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( Sun Young Huh ),( Jung Won Shin ),( Jung Im Na ),( Chang Hun Huh ),( Sang Woong Youn ),( Kyoung Chan Park ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.1
Background: Melasma is a common acquired symmetrical hypermelanosis that occurs on sun-exposed areas, and it is frequently observed among women. Various treatment modalities have been tried, but none are completely satisfactory. 4-n-butylresorcinol, which is a resorcinol derivative that has an inhibitory effect on both tyrosinase and tyrosinase-related protein-1, was introduced in 1995 and it has received increasing attention as a new hypopigmenting agent. However, the hypopigmenting effect of 4-n-butylresorcinol in human subjects has only been shown in a few studies. Objective: The aim of this study was to investigate the hypopigmenting efficacy and safety of 4-n-butylresorcinol 0.1% cream for the treatment of melasma. Methods: Twenty patients with melasma were enrolled to this randomized, double-blind, vehicle-controlled, split-face comparative study. The patients were instructed to apply 4-n-butylresorcinol 0.1% cream or vehicle to each side of the face twice daily for 8 weeks. Mexameter measurements were performed along with photography at baseline, 4 weeks and 8 weeks. Adverse events were observed and recorded throughout the study. Results: All the patients completed the study. Mexameter measurements demonstrated that the melanin index of the treated side showed a significant decrease when compared with that of the vehicle-treated side after 4 weeks (p=0.006) and after 8 weeks (p<0.0005). All the adverse reactions were mild and transient. Conclusion: 4-n-butylresorcinol 0.1% cream showed rapid efficacy and it was well tolerated when used for the treatment of melasma. (Ann Dermatol 22(1) 21∼25, 2010)
Park, Kyoung Sun,Lee, Ha-Young,Kim, Mi-Kyoung,Shin, Eun Ha,Jo, Seong Ho,Kim, Sang Doo,Im, Dong-Soon,Bae, Yoe-Sik American Society for Pharmacology and Experimental 2006 Molecular pharmacology Vol.69 No.3
<P>Lysophosphatidylserine (LPS) may be generated after phosphatidylserine-specific phospholipase A2 activation. However, the effects of LPS on cellular activities and the identities of its target molecules have not been fully elucidated. In this study, we observed that LPS stimulates an intracellular calcium increase in L2071 mouse fibroblast cells, and that this increase was inhibited by 1-[6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione (U-73122) but not by pertussis toxin, suggesting that LPS stimulates calcium signaling via G-protein coupled receptor-mediated phospholipase C activation. Moreover, LPS-induced calcium mobilization was not inhibited by the lysophosphatidic acid receptor antagonist, (S)-phosphoric acid mono-{2-octadec-9-enoylamino-3-[4-(pyridine-2-ylmethoxy)-phenyl]-propyl} ester (VPC 32183), thus indicating that LPS binds to a receptor other than lysophosphatidic acid receptors. It was also found that LPS stimulates two types of mitogen-activated protein kinase [i.e., extracellular signal-regulated protein kinase (ERK) and p38 kinase] in L2071 cells. Furthermore, these LPS-induced ERK and p38 kinase activations were inhibited by pertussis toxin, which suggests the role of pertussis toxin-sensitive G-proteins in the process. In terms of functional issues, LPS stimulated L2071 cell chemotactic migration, which was completely inhibited by pertussis toxin, indicating the involvement of pertussis toxin-sensitive G(i) protein(s). This chemotaxis of L2071 cells induced by LPS was also dramatically inhibited by 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002) and by 2'-amino-3'-methoxyflavone (PD98059). This study demonstrates that LPS stimulates at least two different signaling cascades, one of which involves a pertussis toxin-insensitive but phospholipase C-dependent intracellular calcium increase, and the other involves a pertussis toxin-sensitive chemotactic migration mediated by phosphoinositide 3-kinase and ERK.</P>
The Effect of Photodynamic Therapy Using Indole-3-Acetic Acid and Green Light on Acne Vulgaris
( Sun Young Huh ),( Jung Im Na ),( Chang Hun Huh ),( Kyoung Chan Park ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1
