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1
Epidermal Growth Factor Receptor Gene Amplification Predicts Worse Outcome in Patients With Surgically Resected Nonadenocarcinoma Lung Cancer

Chang, Hyun,Yang, Yaewon,Lee, Jong-Seok,Jheon, Sang-hoon,Kim, Yu Jung,Chung, Jin-Haeng Elsevier 2019 Clinical lung cancer Vol.20 No.1
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Abstract Purpose The aim of the present study was to examine the prognostic role of amplification and increased expression of the epidermal growth factor receptor (EGFR) gene in surgically resected non-adenocarcinoma of non-small cell lung cancer (NA-NSCLC). Materials and Methods The present retrospective study included 114 consecutive NA-NSCLC patients with available tumor tissue and survival data. EGFR gene copy number and protein expression were evaluated using fluorescent in situ hybridization (FISH) and immunohistochemistry in tissue microarray sections, respectively. Results Among 114 patients, 99 (86.8%) had squamous cell carcinoma histologic features. EGFR gene amplification and high polysomy (EGFR FISH+) were observed in 7.9% and 31.6% of cases, respectively. Patients with EGFR FISH+ had significantly shorter overall survival (P = .011). A multivariate model confirmed that patients with EGFR FISH+ had a significantly greater risk of death than EGFR FISH− patients after adjusting for pathologic stage, presence of pleural invasion, venous invasion, and surgical margins (hazard ratio, 1.36; 95% CI, 1.040 to 1.782; P = .025). EGFR protein expression by immunohistochemistry was not associated with overall survival in the same group. Neither EGFR gene amplification nor EGFR immunohistochemistry expression was associated with relapse-free survival. Conclusion An increased EGFR gene copy number in surgically resected NA-NSCLC was associated with worse survival.
2
Measuring Psychological Support for the Unemployed: The Case of Kakao NEET Project

( Jaekwan Jeong ),( Kahui Park ),( Yaewon Hyun ),( Daewon Kim ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.4
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  ScienceON
  
  KISS
This paper attempts to investigate Korean youth Not in Education, Employment and Training (NEET) and how daily activities and community participation may influence their positive emotions and job search desire. First, we conducted a focus group interview with 16 NEETs who participated in the Kakao NEET Company project. The project allowed participants to experience employment by founding a virtual company in which each participant selected a daily activity to perform as part of the company’s operations. Second, the interview responses were categorized and assigned emotional values using the card sorting technique and multi-dimensional analysis (MDS). A total of 11 emotional values were derived through this process. Finally, a social network analysis was conducted in order to measure the density of relations among the emotional values. Results suggest that immersion, confidence, belongingness were the three highest values evaluated by participants. Furthermore, network diagrams imply that the stronger participants perceived social support and belongingness with others, the stronger their responsibility grew, further leading them to establish steady goals. In particular, the high eigenvector score for “desire for job” suggests that emotional values are sequentially connected to the immersion-social support-responsibility-goal-job desire. This sequence suggests that digital services that are developed with the aim to enhance social values such as the Kakao NEET Project may engender motivation and confidence in youth NEETs. The overall results suggest that a systematic approach to policymaking should be considered in order to provide fundamental solutions and expand opportunities for social participation and emotional comfort, as social isolation due to low self-esteem has been reported as one of the reasons for NEETs’ failure in the labor market.
3
Feasibility and accessibility of electronic patient-reported outcome measures using a smartphone during routine chemotherapy: a pilot study

Bae, Woo Kyun,Kwon, Jihyun,Lee, Hyun Woo,Lee, Sang-Cheol,Song, Eun-Kee,Shim, Hyeok,Ryu, Keun Ho,Song, Jemin,Seo, Sungbo,Yang, Yaewon,Park, Jong-Hyock,Lee, Ki Hyeong,Han, Hye Sook Springer-Verlag 2018 SUPPORTIVE CARE IN CANCER Vol.26 No.11
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