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RISS 인기검색어
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- 저자 : (Wen Zhe Ho) (검색결과 1 건)
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Substance P 자극에 의한 대식세포의 TNF 분비
이혜란(Hae Ran lee),(Wen Zhe Ho),(Steven D . Douglas) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1993 소아알레르기 및 호흡기학회지 Vol.3 No.2
N/A Substance P (SP) is an undecapeptide of aminoacid sequence (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Gly-Leu-Met-NH2) that belongs to a family of structurally related peptides known as tachykinins and is widely distributed in the central nervous system SP is involved in biological activities of cells in the immune system including induction of cytokines in immune cells. We have investigated the effects of SP on constitutive and/or lipopolysaccharides (LPS)-induced expression of tumor necrosis factor (TNF) in cultured blood nonocyte-derived macrophages (MDM). Cells cultured in vitro for 14 days were treated with SP or SP fragments (SP1-4 and SP5-11) at various concentrations (10-10 to 10-6M) in the presence or absence of LPS before harvesting culture supernatants. TNF bioactivity in culture supernatants were measured with the L929 cell line. The MDM from ten of twelve donors showed significant production of TNF by the treatment of SP alone. SP and LPS also interact in a synergistic fashion in upregulating TNF production in MDM from responders. The stimulatory effect of SP was inhibited by two SP antagonists, spantide [D-Arg1,D-Trp7,9,Leu11]-SP and CP-96,345 (a non-peptide antagonist of the SP receptor). In addition, an anti-SP polyclonal antibody blocked the SP effect on the TNF production in the cultured MDM, further indicating the specificity of these effects. These results demonstrate that SP is an important regulator of monokine production in human monocytes/macrophages.
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