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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
Hirsutenone Directly Blocks Human <i>ether-a-go-go</i> Related Gene K<sup>+</sup> Channels
Yun, Jihyun,Bae, Hyemi,Choi, Sun Eun,Kim, Jung-Ha,Choi, Young Wook,Lim, Inja,Lee, Chung Soo,Lee, Min Won,Ko, Jae-Hong,Seo, Seong Jun,Bang, Hyoweon Pharmaceutical Society of Japan 2011 Biological & pharmaceutical bulletin Vol.34 No.12
<P>The aim of the present study was to investigate whether hirsutenone affects the human <I>ether-a-go-go</I> related gene (hERG) K<SUP>+</SUP> channels. Many drugs promote formation of the acquired form of long QT syndrome (LQTS) by blocking the hERG K<SUP>+</SUP> channels. Hirsutenone, a new candidate for the treatment inflammatory skin lesions, induced a concentration-dependent decrease in hERG K<SUP>+</SUP> current amplitudes. Hirsutenone significantly decreased the time constants at the onset of inactivation. However, the reductions in the time constants of steady-state inactivation and the recovery from inactivation after hirsutenone treatment were not significant. In addition, the drug had no effect on the voltage-dependent activation curve or the steady-state inactivation curve. In summary, hirsutenone potentially acts as a blocker of hERG K<SUP>+</SUP> channels functioning by modifying the channel inactivation kinetics.</P>
A Switching Technique for Common Mode Voltage Reduction of 2-Level Inverter
Yun Hwan-Kyun,Kim Lee-Hun,Kim Jun-Ho,Won Chung-Yuen,Choi Gi-Su,Bae Joung-Hwan 전력전자학회 2001 ICPE(ISPE)논문집 Vol.2001 No.10
Much attention has given to EMI effects created by variable speed ac drive system This paper focuses on the switching technique to mitigate common mode voltage<br/> Zero switching states of inverter control invoke large common mode voltage Using inversed carrier wave, zero switching states are removed In addition, proposed technique is easy to apply to existing 2-level inverter design. And common mode mitigation technique for sinusoidal PWM is also presented<br/> Proposed switching technique is implemented with a 2 2kw 1735rpm induction motor<br/> Index Terms-Conducted emissions, drives, electromagnetic compatibility.<br/>
Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene $K^+$ Channels
Yun, Jihyun,Bae, Hyemi,Choi, Sun Eun,Kim, Jung-Ha,Choi, Young Wook,Lim, Inja,Lee, Chung Soo,Lee, Min Won,Ko, Jae-Hong,Seo, Seong Jun,Bang, Hyoweon The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.1
Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) $K^+$ channels. To determine whether taxifolin glycoside would block hERG $K^+$ channels, we recorded hERG $K^+$ currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG $K^+$ current in a concentration-dependent manner ($EC_{50}=9.6{\pm}0.7{\mu}M$). The activation curve of hERG $K^+$ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG $K^+$ channels that function by facilitating activation and inactivation process.
Yun, Jieun,Han, Sang-Bae,Kim, Hong Jun,Go, Se-il,Lee, Won Sup,Bae, Woo Kyun,Cho, Sang-Hee,Song, Eun-Kee,Lee, Ok-Jun,Kim, Hee Kyung,Yang, Yaewon,Kwon, Jihyun,Chae, Hee Bok,Lee, Ki Hyeong,Han, Hye Sook The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.3
Purpose: Peritoneal carcinomatosis in gastric cancer (GC) patients results in extremely poor prognosis. Malignant ascites samples are the most appropriate biological material to use to evaluate biomarkers for peritoneal carcinomatosis. This study identified exosomal MicroRNAs (miRNAs) differently expressed between benign liver cirrhosis-associated ascites (LC-ascites) and malignant gastric cancer-associated ascites (GC-ascites), and validated their role as diagnostic biomarkers for GC-ascites. Materials and Methods: Total RNA was extracted from exosomes isolated from 165 ascites samples (73 LC-ascites and 92 GC-ascites). Initially, microarrays were used to screen the expression levels of 2,006 miRNAs in the discovery cohort (n=22). Subsequently, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) analyses were performed to validate the expression levels of selected exosomal miRNAs in the training (n=70) and validation (n=73) cohorts. Furthermore, carcinoembryonic antigen (CEA) levels were determined in ascites samples. Results: The miR-574-3p, miR-181b-5p, miR-4481, and miR-181d were significantly downregulated in the GC-ascites samples compared to the LC-ascites samples, and miR-181b-5p showed the best diagnostic performance for GC-ascites (area under the curve [AUC]=0.798 and 0.846 for the training and validation cohorts, respectively). The diagnostic performance of CEA for GC-ascites was improved by the combined analysis of miR-181b-5p and CEA (AUC=0.981 and 0.946 for the training and validation cohorts, respectively). Conclusions: We identified exosomal miRNAs capable of distinguishing between non-malignant and GC-ascites, showing that the combined use of miR-181b-5p and CEA could improve diagnosis.
Jun Young Kim,Mira Yun,Du-Won Jeong,Ju-Jin Kim,I. J. Lee 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.1
The free-standing single crystal tetramethyltetraselenafulvalene (TMTSF) has been grown with physical vapor deposition (PVD) technique. X-ray diffraction (XRD) analysis shows that both the metallic (TMTSF)2PF6 and the semiconducting TMTSF have a triclinic crystal structure with a P-1 space group. The TMTSF single crystal forms a brick wall like stacking structure within the ac-plane, which reduces the overall anisotropy of the system. The intrinsic electrical transport properties of the semiconducting TMTSF were probed, utilizing a polymer-based field effect transistor. The TMTSF organic semiconductor exhibited a typical p-type semiconducting characteristics. The field effect mobility was obtained as 3.96 cm2/Vs, which is an order of magnitude higher than the value reported previously for single crystal TMTSF. The free-standing single crystal tetramethyltetraselenafulvalene (TMTSF) has been grown with physical vapor deposition (PVD) technique. X-ray diffraction (XRD) analysis shows that both the metallic (TMTSF)2PF6 and the semiconducting TMTSF have a triclinic crystal structure with a P-1 space group. The TMTSF single crystal forms a brick wall like stacking structure within the ac-plane, which reduces the overall anisotropy of the system. The intrinsic electrical transport properties of the semiconducting TMTSF were probed, utilizing a polymer-based field effect transistor. The TMTSF organic semiconductor exhibited a typical p-type semiconducting characteristics. The field effect mobility was obtained as 3.96 cm2/Vs, which is an order of magnitude higher than the value reported previously for single crystal TMTSF.