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RISS 인기검색어
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- 저자 : ( Kwangyong Na ) (검색결과 3 건)
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In Vitro Osteogenic Differentiation and Antibacterial Potentials of Chalcone Derivatives
Choi, Daheui,Park, Jin Chan,Lee, Ha Na,Moon, Ji-Hoi,Ahn, Hyo-won,Park, Kwangyong,Hong, Jinkee American Chemical Society 2018 Molecular pharmaceutics Vol.15 No.8
<P>Chalcone derivatives have been investigated as therapeutic agents for the anticancer, antioxidant, and anti-inflammatory fields. In this study, we have synthesized four different types of chalcone derivatives and demonstrated in vitro bioactivities. We divided these derivatives into two groups of chalcones on the basis of similar substituents on the aromatic rings, and we tested cell viability and proliferation potentials, which indicated that the methoxy substituent on the A ring could enhance cytotoxicity and antiproliferation potential depending on the chalcone concentration. We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist. In addition, chalcone bearing hydroxyl groups at the 2-, 4-, and 6-position on the A ring inhibited <I>treptococcus mutans</I> growth, a major causative agent of dental caries. Therefore, we concluded that the chalcone derivatives synthesized in this research can be good candidates for therapeutic agents promoting bone differentiation, with an expectation of inhibiting <I>S. mutans</I>, in dentistry.</P> [FIG OMISSION]</BR>
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( Tae Woong Kong ),( In Tae Kim ),( Tridib Kumar Sinha ),( Junho Moon ),( Dong Ho Kim ),( Inseon Kim ),( Kwangyong Na ),( Min-woo Kim ),( Hye-lin Kim ),( Taegyeong Hyeong ),( Jeong Seok Oh ) 한국고무학회 2020 엘라스토머 및 콤포지트 Vol.55 No.4
Stearic acid (SA), polyethylene glycol (PEG), and malic acid (MA) have been used to modify the surface of waste gypsum to develop corresponding poly (butylene adipate-co-terephthalate) (PBAT) composites. According to the mechanical properties, MA-treated gypsum (MA-gypsum) showed the best performance, whereas SA-gypsum showed the worst performance. In contrast to SA and PEG (having -COOH and -OH as polar functional groups, respectively), the presence of both -OH and -COOH in MA is responsible for the superior surface treatment of gypsum and its better dispersion in the polymer matrix (as revealed by FE-SEM analyses). The presence of long aliphatic chain in SA is supposed to inhibit the dispersion of SA-gypsum. Further, the performance of MA-gypsum/PBAT was enhanced by adding polylactic acid (PLA). The maximum optimized contents of MA-gypsum and PLA are 20 and 7.5 wt% for developing a high-performance PBAT composite.
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Comparing Waste Gypsum with CaCO₃ as Filler Towards Developing Low-cost PBAT C omposites
Tae Woong Kong(공태웅),In Tae Kim(김인태),Junho Moon(문준호),Tridib Kumar Sinha,Dong Ho Kim(김동호),Inseon Kim(김인선),Kwangyong Na(나광용),Kyum Woo Choi(최겸우),Jeong Seok Oh(오정석) 한국고분자학회 2021 폴리머 Vol.45 No.1
폐석고(CaSO₄) 및 탄산칼슘(CaCO₃)을 이용하여 poly(butylene adipate-co-terephthalate)(PBAT) 복합체를 용융혼합으로 제조한 뒤 비교하였다. 석고와 탄산칼슘은 Ca<SUP>2+</SUP> 양이온을 동일하게 포함하지만 다른 크기의 음이온 즉, 각각 SO₄<SUP>2-</SUP>, CO₃<SUP>2-</SUP>을 함유하고 있다. Fajans’ rule에 따르면 CaCO₃는 이온성이 더 큰 반면, CaSO₄는 편극성이 더 크다. 석고는 탄산칼슘에 비해 편극성이 크기 때문에 filler-matrix간 정전기적 상호작용에 의해 PBAT 내에 분산이 더 잘 되었다. 석고/PBAT 복합체는 충전제-고분자 함량 20:80의 비율에서 탄산칼슘/PBAT 복합체 대비 낮은 인장강도와 높은 연신율 값을 나타냈다. Polylactic acid(PLA)를 첨가함에 따라 석고/PLA/PBAT 복합체는 인장강도와 연신율이 향상했지만 탄산칼슘/PLA/PBAT 복합체의 경우에는 PLA의 첨가에 따른 효과가 관찰되지 않았다. 이는 탄산칼슘에 의한 PLA의 depolymerization에 기인하는 것으로 사료된다. 이러한 복합체의 기계적 거동은 열적, 형태학적, 결정학적 분석을 통해 잘 설명되었다. Melt-mixed composites of poly(butylene adipate-co-terephthalate) (PBAT) with the waste gypsum and calcium carbonate were prepared and their properties were compared. Calcium carbonate and gypsum contain the same cation (Ca<SUP>2+</SUP>) but different anions i.e., smaller CO₃<SUP>2-</SUP> and larger SO₄<SUP>2-</SUP> respectively. According to the Fajans’ rule, CaCO₃ is more ionic whereas gypsum is more polarizable. Because of the abundant polarizability, gypsum was well dispersed in the PBAT matrix through the filler-matrix electrostatic interaction. The gypsum/PBAT showed lower tensile strength but higher elongation at break at a filler to matrix ratio of 20: 80 than those of CaCO₃/PBAT. Further, the addition of polylactic acid (PLA) enhanced both the tensile strength and elongation at break of the gypsum/PLA/PBAT while no such effective changes were observed for CaCO₃/PLA/PBAT maybe due to the possibility of depolymerization of polymers in the presence CaCO₃. Thermal, morphological, and crystallography studies well corroborate with the mechanical behavior of the composites.
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