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Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2
Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.
Helicobacter pyloir 양성 소화성 궤양에서 lansoprazole 포함 삼제요법의 제균율 및 제균판정에 있어서 요소호기검사의 유용성
정혜경,곽재진,유민아,배기선,권정미,이종수,김도영,문일환 대한감염학회 2003 감염과 화학요법 Vol.35 No.3
목적 : 본 연구는 Helicobacter pylori (이하 H. polyri) 양성인 소화성 궤양 환자에서 lansoprazole 포함 삼제요법의 제균율을 알아보고, 제균 치료 후 제균 판정에 있어서 요소 호기 검사(Urea breath test, 이하 UBT) 및 신속요소분해(rapid urease test, 이하 RUT test)와의 일치율에 대하여 알아보고자 하였다. 방법 : 상부위장관내시경 검사에서 H. polyri 양성인 소화성 궤양환자에서 lansoprazole 60㎎+amoxicillin 2g+clarithromycin 1g의 약제를 2회 분복하여 1주간 복용하는 삼제요법을 실시하였다. 최소 4주후 추적 상부위장관내시경을 실시하였고, 전정부와 체부에서 각각 RUT를 실시하였으며 UBT(5분, 20분)를 시행하였다. 결과 : 대상환자는 총 46명으로 남자 34명(48±13세), 여자 12명(53±14세)이었다. LAC 삼제요법의 제균율은 40/46명(87.0%)이었고, 궤양의 치유율도 42/46명(91.3%)이었다. RUT와 20분 UBT 결과가 모두 음성이었던 경우는 41예, 모두 양성이었던 경우는 4예로 RUT와 UBT는 97.8% (45/46)의 일치율을 보였고, 1예는 UBT는 음성이었으나 체부에서 시행한 RUT가 양성이었다. 5분 UBT 검사가 양성이었던 예는 14/34 (41.2%) 이었고, 이 14예 중 12예(85.7%)는 20분 UBT 검사 음성, RUT 음성이었다. 결론 : Lansoprazole과 amoxicillin, clarithromycin 1주일 병합요법은 H. polyri 양성인 소화성 궤양 환자에서 87.0%의 제균율을 나타내어 우수한 효과를 보였고, 요소호기검사는 제균 치료 후 제균 판정에 유용한 비침습적인 방법임을 확인할 수 있었다. Background : There are only a few studies on Helicobacter pylori (H. pylori) for its eradication rates of lansoprazole-based triple therapy in Korea, and the results are controversial. Therefore, we undertook to investigate the eradication rate of lansoprazole-based triple therapy, and compare the concordance rate of urea breath test (UBT) and rapid urease test (RUT) in evaluating H. pylori eradication. Methods : Patients with acute peptic ulcer who were H. pylori-positive were recruited by prospective, consecutive manner. They received lansoprazole 30 ㎎ b.d., amoxicillin 1 g b.d. and clarithromycin 500 ㎎ b.d. for 1 week. Upper endoscopy was performed after 4 weeks to check for ulcer healing, and UBT and RUT were performed to evaluate H. pylori eradication status. Results : A total of 46 patients were recruited, and they were all compliant. H. pylori eradication rate was 87.0% (40/46) and ulcer healing rate was 91.3% (42/46). Forty one patients showed negative in both UBT and RUT, and 4 patients revealed positive in both tests, therefore, the concordance rate of UBT and RUT was 97.8% (45/46). Conclusion : Our study showed that 1-week lansoprazole-based triple therapy was effective in H. pylori eradication and ulcer healing. UBT can be an effective, noninvasive method for evaluating H. pylori status after H. pylori eradication.
국내외 ‘영아’ 관련 연구물의 최근 동향 분석 : 2000년~2013년 발간 논문을 대상으로
이승연,권수현,권연정,김언경,나영이,유주연,최정아 이화여자대학교 교육과학연구소 2015 교육과학연구 Vol.46 No.3
The purpose of this study was to examine research trends in infant research published from 2000 to 2013, in order to understand overall aspects in research topics, methods, and subjects in infant research and to suggest directions for future infant research. A total of 2916 journal articles and theses/dissertations, both domestic and foreign, were selected for the analysis. The findings of this study were as follows: First, for the 14 year period, 737 domestic articles, 634 domestic theses/ dissertations, 1242 foreign articles, and 303 foreign dissertations on infant research were published, and there was a steady increase in the number of articles and theses/dissertations over the years. Second, in terms of research topics, different patterns were found between the domestic ones and the foreign ones; the topic of “education and teachers” in the domestic ones and “development” in the foreign ones occurred most frequently. Third, in terms of research methods, the domestic ones employed “survey” the most, and the foreign ones employed “experiment” the most among quantitative research methods; when analyzing the relation between methods and topics, the foreign ones showed clear matches between topics and research methods, while the domestic ones preferred “survey” regardless of the topics. Fourth, in terms of subjects/participants, “infants” were the most researched in both the domestic ones and the foreign ones, followed by “parent” and “teachers.” Among the infants, the domestic ones focused on 25~36-month olds the most, while the foreign ones focused most on 0~12-month olds. In addition, in all types of infant research, there were more single subject studies than multiple subject ones.
