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( Huiwu Luo ),( Fei Zhao ),( Shangfeng Chen ),( Huanzhang Lu ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.3
Bag of visual words is a popular model in human action recognition, but usually suffers from loss of spatial and temporal configuration information of local features, and large quantization error in its feature coding procedure. In this paper, to overcome the two deficiencies, we combine sparse coding with spatio-temporal pyramid for human action recognition, and regard this method as the baseline. More importantly, which is also the focus of this paper, we find that there is a hierarchical structure in feature vector constructed by the baseline method. To exploit the hierarchical structure information for better recognition accuracy, we propose a tree regularized classifier to convey the hierarchical structure information. The main contributions of this paper can be summarized as: first, we introduce a tree regularized classifier to encode the hierarchical structure information in feature vector for human action recognition. Second, we present an optimization algorithm to learn the parameters of the proposed classifier. Third, the performance of the proposed classifier is evaluated on YouTube, Hollywood2, and UCF50 datasets, the experimental results show that the proposed tree regularized classifier obtains better performance than SVM and other popular classifiers, and achieves promising results on the three datasets.
Qianqian Shan,Shengsheng Li,Qiyu Cao,Chenglong Yue,Mingshan Niu,Xiangyu Chen,Lin Shi,Huan Li,Shangfeng Gao,Jun Liang,Rutong Yu,Xuejiao Liu 대한생리학회-대한약리학회 2020 The Korean Journal of Physiology & Pharmacology Vol.24 No.3
Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.