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( Chijian Zhang ),( Yongjie Lu ),( Yong Ai ),( Xian Xu ),( Siyang Zhu ),( Bing Zhang ),( Minghui Tang ),( Lanyue Zhang ),( Tinggang He ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4
Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.
Current aspects of small extracellular vesicles in pain process and relief
Lanyu Zhang,Jin Liu,Cheng Zhou 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Small extracellular vesicles (sEVs) have been identified as a noteworthy paracrine mechanism of intercellular communication in diagnosing and managing neurological disorders. Current research suggests that sEVs play a pivotal role in the pathological progression of pain, emphasizing their critical function in the pathological progression of pain in acute and chronic pain models. By facilitating the transfer of diverse molecules, such as proteins, nucleic acids, and metabolites, sEVs can modulate pain signaling transmission in both the central and peripheral nervous systems. Furthermore, the unique molecules conveyed by sEVs in pain disorders indicate their potential as diagnostic biomarkers. The application of sEVs derived from mesenchymal stem cells (MSCs) in regenerative pain medicine has emerged as a promising strategy for pain management. Moreover, modified sEVs have garnered considerable attention in the investigation of pathological processes and therapeutic interventions. This review presents a comprehensive overview of the current knowledge regarding the involvement of sEVs in pain pathogenesis and treatment. Nevertheless, additional research is imperative to facilitate their clinical implementation.
Lingwei Tan,Jian Gao,Yuheng Luo,Lanyu Zhang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.5
The super-twisting algorithm (STA, a class of second-order sliding mode control (SOSMC)) is widely used in permanent magnet linear synchronous motor (PMLSM) systems for its least amount of information and simplest calculations among the SOSMC algorithms. Due to the discretization and sign function of the STA, the chattering problem may be induced. In this paper, we propose an STA method with a defined boundary layer (called δSTA) to further reduce chattering in high-precision positioning system. With the δSTA method, when the sliding variable crosses the zero point, the speed is adjusted via two different saturation functions, instead of discontinuous sign functions of the STA. The proposed control law was proven to be stable, ensuring the establishment of a second-order sliding mode. Both the simulation and experimental results showed that the proposed control scheme, with a defined boundary layer width, can improve the steady-state positioning accuracy and significantly reduce system chattering.