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Rehman, Shaheed Ur,Kim, n Sook,Choi, Min Sun,Luo, Zengwei,Yao, Guangming,Xue, Yongbo,Zhang, Yonghui,Yoo, Hye Hyun Korean Society for Mass Spectrometry 2015 Mass spectrometry letters Vol.6 No.2
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.
( Shaheed Ur Rehman ),( In Sook Kim ),( Min Sun Choi ),( Zengwei Luo ),( Guangming Yao ),( Yongbo Xue ),( Yonghui Zhang ),( Hye Hyun Yoo ) 한국질량분석학회 2015 Mass spectrometry letters Vol.6 No.2
Kinsenoside is a principle bioactive compound of Anoectochilus formosanus. It exhibits various pharmacological effects such as antihyperglycemic, antioxidant, anti-inflammatory, immunostimulating, and hepatoprotective activities and has recently been developed as an antidiabetic drug candidate. In this study, as part of an in vitro pharmacokinetic study, the stability of kinsenoside in rat and human liver microsomes was evaluated. Kinsenoside was found to have good metabolic stability in both rat and human liver microsomes. These results will provide useful information for further in vivo pharmacokinetic and metabolism studies.