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Yoo, Su Woong,Kim, Dong-Yeon,Lee, Changho,Min, Jung-Joon,Kwon, Seong Young Lippincott 2017 Clinical nuclear medicine Vol.42 No.12
ABSTRACT: Gastrointestinal tract is rarely a metastatic site of hepatocellular carcinoma (HCC). We present a 43-year-old woman with small bowel metastasis from HCC in which metastasis was detected using F-FDG PET/CT. However, the site of metastasis showed no significant uptake on C-acetate PET/CT. C-acetate PET/CT has a limited value in HCC patients with suspected extrahepatic metastasis, compared with F-FDG PET/CT.
Yoo, Su Woong,Kim, Jahae,Chong, Ari,Kwon, Seong-Young,Min, Jung-Joon,Song, Ho-Chun,Bom, Hee-Seung The Korea Society of Nuclear Medicine 2012 핵의학 분자영상 Vol.46 No.4
Purpose This study aimed to further stratify prognostic factors in patients with stage IV non-small cell lung cancer (NSCLC) by measuring their metabolic tumor volume (MTV) using F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT). Materials and Methods The subjects of this retrospective study were 57 patients with stage IV NSCLC. MTV, total lesion glycolysis (TLG), and maximum standardized uptake value (SUVmax) were measured on F-18 FDG PET/CT in both the primary lung lesion as well as metastatic lesions in torso. Optimal cutoff values of PET parameters were measured by receiver operating characteristic (ROC) curve analysis. Kaplan-Meier survival curves were used for evaluation of progression-free survival (PFS). The univariate and multivariate Cox proportional hazards models were used to select the significant prognostic factors. Results Univariate analysis showed that both MTV and TLG of primary lung lesion (MTV-lung and TLG-lung) were significant factors for prediction of PFS (P<0.001, P=0.038, respectively). Patients showing lower values of MTV-lung and TLG-lung than the cutoff values had significantly longer mean PFS than those with higher values. Hazard ratios (95 % confidence interval) of MTV-lung and TLG-lung measured by univariate analysis were 6.4 (2.5-16.3) and 2.4 (1.0-5.5), respectively. Multivariate analysis revealed that MTV-lung was the only significant factor for prediction of prognosis. Hazard ratio was 13.5 (1.6-111.1, P=0.016). Conclusion Patients with stage IV NSCLC could be further stratified into subgroups of significantly better and worse prognosis by MTVof primary lung lesion.
Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth
Yoo, Su Woong,Park, Hee-Jin,Oh, Gyungseok,Hwang, Soonjoo,Yun, Misun,Wang, Taejun,Seo, Young-Seok,Min, Jung-Joon,Kim, Ki Hean,Kim, Eung-Sam,Kim, Young L.,Chung, Euiheon Optical Society of Korea 2017 Current Optics and Photonics Vol.1 No.1
In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.
Woong-Shick Ahn,Su-Mi Bae,Sun-Young Kwak,Ae Ju Lee,Aery Lee,Yong Seok Lee,Il-Ju Bae,Jin-Young Yoo,Young-Joo Lee,김종국,Hong-Seok Chang 대한암예방학회 2006 Journal of cancer prevention Vol.11 No.1
As2O3 has been reported to be effective for treating acute leukemia and induce apoptosis in many tumor cells. In this study, we evaluated the ability of a novel arsenical compound, As4O6, along with As2O3 to induce cell growth inhibition as well as apoptosis in human cervical cancer cells, SiHa cells in vitro. To examine the levels of apoptosis, SiHa cells were given two sensitive doses, 0.5 and 1μM of arsenical compounds, and then, DNA fragmentation assay and FACS analysis were conducted. In addition, Western blotting assay was done for the identification of target molecules for apoptosis. Both As2O3 and As4O6 caused dose-dependent inhibition of SiHa cell proliferation. In particular, As4O6 was more effective for suppressing SiHa cell growth, as compared to As2O3. In parallel with inhibition of cell proliferation, As4O6 caused an increase of the sub-G1 cell population significantly more than As2O3, as determined by propidium iodide DNA staining. This was confirmed by DNA fragmentation assay and annexin V staining. Western blotting analysis also showed that the proliferating cell nuclear antigen (PCNA) expression was suppressed by As4O6 significantly more than As2O3, and that Bcl-XL with sequence homology to Bcl-2 was significantly suppressed by As4O6. However, apoptosis-related proteins, p21 and Bax, were expressed by As4O6 significantly more than As2O3. Taken together, these findings suggest that a novel arsenic compound, As4O6 possesses more potent anti-proliferative effects on human cervical cancer cells with induction of apoptosis at least through activation in p21 and Bax proteins in vitro. (Cancer Prev Res 11, 39-45, 2006)