNAL levels in Korean adolescents, particularly in female adolescents and in those with home exposure. These findings remind us of the need to protect adolescents from SHS.

Toxicities of Difenoconazole on the Development of Xenopus laevis

You-Hwa Lee,Jong-Woo Hwang,Da-Ra Park,Jun-Cheol Lee,Seon-Woo Cheong 한국생명과학회 2008 한국생명과학회 심포지움 Vol.49 No.-

도로 낙석방지울타리의 낙석지지능력 평가

황영철(Hwang Young Cheol),유병옥(You Byung Ok),이승호(Lee Seung Ho) 대한토목학회 2002 대한토목학회 학술대회 Vol.2002 No.11

A fast Java Card Installer with the Resolution Using RAM

조유섭(You-Sub Cho),오세원(Se-Won Oh),이동욱(Dong-Wook Lee),황철준(Cheol-Jun Hwang),최원호(Won-Ho Choi),정민수(Min-Soo Jung) 한국멀티미디어학회 2006 한국멀티미디어학회 학술발표논문집 Vol.2006 No.2

Java Card makes it possible to easily have several applications and programs written in Java. The one of the main issues of Java Card is about memory optimization to maximize the use of limited smart card memory. In this paper, we propose a new JCVM Installer architecture. The key idea is to use RAM as much as possible by resolving indirect references in RAM, not EEPROM. It makes the Java Card more efficient in terms of speed during the post-issuance of applications. Writing in RAM is much faster than writing in EEPROM.

토사사면에서의 FRP보강 그라우팅 공법 적용성 평가

황영철(Hwang Young Cheol),김낙영(Kim Nak Young),유병옥(You Byung Ok),김성환(Kim Sung Hwan),최용기(Choi Yong Ki) 대한토목학회 2000 대한토목학회 학술발표회 논문집 Vol.2000 No.2

Cryopreservation with Trehalose Reduced Sperm Chromatin Damage in Miniature Pig

Park, Cheol-Ho,Kim, Sung-Won,Hwang, You-Jin,Kim, Dae-Young 韓國受精卵移植學會 2012 한국동물생명공학회지 Vol.27 No.2

Miniature pig sperm cryopreservation is continually researched in biotechnology for breed conservation and reproduction. It is important to control the temperature at each stage of cryopreservation and cryoprotectant. It is also necessary to find the optimal cryoprotectant concentration and chemical elements of the extender. Recently, many studies have used various cryoprotectant materials, such as dimethyl sulphoxide (DMSO), ethylene glycol (EG), antifreeze protein (AFP), amides, and glycerol. Glycerol is a commonly used cryoprotectant. However, glycerol has critical cytotoxic properties, including osmotic pressure and it can cause irreversible damage to live cells. Therefore, We focused on membrane fluidity modifications can reduce cell damage from freezing and thawing procedures and evaluated on the positive effects of trehalose to the viability, chromatin integrity, and motility of boar sperm. Miniature pig sperm was separated from semen by washing with modified- Modena B (mMB) extender. After centrifugation, the pellet was diluted with the prepared first extender. This experiment was designed to compare the effects that sperm cryopreservation using two different extenders has on sperm chromatin. The control group used the glycerol only and it was compared with the glycerol and glycerol plus trehalose extender. Sperm viability and motility were evaluated using WST1 assays and computer-assisted semen assays (CASA). Chromatin structure was examined using acridine orange staining. For the motility descriptors, trehalose caused a significant (p<0.01) increase in total motility ( in glycerol vs. in glycerol + trehalose) and progressive ( in glycerol vs. in glycerol + trehalose). A significant (p<0.05) increase in VAP ( vs. ), VSL ( vs. ), VCL ( vs. ), STR ( vs. ), and LIN ( vs. ) were also detected, respectively. The sperm DNA fragmentation index was 48.8% to glycerol only and 30.6% to glycerol plus trehalose. Trehalose added group showed higher percentages of sperm motility, stability of chromatin structure than glycerol only. In this study, we suggest that trehalose is effective in reducing freezing damage to miniature pig sperm and can reduce chromatin damage during cryopreservation.