Growth Hormone 1 T1663A Polymorphism, Recreational Physical Activity and BMI, and Breast Cancer Risk in Chinese Women

Gao, Chang-Ming,Ding, Jian-Hua,Wu, Jian-Shong,Cao, Hai-Xia,Li, Su-Ping,Liu, Yan-Ting,Tang, Jin-Hai,Tajima, Kazuo Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

To evaluate the relationship between the growth hormone 1 (GH1) T1663A polymorphism, recreational physical activity and body mass index (BMI) with reference to breast cancer, we conducted a case-control study with 669 cases of breast cancer and 682 population-based controls in Jiangsu Province, China. A structured questionnaire was used to elicit detailed information. All subjects completed an in-person interview. GH1 genotypes were identified using PCR-RFLP methods. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of GH1 genotypes was not significantly different between controls and cases ($x^2$=2.576, P=0.276). Results of stratified analysis by the participation status of the recreational physical activity showed that the persons with GH1 A allele were at a decreased risk of breast cancer (adjusted-OR=0.66; 95% CI, 0.50-0.87) only among inactive individuals. Stratified analysis by BMI showed that the genotype A/A was associated with a decreased risk of breast cancer only among individuals of the BMI <25 (adjusted-OR=0.80; 95% CI, 0.66-0.98). The findings of this study suggest that recreational physical activity and BMI may modify any association between the GH1 T1663A polymorphism and breast cancer risk.

Polymorphisms in XRCC1 Gene, Alcohol drinking, and Risk of Colorectal Cancer: a Case-control Study in Jiangsu Province of China

Gao, Chang-Ming,Ding, Jian-Hua,Li, Su-Ping,Liu, Yan-Ting,Cao, Hai-Xia,Wu, Jian-Zhong,Tang, Jin-Hai,Tajima, Kazuo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

To evaluate the relationship between alcohol drinking, XRCC1 codon 194 and 399 polymorphisms and risk of colorectal cancer, we conducted a case-control study with 315 colorectal cancer cases (105 colon, 210 rectal) and 439 population-based controls in Jiangsu Province of China. The XRCC1 codon 194 and 399 genotypes were identified using polymerase chain reaction and restrictrion fragment length polymorphism methods (PCR-RFLP). A structured questionnaire was used to elicit detailed information. Odds ratios (ORs) were estimated with an unconditional logistic model. In this study no significant differences were observed among the studied groups with regard to the genotype distribution of the XRCC1 codons 194 and 399 and the risk of colorectal cancer did not appear to be significantly influenced by genotype alone, whereas alcohol consumption showed a positive association (P for trend <0.01). When combined effects of XRCC1 polymorphisms and alcohol consumption were analyzed, we found that the 194Trp or 399Gln alleles further increased the colorectal cancer risk due to high alcohol intake. These findings support the conclusion that colorectal cancer susceptibility may be altered by gene-environment interactions.

Phenol removal via activated carbon from co-pyrolysis of waste coal tar pitch and vinasse

Ming Gao,Xiaona Wang,Changlei Xia,Na Song,Yuhui Ma,Qunhui Wang,Tianxue Yang,Shengbo Ge,Chuanfu Wu,Su Shiung Lam 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.1

The behavior and characteristics of phenol adsorption by activated carbon produced from co-pyrolysis of coal tar pitch and vinasse were investigated. Coal tar pitch and vinasse (mass ratio of 1 : 3) were firstly co-pyrolyzed and carbonated at 400 oC for 2 h. The carbonized material produced was then soaked with saturated KOH solution and activated at 800 oC for 1 h to form activated carbon. Results from the phenol wastewater adsorption experiments suggest that pseudo-second-order kinetics and the Weber-Morris model could reflect the time-dependent adsorption behavior of phenol wastewater by the activated carbon, revealing that internal diffusion represents the rate-limiting procedure and dominant process to control the adsorption rate in the early stage of the adsorption. Monolayer adsorption played the key role during the phenol adsorption. The adsorption was an endothermic reaction in temperature ranging from 15 oC to 35 oC, indicating that the adsorption speed could be stimulated by the increasing temperature. This study establishes a theoretical foundation for the usage and the potential application of the activated carbon derived from coal tar pitch and vinasse in wastewater treatment.

