Characteristics of frequent emergency department users in Korea: a 4-year retrospective analysis using Korea Health Panel Study data

Jihoon Yoon,Min Joung Kim,김경환,박준석,신동운,김훈,전우찬,김현종,Jungeon Kim,박준민 대한응급의학회 2022 Clinical and Experimental Emergency Medicine Vol.9 No.2

Objective We aimed to investigate the characteristics of frequent emergency department (ED) users in Korea. Methods We analyzed the Korea Health Panel Study data of a sampled population from the 2005 Population Census of Korea data, and adults (age ≥18 years) who visited the ED at least once a year between 2014 and 2017 were included in the study. People who visited three or more times a year were classified as frequent users. We compared demographic, socioeconomic, and health-related factors between nonfrequent and frequent users. We used a multivariable logistic regression analysis to determine factors related to frequent ED visits. We also compared the characteristics of ED use in both nonfrequent and frequent users. Results A total of 5,090 panels were included, comprising 6,853 visits. Frequent users were 333 (6.5% of all panels), and their ED visits were 1,364 (19.9% of all ED visits). In the multivariable regression analysis, medical aid coverage (adjusted odds ratio [aOR] of the National Health Service coverage, 0.55; 95% confidence interval [CI], 0.40–0.75), unemployment (aOR of employment, 0.72; 95% CI, 0.56–0.91), prior ward admission in a year (aOR, 2.14; 95% CI, 1.67–2.75), and frequent outpatient department use (aOR, 1.72; 95% CI, 1.35–2.20) were associated with frequent use. Moreover, frequent users visited the ED of public hospitals more often than nonfrequent users (19.2% vs. 9.8%). Medical problems rather than injury/poisoning were the more common reasons for visiting the ED (84.5% vs. 71.2%). Conclusion We found that frequent ED users were likely to be those with socioeconomic disadvantage or with high demand for medical service. Based on this study, further studies on interventions to reduce frequent ED use are required for better ED services.

Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity

Yoon Jihoon G.,Jang Dong Geon,Cho Sung-Gyu,Lee Chaeyoung,Noh Shin Hye,Seo Soo Kyung,Yu Jung Woo,Chung Hyeon Woo,Han KyeoRe,Kwon Soon Sung,Han Dai Hoon,Oh Jaeseong,Jang In-Jin,Kim Sang-Hoon,Jee Young-K 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that may increase the susceptibility of individuals to AT-DILI and to examine genetic interactions that may lead to isoniazid (INH)-induced hepatotoxicity. We performed a targeted sequencing analysis of 380 pharmacogenes in a discovery cohort of 112 patients (35 AT-DILI patients and 77 controls) receiving AT treatment for active tuberculosis. Pharmacogenome-wide association analysis was also conducted using 1048 population controls (Korea1K). NAT2 and ATP7B genotypes were analyzed in a replication cohort of 165 patients (37 AT-DILI patients and 128 controls) to validate the effects of both risk genotypes. NAT2 ultraslow acetylators (UAs) were found to have a greater risk of AT-DILI than other genotypes (odds ratio [OR] 5.6 [95% confidence interval; 2.5–13.2], P = 7.2 × 10−6). The presence of ATP7B gene 832R/R homozygosity (rs1061472) was found to co-occur with NAT2 UA in AT-DILI patients (P = 0.017) and to amplify the risk in NAT2 UA (OR 32.5 [4.5–1423], P = 7.5 × 10−6). In vitro experiments using human liver-derived cell lines (HepG2 and SNU387 cells) revealed toxic synergism between INH and Cu, which were strongly augmented in cells with defective NAT2 and ATP7B activity, leading to increased mitochondrial reactive oxygen species generation, mitochondrial dysfunction, DNA damage, and apoptosis. These findings link the co-occurrence of ATP7B and NAT2 genotypes to the risk of INH-induced hepatotoxicity, providing novel mechanistic insight into individual AT-DILI susceptibility.

The First Korean Case of VEXAS Syndrome Caused by a UBA1 Somatic Variant

Yoon Jihoon G.,Lee Seungbok,Kim Sheehyun,Kim Man Jin,Chang Yoon Hwan,Park Jin Kyun,Shin Dong-Yeop,Moon Jangsup 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.2

