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Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
( Su Hee Hong ),( Jee In Heo ),( Jeong Hyeon Kim ),( Sang Oh Kwon ),( Kyung Mok Yeo ),( Anna M Bakowska Barczak ),( Paul Kolodziejczyk ),( Ok Hyun Ryu ),( Moon Ki Cho ),( Young Hee Kang ),( Soon Sung 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.4
.Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed effi cient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.