Background: Photodynamic therapy (PDT) using topical aminolevulinic acid (ALA) has increasingly been used for the treatment of acne vulgaris and several studies have shown its clinical efficacy. However, ALA-PDT needs a relatively long incubation period and is frequently associated with adverse effects. Indole-3-acetic acid (IAA) has been introduced as a new photosensitizer for the treatment of acne in recent study. IAA-PDT requires only a short incubation period and the procedure is relatively painless in contrast to ALA-PDT. Objective: To investigate the efficacy and safety of IAA- PDT in the treatment of acne. Methods: Twenty-five patients with facial acne lesions were enrolled in this study. IAA-PDT was performed for five sessions at 1-week intervals (week 0∼4). IAA was treated with 15 minute occlusion, and green light was given for 15 minutes. Clinical efficacy was determined by evaluating acne lesion counts, severity grading, and the Dermatology Life Quality Index (DLQI) at week 0, 2, 4, and 5. Sebum secretion and erythema index was measured by Sebumeter and Mexameter, respectively, at baseline and one week after each treatment session (week 1∼5). Histopathological examination was performed at baseline and week 5. Adverse effects were recorded throughout the study. Results: All the patients completed the study. Numbers of both inflammatory and non-inflammatory acne lesions were significantly decreased. Acne severity grade and the DLQI showed significant reduction. Sebum secretion and erythema were also reduced. Histopathological examination showed a reduction in inflammatory reactions. No adverse effects were observed except for transient pruritus in one patient. Conclusion: PDT using IAA and green light was an effective, simple and safe treatment for acne. (Ann Dermatol 24(1) 56∼60, 2012)
Survey for evaluating perceptions of workers in nursing homes regarding swallowing disorders
( Sun-young Yim ),( Ree-aie Ju ),( Hyo-jin Son ),( Inn-im Park ),( Yu-ri Heo ),( Mee-kyoung Son ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.3
This research is intended to be base data for suggestions about the role of dentists and new treatment methods for patients with swallowing disorders as a rehabilitation for oral functions under long-term care insurance for the elderly by investigating and evaluating the perception of the aged with dysphagia by the workers in nursing facilities. We analyzed 436 questionnaire surveys conducted on nursing facilities affiliated to the Association of Gwang-ju Welfare for the Aged through email from August 7, 2017, to September 8, 2017. Many workers in nursing facilities were concerned with the swallowing disorders among the patients, and the treatments they would request from the nursing-home dentists were dental check-ups, oral hygiene management, and eating-swallowing guidance and consultation. Our findings show that reconsideration of the role of the dentists is demanded, along with the awareness of nursing facility workers on swallowing disorders and the need for relevant treatments. Also, we must secure the institutional basis where the cooperation of the nursing and medical teams can take place.
Functional Identification of an 8-Oxoguanine Specific Endonuclease from Thermotoga maritima
Im, Eun-Kyoung,Hong, Chang-Hyung,Back, Jung-Ho,Han, Ye-Sun,Chung, Ji-Hyung Korean Society for Biochemistry and Molecular Biol 2005 Journal of biochemistry and molecular biology Vol.38 No.6
To date, no 8-oxoguanine-specific endonuclease-coding gene has been identified in Thermotoga maritima of the order Thermotogales, although its entire genome has been deciphered. However, the hypothetical protein Tm1821 from T. maritima, has a helix-hairpin-helix motif that is considered to be important for DNA binding and catalytic activity. Here, Tm1821 was overexpressed in Escherichia coli and purified using Ni-NTA affinity chromatography, protease digestion, and gel filtration. Tm1821 protein was found to efficiently cleave an oligonucleotide duplex containing 8-oxoguanine, but Tm1821 had little effect on other substrates containing modified bases. Moreover, Tm1821 strongly preferred DNA duplexes containing an 8-oxoguanine:C pair among oligonucleotide duplexes containing 8-oxoguanine paired with four different bases (A, C, G, or T). Furthermore, Tm1821 showed AP lyase activity and Schiff base formation with 8-oxoguanine in the presence of $NaBH_4$, which suggests that it is a bifunctional DNA glycosylase. Tm1821 protein shares unique conserved amino acids and substrate specificity with an 8-oxoguanine DNA glycosylase from the hyperthermophilic archaeon. Thus, the DNA recognition and catalytic mechanisms of Tm1821 protein are likely to be similar to archaeal repair protein, although T. maritima is an eubacterium.
