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Antioxidant Responsiveness in BALB/c Mice Exposed to Ozone
Jang, An-Soo,Choi, Inseon-S.,Yang, Sung-Yeul,Kim, Young-Gon,Lee, June-Hyuk,Park, Sung-Woo,Park, Choon-Sik S. Karger AG 2005 Respiration Vol.72 No.1
<P><I>Background:</I> A single, acute exposure to ozone has been shown to modify the antioxidant defense mechanism in the respiratory tract. <I>Objective:</I> The aim of this study was to evaluate the effects of ozone exposure on antioxidant response in BALB/c mice. <I>Methods:</I> We measured enhanced pause of breathing (Penh) as a marker of airway obstruction using barometric whole-body plethysmography before and after ozone exposure [groups (n = 6): filtered air, 0.12 ppm, 0.5 ppm, 1 ppm, 2 ppm] for 3 h. Antioxidant levels were measured using high-performance liquid chromatography with electrochemical detection in bronchoalveolar lavage (BAL) fluid and lung tissue homogenates. <I>Results:</I> Malondialdehyde concentrations in lung tissue homogenates were significantly increased in the group exposed to 2-ppm ozone compared to the filtered air group. Uric acid and γ-tocopherol concentrations in BAL fluid were significantly increased in the ozone exposure group compared to the filtered air group (p < 0.01). Uric acid concentrations were increased in a concentration-dependent manner according to ozone concentration to which the animals were exposed. Increases in Penh after ozone exposure were significantly higher in an ozone concentration-dependent manner. The proportion of neutrophils in BAL fluid was significantly higher in the group exposed to 2 ppm than in the filtered air and the group exposed to 0.12 ppm (p < 0.01, respectively). The level of ascorbate correlated with the level of γ-tocopherol. <I>Conclusion:</I> These findings suggest that antioxidant responses may serve as a protective mechanism against a range of oxidants in BALB/c mice exposed to ozone. </P><P>Copyright © 2005 S. Karger AG, Basel</P>
( Inseon S Choi ),( Da Woon Sim ),( Seung Hoon Kim ),( Jin Woo Wi ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: We reported previously that as much as 1/3 of hospitalized asthmatics treated with inhaled steroids (ICS) for average 4.5 years showed adrenal insuffi ciency in a dose-dependent manner. Because the result might be overestimated due to subject selection bias, this study examined adrenal function in out-patient asthmatics of a tertiary hospital. Methods: Twelve normal control and 135 consecutive adult asthmatics under ICS treatment for 6 months or more underwent a rapid ACTH stimulation test. Adrenal insuffi ciency was defi ned as a serum morning cortisol level < 3 ㎍/dL or failure in rising of the level to >18 ㎍/dL after an administration of 250 ㎍ ACTH. Results: The mean duration of ICS use in the patients were 8.30±0.43 years. Adrenal insuffi ciency was found in a manner dependent on the ICS daily doses [control 2/12 (16.7%), low 17/29 (58.6%), medium 34/54 (63.0%), and high 32/52 (61.5%); X²=4.23, P=0.04]. The total doses of nasal steroid (NCS) and ICS were signifi cantly related with each other (r=0.543, P=0.000). The number of NCS canisters (32.5±2.7 vs. 24.8±2.6, P=0.04), but not the duration/total dose of ICS, was signifi cantly higher in the patients with adrenal insuffi ciency than the other patients. Only the NCS dose seemed to relate with adrenal insuffi ciency [odds ratio: 1.016 (95% CI: 1.000-1.033); P=0.056]. Conclusion: Even low dose ICS seem to induce adrenal insuffi ciency in more than a half of asthmatics when it was administered for a very long time, especially in the patients used NCS together.
( Inseon S. Choi ),( Seo Na Hong ),( Yeon Kyung Lee ),( Youngil I. Koh ),( An Soo Jang ),( Hyeon Cheol Lee ) 대한내과학회 2003 The Korean Journal of Internal Medicine Vol.18 No.2
Background: Airway hyperresponsiveness (AHR) to direct stimuli, such as methacholine (MCh), is observed not only in asthma but other diseases. AHR to indirect stimuli is suggested to be more specific for asthma. The purpose of this study was to determine