Jung, Jin Ah,Kim, Tae-Eun,Lee, Hyun,Jeong, Byeong-Ho,Park, Hye Yun,Jeon, Kyeongman,Kwon, O Jung,Ko, Jae-Wook,Choi, Rihwa,Woo, Hye-In,Koh, Won-Jung,Lee, Soo-Youn Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P><B>Background/aim</B></P><P>Isoniazid (INH) is an essential component of first-line anti-tuberculosis (TB) treatment. However, treatment with INH is complicated by polymorphisms in the expression of the enzyme system primarily responsible for its elimination, N-acetyltransferase 2 (NAT2), and its associated hepatotoxicity. The objective of this study was to develop an individualized INH dosing regimen using a pharmacogenetic-driven model and to apply this regimen in a pilot study.</P><P><B>Methods</B></P><P>A total of 206 patients with TB who received anti-TB treatment were included in this prospective study. The 2-hour post-dose concentrations of INH were obtained, and their <I>NAT2</I> genotype was determined using polymerase chain reaction and sequencing. A multivariate regression analysis that included the variables of age, sex, body weight, and <I>NAT2</I> genotype was performed to determine the best model for estimating the INH dose that achieves a concentration of 3.0–6.0 mg/L. This dosing algorithm was then used for newly enrolled 53 patients.</P><P><B>Results</B></P><P>Serum concentrations of INH were significantly lower in the rapid-acetylators than in the slow-acetylators (2.55 mg/L vs 6.78 mg/L, median, <I>P</I><0.001). A multivariate stepwise linear regression analysis revealed that NAT2 and body weight independently affected INH concentrations: INH concentration (mg/L) =13.821–0.1× (body weight, kg) −2.273× (number of high activity alleles of <I>NAT2</I>; 0, 1, 2). In 53 newly enrolled patients, the frequency at which they were within the therapeutic range of 3.0–6.0 mg/L was higher in the model-based treatment group compared to the standard treatment group (80.8% vs 59.3%).</P><P><B>Conclusion</B></P><P>The use of individualized pharmacogenetic-guided INH dosage regimens that incorporate <I>NAT2</I> genotype and body weight may help to ensure achievement of therapeutic concentrations of INH in the TB patients.</P>
Jung Jae-Kyung,Jung Eun-Kyung,Kwon Nam-Goong,Cho Jung-Sook,Kim Hwan-Mook,Park Sung-Gyu,Yoo Yeong-Ah,Kwon Joo-Hee,Lee Hee-Soon The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.4
A series of 8-alkyl-and 8-aryl-8,9-dihydro-7H-isoindolo[5,6-g]quinoxaline-7,9-diones were synthesized using sultine chemistry as a key step in good yield. These compounds were evaluated for their in vitro cytotoxicity against six human cancer cell lines (HCT15, SK-OV-3, A549, SNB19, MCF7 and MCF7/ADR).
[PC-0021] Construction of Deep Learning-Based Disease Detection Model in Plants
Minah Jung(Minah Jung),Jong Seob Song(Jong Seob Song),Ah-Young Shin(Ah-Young Shin),Beomjo Choi(Beomjo Choi),Sangjin Go(Sangjin Go),Suk-Yoon Kwon(Suk-Yoon Kwon),Juhan Park(Juhan Park),Sung Goo Park(Sun 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Hyeon-Ah Lee,Yeon Jung Lee,Kyong Ah Kim,Myungjae Baik,Jong-Woo Paik,Jinmi Seol,Sang Min Lee,Eun-Jin Lee,Haewoo Lee,Meerae Lim,Jin Yong Jun,Seon Wan Ki,Hong Jin Jeon,Sun Jung Kwon,Hwa-Young Lee 대한신경정신의학회 2024 PSYCHIATRY INVESTIGATION Vol.21 No.8
Objective The increasing concern over adolescent suicide necessitates suicide prevention training for school teachers, as students spend a significant portion of their time at school. This study’s objective is to develop a suicide prevention program tailored for teachers. Methods The program was developed by a multidisciplinary research team, drawing on a review of both domestic and international sui-cide prevention programs, related scholarly articles, and Korean psychological autopsy interviews of adolescents. This was complemented by a survey of teachers to assess the program’s practicality and usability. Results The developed program comprises three parts, consistent with other versions: Careful Observation, Active Listening, and Risk Evaluation and Expert Referral. Careful Observation focuses on training teachers to recognize verbal, behavioral, and situational warn-ing signs of suicidal ideation in students; Active Listening involves strategies for encouraging students to express their suicidal thoughts and techniques for being an empathetic and attentive listener; Risk Evaluation and Expert Referral provides instruction on how to assess suicide risk and assist students safely. Conclusion It is anticipated that this program will equip teachers with valuable knowledge and skills, contributing to a reduction in ado-lescents suicide rates.