Serum Insulin-Like Growth Factor Binding Protein 7 for Esophagogastric Junction Adenocarcinoma Diagnosis

Gao-Ming Zhang,Guo-Ming Zhang,Jian-Hua Zhang 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4

Active and Passive Smoking, and Alcohol Drinking and Breast Cancer Risk in Chinese Women

Gao, Chang-Ming,Ding, Jian-Hua,Li, Su-Ping,Liu, Yan-Ting,Qian, Yun,Chang, Jun,Tang, Jin-Hai,Tajima, Kazuo Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

To evaluate the relation between smoking, alcohol drinking and risk of breast cancer in Chinese women, we conducted a case-control study with 669 cases and 682 population-based controls in Jiangsu Province of China. A structured questionnaire was used to elicit detailed information. Unconditional logistic regression analysis was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The results revealed that smoking, whether active or passive through the husband, was related to increased risk of breast cancer. The ORs (adjusted for age, menopausal status, educational levels, occupation, body mass index and income) were 3.55 (95%CI: 1.27-9.91) for active smoking and 1.47 (95%CI: 1.18-1.84) for passive smoking from husbands, respectively. A significant positive relationship was observed between breast cancer risk and the degree of husbands' smoking. There were significant increase trend in ORs with the daily smoked number of cigarettes of husbands, the passive smoking years from husbands and the pack-years of husbands' smoking (trend test: p=0.00003, 0.00013 and 0.0001, respectively). Alcohol consumption was also found to be a risk factor. The findings of this study in particular suggest that husbands' smoking increases risk of breast cancer in Chinese women.

가이디드 이미지 필터를 이용한 다중 스케일 분할 톤 매핑 기법

Ming Gao,정제창 한국방송∙미디어공학회 2018 방송공학회논문지 Vol.23 No.4

본 논문에서는 가이디드 이미지 필터를 이용한 다중 스케일 넓은 동적 영역 톤 매핑 알고리듬을 제안한다. 가이디드 이미지 필터는 이미지를 베이스 레이어와 디테일 레이어로 나누기 위해 사용된다. 이때 디테일 레이어의 동적 영역을 줄이기 위해 압축 함수가 사용된다. 하지만 대부분의 경우의 이미지는 다양한 스케일의 디테일과 에지 정보를 포함하고있다. 즉, 특정 스케일로 디테일 특성을 표현하는 것은 불가능하며 단일 스케일 이미지 분할 방법은 에지 주변에서 열화 현상을 야기시킨다. 이러한 문제를 해결하기 위해 다중 스케일 이미지 분할 방법을 제안한다. 다중 스케일의 디테일 레이어들을 이용하여 에지 보존 정도를 조절한다. 실험 결과를 통해 제안하는 알고리듬이 기존의 알고리듬 보다 에지 보존의 정도가 더 우수함을 보인다.

How Does Peer Feedback Training Work in EFL Writing?

( Ming Xia Gao ) 한국외국어대학교 외국어교육연구소 2014 외국어교육연구 Vol.28 No.2

Peer feedback, in which students work together in pairs or small groups to critique and provide comments on one another’s writing, is compatible with communicative approaches to second language acquisition (SLA) and process approaches to foreign language writing. This study, drawing on Vygotsky’s sociocultural learning theory, conducted a pretest -posttest comparison group quasi experimental design with multiple data being collected and analyzed quantitatively by using SPSSWID (ver. 17.0), to explore what role trained peer feedback plays in EFL writing context. Results of a series of t-tests in quantitative analysis showed that peer feedback training had positive effects on participants in various aspects. The experimental group students gained more than control group students in their posttest writing task. They outperformed the control group students in terms of comment quantity and quality, especially generating more specific and relevant comments on global issues and implementing more peer comments into their revisions. Peer feedback training also helped students cultivate more positive attitudes towards EFL writing. These findings suggest that peer feedback training has shown strong positive effects on EFL learners, that is, EFL students can perform peer feedback both efficiently and effectively as long as they are well-trained.

Polymorphisms in the Thymidylate Synthase Gene and Risk of Colorectal Cancer

Gao, Chang-Ming,Ding, Jian-Hua,Li, Su-Ping,Liu, Yan-Ting,Cao, Hai-Xia,Wu, Jian-Zhong,Tajima, Kazuo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

To evaluate the relationship between polymorphisms (28 bp repeated sequences in 5'-UTR and 6-bp ins/del in 3'-UTR) in then thymidylate synthetase gene (TS) and risk of colorectal, colon and rectal cancers, we conducted a case-control study with 315 cases of colorectal cancer and 439 population-based controls in Jiangsu province, China. TS genotypes were identified using PCR.RFLP (restriction fragment length polymorphism) methods. Odds ratios (ORs) were estimated with an unconditional logistic regression model. We found that the distributions of 5'-UTR genotypes in TS were significantly different between controls and male colon cases (${\chi}^2$=8.25, P = 0.016). Compared with 3R/3R genotype, individuals with the 2R allele were at an increased risk of colon cancer (age-, BMI-, smoking- and alcohol drinking-adjusted OR=1.98, 95%CI: 1.11-3.53) among men. In ccontrast, the 6-bp ins/del polymorphism at the TS 3'- UTR did not influence risk of the colorectal, colon and rectal cancers. When combined genotypes for both TS 5'-UTR and 3'-UTR polymorphisms were evaluated, individuals with the 5'-UTR 2R allele had a OR of 3.61 (95%CI: 1.38-9.49) for colon cancer among men with the 3'-UTR .6bp/-6bp genotype. These results show that the polymorphism of the 28 bp repeated sequences in TS 5'-UTR could influence susceptibility to colon cancer and that there was a coordinated effect between TS 3'-UTR and 5'-UTR polymorphisms in increasing risk of colon cancer among Chinese men.

