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TBT의 노출에 따른 넙치, Paralichthys olivaceus의 생존, 성장 및 산소소비의 변화
강주찬,황운기,지정훈 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.3
This study was carried out to examine the effects of his (tribytyltin)oxide (TBT), endocrine disrupting compounds (EDCs), on the changes of survival, growth and oxygen consumption rate in the oliver flounder, Paralichthys olivaceus. Oliver Flounders were exposed to sublethal concentration of TBT (0, 1.67, 3.20, 6.30 and 12.50㎍/L) during 6 weeks. Survival rate was decreased in a concentration and exposure period-dependent way and suddenly the reduction of more than 20% occurred at TBT concentration greater than 3.20㎍/L after exposure 6 weeks. Growth rate and feed efficiency significantly decreased at concentration greater than 3.20㎍/L. Oxygen consumption rate was also decreased in a concentration-dependent way and significantly decreased to 17, 48 and 67% than that of the control at the TBT concentration of 3.20, 6.32 and 12.50㎍/L, respectively. This study revealed that high TBT concentration (≥ 3.20㎍/L) reduced growth and oxygen consumption rates of the juvenile oliver flounder suggesting potential influence on the natural mortality of Paralichthys olivaceus in the coastal areas.
ESPI 기법에 의한 하중을 받는 균열 박판의 진동 특성에 관한 연구
김경석,강기수,최지은,박찬주,홍진후 한국비파괴검사학회 2001 한국비파괴검사학회지 Vol.21 No.2
대부분의 실제구조물은 인장과 진동 등이 동시에 작용하는 복합하중 상태가 되며 이러한 환경에서 물체의 거동을 해석하는 것이 중요하다. 이 논문에서는 χ축에 대해 45˚결함이 있는 평판이 하중을 받고 있을 때, 진동 특성을 시간평균 electro speckle pattern interferometry(ESPI)를 이용하여 해석하였다. 결함이 있는 박판 시험편에 인장력을 증가하면서 물체의 고유진동수 변화와 모드의 형태 변화를 동시에 관찰하였다. 실험결과에서 결함은 저차모드에서는 진동모드에 영향을 주지 않았으나, 고차모드에서는 진동모드에 변화를 주었으며, 특정 진동모드에서 결함의 영향으로 현저하게 고유주파수가 낮아지는 경향을 보였다. 또한 실험결과는 유한요소해석과 비교하여 주파수 비교에서는 5%이내의 오차율을 보였으며, 진동모드 비교에서는 완전히 일치하였다. This paper presents the vibration characteristics of a rectangular plate with 45˚ oblique crack subjected to a uniaxial tension. The experiment is adopted by the time-average Electronic Speckle Pattern Interferometry(ESPI) method. The natural frequency and mode shape are considered accurately according to the increase of tensile load. When tensile load is zero, the vibration modes are agreed with the smooth and the 45˚ obliquely cracked plate. But according to the increasement of load, it is shown that vibration modes are extremely varied. The effects of the crack under the vibration are discussed in detail. It is indicated that the increase of load makes the variation of the frequencies and modes complicate in the range of even a small load. The results are agreed with the FEM analysis within 5%.
외인성 Estrogen에 노출된 조피볼락, Sebastes schiegeli 치어의 혈장 VTG과 GPT의 변화
황운기,강주찬 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.3
Changes of plasma vitellogenin (VTG) and glutamate pyruvate transaminase (GPT) were examined for determining whether hepatocyte was damaged during the process of VTG induction in the juvenile rockfish, Sebastes schlegeli exposed to exogenous estrogen (estradiol-17β, E₂). Rockfishes were intraperitoneally injected with E₂(5 mg/kg B.W.) in 70% ethanol and plasma sampling were extracted at 0, 1, 3, 6, 9, 12, l5 days after E₂ administration. VTG and GPT were then analyzed by SDS-PAGE and Reitman-Frankel method, respectively. VTG band was detected at a molecular weight position of 175 kDa on Day 3 after E₂ administration. This band became more distinct at 6 days, but its was gradually thinned with time-course, and not detected at 15 days. GPT was suddenly increased at 1 days after E₂ administration and highest GPT was detected at 3 days. However, OPT was gradually decreased with time-course as the change of VTG. These results suggest that the process of VTG induction by exogenous E₂ damage to hepatocyte, and plasma GPT was temporarily increased in the juvenile rockfish.
유기주석 노출에 의한 Mysid, Neomysis awatschensis의 독성 영향
지정훈,김상규,황운기,강주찬 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4
Tests for the toxicity of tributyltin (TBT) were conducted on mysid collected from Dadepo beach, Pusan, Korea. The toxic effects of tributyltin on the survival, growth and oxygen consumption of the mysid, Neomysis awatschensis have been evaluated. Mysids were exposed to several concentrations of TBT (0, 0.56, 1.15, 3.07 and 6.12 ㎍/L) for 6 weeks. Survival rate was decreased with increases in concentration and exposure time and the reduction of more than 40% occurred at TBT concentration greater than 1.15 ㎍/L after 6 weeks. Growth rate was significantly decreased at concentrations greater than 1.15 ㎍/L Oxygen consumption rate was also decreased in a concentration-dependent way and significantly decreased to 39, 47 and 69% of the control at 1. 15, 3.07 and 6.12 ㎍/L, respectively. These results indicate that the contamination of aquatic environment by TBT has the potential to significantly reduce coastal and estuaries recruitment of mysid.
의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics
박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.
Kang Min Ju,Kang Yun Jin,Park Chan-Soon 대한비과학회 2023 Journal of rhinology Vol.30 No.1
Positive airway pressure (PAP) therapy is known to be an effective treatment for obstructive sleep apnea (OSA) that does not generally have serious complications. However, pneumothorax following lung barotrauma with the use of PAP has rarely been reported. We recently experienced the case of a 72-year old male patient with chronic obstructive pulmonary disease who developed pneumothorax after the use of automatic PAP (APAP). After 4 months of APAP use with a pressure of 4–8 cm H2O, he complained of sudden severe dyspnea at midnight. He eventually underwent surgical repair for pneumothorax. After 4 months, continuous PAP with low pressure of 5 cm H2O was applied without any complications. In summary, we emphasize the risk of barotrauma when PAP is used by OSA patients with lung disease.