자연신학 그리고/또는(and/or) 자연의 신학

윤지훈(Jihoon Yoon) 한신대학교 신학사상연구소 2023 신학사상 Vol.- No.201

본 논문은 자연신학(theologia naturalis)과 자연의 신학(theologia naturae)의 호혜성에 대한 연구의 가치와 필요성에 대해 논하는 것을 목적으로 한다. 신과 자연을 다루는 두 신학은 비슷해 보이지만 두 개념을 상반된 방법론으로 다룬다. 자연신학은 자연적으로 신을 인식하고 통찰하는 반면, 자연의 신학은 신학적으로 자연을 탐구한다. 한편으로 자연신학은 인간의 이성과 이를 기반으로 얻어진 자연 현상에 대한 법칙에 기초하여 신의 존재를 논증한다. 신 존재 증명을 위한 논증은 무신론에 대항한 기독교 변증학의 유용한 도구로 사용되어 왔다. 그러나 기독교 신학의 종말론적 의미에서 세계의 종말까지 신의 존재에 대한 논란의 여지가 사라지지 않는다는 신 존재 증명 자체에 대한 비판은 여전히 유효하기 때문에 자연신학적 무신론 논쟁에서 끝없는 소모전이 계속되고 있다. 다른 한편으로 자연의 신학은 반대로 신의 존재에 대한 믿음의 관점에서 자연과 자연 현상 및 법칙에 대한 보편적 이해를 찾는다. 이를 위해 다른 학문 분야로 분류되는 신학과 자연과학을 중재하는 매개체가 제시되는데, 그 필요성에 대한 논의는 매우 논쟁적이다. 이처럼 두 신학이 각기 다른 난관 속에서 한계에 직면하여 이를 타개할 혁신적인 방법과 방향을 필요로 하는 상황에서 두 신학의 호혜성은 그 방법과 방향이 될 수 있다. 두 신학은 상반된 도구와 대상을 바탕으로 논증하기 때문에 이들을 상호 협력 연구가 불가능한 절대적 상반 관계로 보기 쉽지만, 이들은 이미 암묵적으로 논증을 서로 차용하고 있다. 이것을 체계적으로 비교 분석하여 두 신학의 호혜성을 객관적으로 증명하고 이를 바탕으로 이들의 협력을 촉진하는 혁신적인 대안을 제시하는 것이 본 논문에서 논하는 연구의 관건이다. 본 논문은 이 연구의 가치와 필요성에 대해 논하기 위해 먼저 두 종류의 현대 자연신학 ― 윌리엄 레인 크레이그의 전통적인 자연신학과 알리스터 맥그래스의 새로운 자연신학 ― 과 볼프하르트 판넨베르크의 자연의 신학을 살펴보고, 다음으로 두 신학 사이의 상반 관계를 고찰한다. 이를 바탕으로 이 상반 관계를 과학신학의 당면한 상황으로서 두 신학의 호혜성을 그 당면한 과제로서 규정하고, 이들의 협력을 촉진하는 이들의 호혜성에 대한 비판적 비교 연구를 간략하게 제안한다. This article discusses the value and necessity of bringing the study of Natural Theology (theologia naturalis) and the Theology of Nature (theologia naturae) together. These two theological approaches, which both deal with God and nature, seem similar, but in fact treat the two concepts with opposing methodologies. For Natural Theology God is the focus of inquiry using natural reason, whereas for the Theology of Nature it is nature that is explained by means of God. On the one hand, Natural Theology argues for the existence of God based on human reason and the laws of natural phenomena based on reason. Arguments for the proof of God’s existence have been used as a useful tool in Christian apologetics against atheism. Natural-theological atheism , however, is a position that continues to be debated. This is because the criticism of the proof of God’s existence itself depends on Christian eschatology. In other words, the controversy over God’s existence cannot be settled before the end of the world and, therefore, objections to the notion of God’s existence on natural grounds are still valid. On the other hand, the Theology of Nature seeks a universal understanding of nature and natural phenomena and laws from the perspective of the belief in the existence of God. To this end, this paper presents a middle way between theology and natural science, which are classified as different academic disciplines. This is a controversial undertaking. Both Theologies face limitations and require innovative methods and directions to overcome them. Bringing the two Theologies more closely together may offer a helpful method and new direction. Since the two Theologies are based on opposite methods and objects, it is easy to view them as in an absolutely contradictory relationship in which it is impossible mutual cooperation research, but they have already implicitly borrowed arguments from each other. The key is to objectively prove the relationship of the two Theologies by systematically comparing and analyzing them, and, based on this, to present innovative alternatives that promote their cooperation. In order to discuss the value and necessity of this research, this article firstly looks into two types of modern Natural Theology – William Lane Craig’s traditional Natural Theology and Alister Edgar McGrath’s new Natural Theology. Next it inquires into Wolfhart Pannenberg’s Theology of Nature. It then examines the contradictory relationship between the two Theologies. Based on my findings, I show this contradiction to be the present dilemma of scientific theology and the raproachment of these two theological methodologies as its immediate task. I also briefly propose a critical comparative study of their reciprocity in promoting their cooperation.

기업환경에서 SSL 트래픽 검사 메커니즘에 관한 연구

윤지훈 ( Jihoon Yoon ),원유재 ( Yoojae Won ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.2

최근 기업 네트워크에서 암호화 트래픽 사용량이 증가하고 있으며, 악성 행위를 암호화하여 보안 장비를 우회하는 문제들이 발생하고 있다. 본 논문에서는 기업 네트워크 환경에서 암호화된 트래픽을 검사하기 위해 SSL 트래픽을 복호화하는 시스템을 제안한다. 제안하는 시스템은 암호화 트래픽 분석을 통해 악성 행위 및 기업 내부정보 유출 탐지에 활용할 수 있다.