Association of Rt. ventricular systolic function and conduction delay in patients with RBBB
( Sun Min Kim ),( Kyoung Im Cho ),( Sung Il Im ),( Hyun Su Kim ),( Jeong Ho Heo ),( Tae Joon Cha ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background: Elevated right ventricle (RV) pressure and/or volume can place stress on the right bundle branch block (RBBB) and its associated Purkinje network, which may affect its electrical properties resulting in conduction delay or block. We hypothesized that R′ wave duration in lead V1, prolonged laterportion of the QRS complex, would be an indicator of reduced RV function in patients with RBBB. Methods: The Kosin University echocardiography and electrocardiogram (ECG) database was reviewed from 2013 to 2014 to identify patients with complete RBBB. ECGs recorded closest to the time of the echocardiogram were carefully reviewed and measured QRS and R′ wave duration. RV systolic dysfunction was defined as RV fractional area change (FAC) <35%, as indicated by echocardiography guidelines. Results: Patients with RV dysfunction (n=241) showed more prolonged QRS duration (145.3±19.3 vs. 132.2±13.4 ms, p<0.001) predominantly due to R′ prolongation (84.8±13.0 vs. 102.9±12.0 ms, p<0.001) compared to the patients with normal RV function (n=123) (Table). R’duration was significantly associated with RV FAC (r=-0.609, p<0.001), as well as RV systolic pressure (r=0.142, p=0.008), RV dimension (r=0.193, p=≤0.001) and RV myocardial performance index (r=0.199, p<0.001) Conclusion: Prolonged R′ wave duration in lead V1would be an indicator of RV dysfunction as well as pressure and/or volume overload in patients with RBBB.
Prediction of Mean Corneal Power Change After Pterygium Excision
Kim, Sun Woong,Park, Saemi,Im, Chan Young,Seo, Kyoung Yul,Kim, Eung Kweon by Lippincott Williams Wilkins. 2014 Cornea Vol.33 No.2
PURPOSE:: The aim of this study was to predict the mean corneal power change preoperatively for simultaneous pterygium excision and cataract extraction. METHODS:: This study was performed in 2 stages. First, 66 eyes undergoing pterygium excision were recruited, and the subjects were divided into 2 groups based on a pterygium length of 2.0 mm (group 1: <2.0 mm, group 2: ≥2.0 mm). Keratometric values (K) were measured before, 1 month after, and 3 months after surgery. Multiple regression analyses were used to predict the postoperative mean K using preoperative K and morphological factors that significantly affect corneal power change. In the second stage, the regression equation was applied to 50 eyes (23 with pterygium <2.0 mm and 27 with pterygium ≥2.0 mm) in several clinics. Prediction accuracy was graded based on the difference between the calculated mean K and the postoperative mean K. RESULTS:: In group 1, the mean Ks did not change significantly after the surgery, and therefore, the predicted mean K was not statistically different from the preoperative mean K. In group 2, the horizontal and mean Ks steepened significantly, and the regression analysis predicted the mean K within the range of 0.5 diopter difference in 22 of 31 eyes, showing a better approximation compared with the preoperative mean K (P < 0.001). The prediction accuracy was verified similarly in other clinics, and the regression analysis was useful for pterygium exceeding a length of 2.0 mm. CONCLUSIONS:: Pterygium exceeding a length of 2.0 mm induced a significant corneal power change after surgery. The mean K predicted from the regression analysis could be used as an approximation for a simultaneous pterygium and cataract surgery.