Clinical Observation on Recombinant Human Endostatin Combined with Chemotherapy for Advanced Gastrointestinal Cancer

Gao, Shao-Rong,Li, Lu-Ming,Xia, Hai-Ping,Wang, Guang-Ming,Xu, Hong-Yan,Wang, Ai-Rong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Objective: To explore the clinical efficacy and toxic and side effects of recombinant human endostatin (rhendostatin/endostar) combined with chemotherapy in the treatment of advanced gastric cancer. Materials and Methods: A total of 70 patients with advanced gastrointestinal adenocarcioma confirmed by histopathology and/or cytological examination were divided into group A (37 patients) and group B (33 patients). Patients in group A were given intravenous drip of 15 mg endostar added into 500 mL normal saline, once every other day until the cessation of chemotherapy or patients' maximal tolerance to chemotherapy. Patients in group B received chemotherapy alone. Two groups selected the same chemotherapy regimens. FOLFIRI scheme: 90-min intravenous drip of $180mg/m^2$ irinotecan, intravenous drip of $200mg/m^2$ calcium folinate (CF) and $400mg/m^2$ 5-fluorouracil (5-Fu) on d1, and continuous intravenous pumping of 2 $400mg/m^2$ 5-Fu for 46 h. FOLFOX4 scheme: intravenous injection of $85mg/m^2$ oxaliplatin (L-OHP), $200mg/m^2$ calcium folinate (CF) and $400mg/m^2$ 5-FU on d1 for 2 h, and then continuous intravenous pumping of 2 $400mg/m^2$ 5-Fu for 46 h. XELOX scheme: oral administration of 1 $500mg/m^2$ xeloda (or tegafur 50~60 mg) in twice during d1~14 and intravenous drip of $135mg/m^2$ L-OHP on d1 for 2 h. The modified FOLFOX scheme: intravenous injection of $135mg/m^2$ L-OHP on d1 for 2 h, $200mg/m^2$ CF and 1.0 g tegafur during d1~5. Whereas, control Group B received chemotherapy regimens which were same as Group A, but no addition of endostar. Before chemotherapy, patients were given intravenous injection of 8 mg ondansetron, intramuscular injection of 10 mg metoclopramide and 20 mg diphenhydramine for prevention of vomiting, protection of liver and stomach as well as symptomatic supportive treatment. One cycle was 21 d, 4~6 cycles in total. The efficacy was evaluated every 2 cycles. Results: 32 patients in Group A could be evaluated, and the response rate (RR) and disease control rate (DCR) were 59.38% and 78.13%, respectively. 31 patients in Groups could be evaluated, and the RR and DCR were 32.26% and 54.84%, respectively. The differences between 2 groups were significant. The toxic effects include myelosuppression, gastrointestinal reaction, fatigue, cardiotoxicity and peripheral neurotoxicity. Conclusions: Preliminary observations show that endostar (once every other day) combined with chemotherapy is effective in the treatment of advanced gastrointestinal cancer, with low toxic effects, good tolerance, deserving further study.

Finite-time H∞ Adaptive Fault-Tolerant Control for Wing Flutter of Reentry Vehicle Subject to Input Saturation

Ming-Zhou Gao,Guo-Ping Cai 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.1

In current study for wing flutter of reentry vehicle, the effect of input saturation to wing flutter is rarelyconsidered and few of the fault-tolerant control problem is taken into account. In this paper, we use the radial basisfunction neural network and the finite-time adaptive fault-tolerant control technique to deal with the wing flutterproblem, which is subject to input saturation, parameter uncertainties and external disturbances. Sensor and actuatorfaults are both considered in the control design. Firstly, an optimal flight trajectory of reentry vehicle is designedusing the conjugate gradient method, so as to decrease the aerodynamic heating rate and temperature on the surfaceof the reentry vehicle. Then based on the trajectory optimization, we ignore the effect of temperature, and buildup the motion equation of wing flutter. Finally, a finite-time H¥ adaptive fault-tolerant controller is introduced. Simulation results indicate that, the optimized trajectory designed may decrease the aerodynamic heating rate ofthe reentry vehicle; the designed fault-tolerant controller can effectively deal with the faults in the system and canpromptly suppress the wing flutter as well.