스퍼터링을 이용한 바나듐 합금 박막화에 관한 연구

윤용호 ( Yongho Yoon ),정지훈 ( Jihoon Jung ) 한국화학공학회 2016 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.54 No.5

V-Cr-Y alloy is a material for hydrogen separation membrane possessing high transmittance and selectivity. In order to increase the rate of hydrogen permeation flux through the membrane, V-Cr-Y thin film was prepared using a sputtering technique and was investigated focusing on its basic properties. Thin film was deposited on a silicon wafer using a target including V (89.8%), Cr (10.0%) and Y(0.2%), and results of EDS analysis confirm that the ratio of metal in thin film agrees with that in the target. Higher sputtering temperature and power resulted in more rapid growth rate of the thin film and larger size of the crystals, and denser and finer crystal structure was observed when lower pressure was applied. An optimal sputtering condition was found with RF, 2mTorr, 300W and ambient temperature, and a suitable V-Cr-Y thin film for hydrogen separation was obtained upon heat treatment of the thin film prepared in this way.

One-Pot in Situ Fabrication of Stable Nanocaterpillars Directly from Polyacetylene Diblock Copolymers Synthesized by Mild Ring-Opening Metathesis Polymerization

Yoon, Ki-Young,Lee, In-Hwan,Kim, Kyung Oh,Jang, Jihoon,Lee, Eunji,Choi, Tae-Lim American Chemical Society 2012 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.134 No.35

<P>We report a direct one-pot route for the preparation of supramolecules from simple polyacetylene diblock copolymers synthesized by mild ring-opening metathesis polymerization of cyclooctatetraene. This in situ nanoparticlization of conjugated polymer (INCP) approach is advantageous over conventional self-assembly processes because this method does not require any tedious postsynthetic treatments. Also, this direct approach provides intriguing supramolecules with a unique nanostructure resembling a caterpillar. Furthermore, the new supramolecules are highly stable adducts because the polyacetylene core block provides an exceptionally strong driving force for the self-assembly. Even though pristine polyacetylene is unstable in air, the polyacetylene segment in the nanocaterpillar is very stable because it is protected within the shell of the supramolecule.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2012/jacsat.2012.134.issue-35/ja305150c/production/images/medium/ja-2012-05150c_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja305150c'>ACS Electronic Supporting Info</A></P>

Comparison of novel recombinant nucleoprotein ELISA with commercial ELISA for Newcastle disease

Jihoon Ryu,Hyeon Yoon,Ho-Jin Moon,Hyun-Jin Shin 한국예방수의학회 2021 예방수의학회지 Vol.45 No.1

In the present study, a novel ELISA method used recombinant nucleocapsid protein (rNP) as the coating agent. Recombinant Newcastle disease virus (NDV) protein was cloned and expressed in Escherichia coli. Though the rNP-ELISA results were consistent with commercial ELISA results for the NDV-negative sera samples, qualitatively and quantitatively variable (often reduced) results were obtained with NDV-positive sera. Although the rNP-ELISA results for NDV detection were inconclusive, further improvement and standardization of the rNP-ELISA approach, such as using multiple recombinant proteins as the ELISA coating agent and performing comprehensive statistical analyses of combined recombinant protein ELISA, should help counter Newcastle disease outbreaks by improving NDV detection.

A new risk-scoring model for predicting 30-day mortality after repair of abdominal aortic aneurysms in the era of endovascular procedures

Jihoon T Kim,Min-Ju Kim,Youngjin Han,Ji Yoon Choi,Gi-Young Ko,Tae-Won Kwon,Yong-Pil Cho 대한외과학회 2016 Annals of Surgical Treatment and Research(ASRT) Vol.90 No.2

Purpose: To propose a new, multivariable risk-scoring model for predicting 30-day mortality in individuals underwent repair of abdominal aortic aneurysms (AAA). Methods: Four hundred eighty-five consecutive patients who underwent AAA repair from January 2000 to December 2010 were included in the study. Univariate and multivariate analyses were performed to evaluate the risk factors, and a riskscoring model was developed. Results: Multivariate analysis identified three independent preoperative risk factors associated with mortality, and a risk-scoring model was created by assigning an equal value to each factor. The independent predictors were location of the AAA, rupture of AAA, and preoperative pulmonary dysfunction. The multivariable regression model demonstrated moderate discrimination (c statistic, 0.811) and calibration (Hosmer-Lemeshow test, P = 0.793). The observed mortality rate did not differ significantly from that predicted by our risk-scoring model. Conclusion: Our risk-scoring model has excellent ability to predict 30-day mortality after AAA repair, and awaits validation in further studies.

Origin of Green Emission in Extremely Pure Oligofluorene Films

Jihoon Kang,Nayool Shin,Jungho Jo,Panagiotis E. Keivanidis,Frederic Laquai,Gerhard Wegner,Do Y. Yoon 한국고분자학회 2006 한국고분자학회 학술대회 연구논문 초록집 Vol.2006 No.10